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公开(公告)号：US12030903B2
公开(公告)日：2024-07-09
申请号：US17178115
申请日：2021-02-17
发明人： Daniel H. Byun , Gregory F. Chin , Michael O. Clarke , Bindu Goyal , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel
IPC分类号： C07F9/6561 , A61K45/06
CPC分类号： C07F9/6561 , A61K45/06
摘要： The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.
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公开(公告)号：US20230125751A1
公开(公告)日：2023-04-27
申请号：US17854818
申请日：2022-06-30
IPC分类号： C07D487/04 , C07H19/04 , A61K9/00 , A61K31/706 , A61K45/06 , C07H7/06 , C07F9/6561
摘要： Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
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公开(公告)号：US11304948B2
公开(公告)日：2022-04-19
申请号：US16718311
申请日：2019-12-18
发明人： Ondrej Baszczynski , Milan Dejmek , Yunfeng Eric Hu , Petr Jansa , Eric Lansdon , Richard L. Mackman , Petr Simon
IPC分类号： C07D403/12 , A61K31/517 , C07D401/12 , C07D239/94 , A61P31/18 , A61K45/06 , C07D239/84 , C07D239/95
摘要： Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
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公开(公告)号：US20220081462A1
公开(公告)日：2022-03-17
申请号：US17458023
申请日：2021-08-26
发明人： Byoung-Kwon Chun , Hon C. Hui , Rao V. Kalla , Richard L. Mackman
摘要： Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.
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公开(公告)号：US20210017170A1
公开(公告)日：2021-01-21
申请号：US16911643
申请日：2020-06-25
发明人： Evangelos Aktoudianakis , Andrea Ambrosi , Sylvie M. Asselin , Florence J. Bachrach , Pavel R. Badalov , Gregory F. Chin , Stephen P. Lathrop , Willard Lew , Richard L. Mackman , Jeffrey E. Merit , Samuel E. Metobo , Michael R. Mish , Beau P. Pritchett , Hyung-Jung Pyun , Christopher S. Regens , Tiago Vieira , Xianghong Wang , Adam B. Weinstein , Todd A. Wenderski , Zehua Zheng
IPC分类号： C07D471/04 , C07D213/81 , C07D413/04
摘要： The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.
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公开(公告)号：US10695357B2
公开(公告)日：2020-06-30
申请号：US16274049
申请日：2019-02-12
发明人： Byoung Kwon Chun , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056 , A61K31/685 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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公开(公告)号：US20200157137A1
公开(公告)日：2020-05-21
申请号：US16454536
申请日：2019-06-27
IPC分类号： C07H19/06 , C07H19/10 , C07H19/073 , A61K31/7068 , A61K31/7072
摘要： Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.
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公开(公告)号：US10370342B2
公开(公告)日：2019-08-06
申请号：US15692093
申请日：2017-08-31
IPC分类号： C07D239/95 , A61K31/517 , A61P31/18 , A61P35/00 , A61K31/519 , A61K45/06 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
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公开(公告)号：US10251898B2
公开(公告)日：2019-04-09
申请号：US15902690
申请日：2018-02-22
发明人： Byoung Kwon Chun , Michael O'Neil Hanrahan Clarke , Edward Doerffler , Hon Chung Hui , Robert Jordan , Richard L. Mackman , Jay P. Parrish , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056 , A61K31/685 , C07D487/04 , C07D519/00 , C07F9/24 , C07F9/6561 , A61K31/675 , A61K45/06 , A61K31/00 , A61K31/53 , C07H1/00 , C07H1/02 , C07H11/00 , C07H15/18 , A61K31/6615 , A61K31/665 , A61K31/683
摘要： Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
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![Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections](/abs-image/US/2019/01/15/US10179794B2/abs.jpg.150x150.jpg)
公开(公告)号：US10179794B2
公开(公告)日：2019-01-15
申请号：US15717493
申请日：2017-09-27
IPC分类号： C07H7/06 , C07H11/04 , C07D495/04
摘要： Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.
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