公开(公告)号：US12264173B2

公开(公告)日：2025-04-01

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: A61P31/14 ,  A61K31/661 ,  A61K31/675 ,  A61P31/12 ,  C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20240417411A1

公开(公告)日：2024-12-19

申请号：US18645671

申请日：2024-04-25

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Jennifer L. Cosman Ellis ,  Yifan Deng ,  Richard L. Mackman ,  Xianhuang Zeng

IPC: C07D519/00 ,  A61K31/53 ,  A61K45/06

Abstract: The present disclosure provides compounds of Formula I: Also provided are pharmaceutical compositions comprising the compounds of Formula I, as well as uses thereof.

公开(公告)号：US12030903B2

公开(公告)日：2024-07-09

申请号：US17178115

申请日：2021-02-17

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Michael O. Clarke ,  Bindu Goyal ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel

IPC: C07F9/6561 ,  A61K45/06

CPC classification number: C07F9/6561 ,  A61K45/06

Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.

公开(公告)号：US20230125751A1

公开(公告)日：2023-04-27

申请号：US17854818

申请日：2022-06-30

Applicant: Gilead Sciences, Inc.

Inventor： Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dorothy Agnes Theodore

IPC: C07D487/04 ,  C07H19/04 ,  A61K9/00 ,  A61K31/706 ,  A61K45/06 ,  C07H7/06 ,  C07F9/6561

Abstract: Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.

公开(公告)号：US11304948B2

公开(公告)日：2022-04-19

申请号：US16718311

申请日：2019-12-18

Applicant: Gilead Sciences, Inc. ,  Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.

Inventor： Ondrej Baszczynski ,  Milan Dejmek ,  Yunfeng Eric Hu ,  Petr Jansa ,  Eric Lansdon ,  Richard L. Mackman ,  Petr Simon

IPC: C07D403/12 ,  A61K31/517 ,  C07D401/12 ,  C07D239/94 ,  A61P31/18 ,  A61K45/06 ,  C07D239/84 ,  C07D239/95

Abstract: Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.

公开(公告)号：US20220081462A1

公开(公告)日：2022-03-17

申请号：US17458023

申请日：2021-08-26

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Hon C. Hui ,  Rao V. Kalla ,  Richard L. Mackman

IPC: C07H7/06 ,  A61P31/12

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20210017170A1

公开(公告)日：2021-01-21

申请号：US16911643

申请日：2020-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Andrea Ambrosi ,  Sylvie M. Asselin ,  Florence J. Bachrach ,  Pavel R. Badalov ,  Gregory F. Chin ,  Stephen P. Lathrop ,  Willard Lew ,  Richard L. Mackman ,  Jeffrey E. Merit ,  Samuel E. Metobo ,  Michael R. Mish ,  Beau P. Pritchett ,  Hyung-Jung Pyun ,  Christopher S. Regens ,  Tiago Vieira ,  Xianghong Wang ,  Adam B. Weinstein ,  Todd A. Wenderski ,  Zehua Zheng

IPC: C07D471/04 ,  C07D213/81 ,  C07D413/04

Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.

公开(公告)号：US10695357B2

公开(公告)日：2020-06-30

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20200157137A1

公开(公告)日：2020-05-21

申请号：US16454536

申请日：2019-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/073 ,  A61K31/7068 ,  A61K31/7072

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US10370342B2

公开(公告)日：2019-08-06

申请号：US15692093

申请日：2017-08-31

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Richard L. Mackman ,  Michael R. Mish ,  Jeff Zablocki

IPC: C07D239/95 ,  A61K31/517 ,  A61P31/18 ,  A61P35/00 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.