公开(公告)号：US20230295201A1

公开(公告)日：2023-09-21

申请号：US18171950

申请日：2023-02-21

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561 ,  A61K31/706

CPC classification number: C07F9/6561 ,  A61K31/706

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US11548901B2

公开(公告)日：2023-01-10

申请号：US16868119

申请日：2020-05-06

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D487/14 ,  C07D498/14 ,  A61K31/537 ,  C07D471/22 ,  A61K31/529 ,  A61K31/551 ,  A61K31/498 ,  C07D471/18 ,  A61K45/06 ,  C07D498/18 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20190092787A1

公开(公告)日：2019-03-28

申请号：US16017371

申请日：2018-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: C07D498/14 ,  A61K45/06 ,  C07D498/18 ,  A61K31/498 ,  A61K31/551 ,  A61K31/537 ,  C07D471/18 ,  C07D471/22 ,  A61K31/4985 ,  A61K31/529 ,  C07D487/14 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20240043427A1

公开(公告)日：2024-02-08

申请号：US17997594

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07K16/2827 ,  C07K16/2818 ,  A61K45/06

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US11124487B2

公开(公告)日：2021-09-21

申请号：US16441339

申请日：2019-06-14

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory Chin ,  Richard L. Mackman ,  Michael R. Mish ,  Jeff Zablocki

IPC: C07D239/95 ,  C07D487/04 ,  C07D471/04 ,  C07D495/04 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  A61P31/18 ,  A61K45/06

Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.

公开(公告)号：US10689399B2

公开(公告)日：2020-06-23

申请号：US16017371

申请日：2018-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Zhenhong R. Cai ,  Xiaowu Chen ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Mingzhe Ji ,  Haolun Jin ,  Scott E. Lazerwith ,  Michael R. Mish ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  James G. Taylor ,  Teresa Alejandra Trejo Martin

IPC: A61K31/4985 ,  C07D413/14 ,  C07D498/14 ,  A61K31/537 ,  C07D471/22 ,  A61K31/529 ,  A61K31/551 ,  A61K31/498 ,  C07D471/18 ,  A61K45/06 ,  C07D498/18 ,  C07D487/14 ,  A61K31/553

Abstract: Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US20200017451A1

公开(公告)日：2020-01-16

申请号：US16441339

申请日：2019-06-14

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory Chin ,  Richard L. Mackman ,  Michael R. Mish ,  Jeff Zablocki

IPC: C07D239/95 ,  C07D495/04 ,  C07D487/04 ,  C07D471/04 ,  A61K45/06 ,  A61K31/519 ,  A61K31/517 ,  A61P35/00 ,  A61P31/18

Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.

公开(公告)号：US20180282316A1

公开(公告)日：2018-10-04

申请号：US16001832

申请日：2018-06-06

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna M. Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Rick Andrew Lee ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael R. Mish ,  Manuel Munoz ,  Sophia L. Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/04 ,  C07D453/02 ,  C07D417/14 ,  C07D471/04 ,  C07D413/14

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

公开(公告)号：US09255089B2

公开(公告)日：2016-02-09

申请号：US14227736

申请日：2014-03-27

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael R. Mish ,  Sophie Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/14 ,  C07D413/04 ,  C07D417/14

CPC classification number: C07D413/14 ,  C07D413/04 ,  C07D417/14

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.

Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3和X在本文中描述的式（I）的化合物。

公开(公告)号：US12091420B2

公开(公告)日：2024-09-17

申请号：US18376159

申请日：2023-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Jessica L. Mckinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  C07D401/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  C07D401/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.