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公开(公告)号：US20140336190A1
公开(公告)日：2014-11-13
申请号：US14273147
申请日：2014-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D471/04 , C07D413/14 , C07D417/14 , C07D413/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 本申请涉及可用作抑制剂的化合物; 或其它可能调节含溴结构域的蛋白质（包括含有溴结构域的蛋白质4（BRD4））的活性，以及含有这些化合物的组合物和制剂，以及使用和制备这些化合物的方法。 化合物包括其中R1a，R1b，R2，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
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公开(公告)号：US11124487B2
公开(公告)日：2021-09-21
申请号：US16441339
申请日：2019-06-14
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory Chin , Richard L. Mackman , Michael R. Mish , Jeff Zablocki
IPC: C07D239/95 , C07D487/04 , C07D471/04 , C07D495/04 , A61K31/517 , A61K31/519 , A61P35/00 , A61P31/18 , A61K45/06
Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
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公开(公告)号：US20200017451A1
公开(公告)日：2020-01-16
申请号：US16441339
申请日：2019-06-14
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory Chin , Richard L. Mackman , Michael R. Mish , Jeff Zablocki
IPC: C07D239/95 , C07D495/04 , C07D487/04 , C07D471/04 , A61K45/06 , A61K31/519 , A61K31/517 , A61P35/00 , A61P31/18
Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
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公开(公告)号：US20180282316A1
公开(公告)日：2018-10-04
申请号：US16001832
申请日：2018-06-06
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna M. Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Andrew Lee , Ruben Martinez , Samuel E. Metobo , Michael R. Mish , Manuel Munoz , Sophia L. Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/04 , C07D453/02 , C07D417/14 , C07D471/04 , C07D413/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
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公开(公告)号：US09458145B2
公开(公告)日：2016-10-04
申请号：US14273147
申请日：2014-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D471/04 , C07D417/14 , C07D413/14 , C07D413/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 本申请涉及可用作抑制剂的化合物; 或其它可能调节含溴结构域的蛋白质（包括含有溴结构域的蛋白质4（BRD4））的活性，以及含有这些化合物的组合物和制剂，以及使用和制备这些化合物的方法。 化合物包括其中R1a，R1b，R2，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
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Patent Agency Ranking
公开(公告)号：US09255089B2
公开(公告)日：2016-02-09
申请号：US14227736
申请日：2014-03-27
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael R. Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/14 , C07D413/04 , C07D417/14
CPC classification number: C07D413/14 , C07D413/04 , C07D417/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3和X在本文中描述的式（I）的化合物。
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公开(公告)号：US20240254091A1
公开(公告)日：2024-08-01
申请号：US18476141
申请日：2023-09-27
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory Chin , Richard L. Mackman , Michael R. Mish , Jeff Zablocki
IPC: C07D239/95 , A61K31/517 , A61K31/519 , A61K45/06 , A61P31/18 , A61P35/00 , C07D471/04 , C07D487/04 , C07D495/04
CPC classification number: C07D239/95 , A61K31/517 , A61K31/519 , A61K45/06 , A61P31/18 , A61P35/00 , C07D471/04 , C07D487/04 , C07D495/04
Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
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公开(公告)号：US20220241281A1
公开(公告)日：2022-08-04
申请号：US17496962
申请日：2021-10-08
Applicant: Gilead Sciences, Inc.
Inventor： Gregory Chin , Michael O`Neil Hanrahan Clarke , Xiaochun Han , Tim Hansen , Yunfeng Eric Hu , Dmitry Koltun , Ryan McFadden , Michael R. Mish , Eric Q. Parkhill , David Sperandio , Lianhong Xu , Hai Yang
IPC: A61K31/519 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D519/00
Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.
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公开(公告)号：US20220218709A1
公开(公告)日：2022-07-14
申请号：US17540563
申请日：2021-12-02
Applicant: GILEAD SCIENCES, INC.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Richard L. Mackman , Samuel E. Metobo , Michael R. Mish , Hyung-Jung Pyun , Jeff Zablocki
IPC: A61K31/517 , C07D471/04 , C07D239/84 , C07D401/04
Abstract: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.
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公开(公告)号：US11179397B2
公开(公告)日：2021-11-23
申请号：US16591092
申请日：2019-10-02
Applicant: Gilead Sciences, Inc.
Inventor： Gregory Chin , Michael O' Neil Hanrahan Clarke , Xiaochun Han , Tim Hansen , Yunfeng Eric Hu , Dmitry Koltun , Ryan McFadden , Michael R. Mish , Eric Q. Parkhill , David Sperandio , Lianhong Xu , Hai Yang
IPC: C07D487/04 , A61K31/519 , A61K45/06 , C07D471/04 , C07D471/10 , C07D519/00
Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.
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