公开(公告)号：US20230357370A1

公开(公告)日：2023-11-09

申请号：US18323185

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230348575A1

公开(公告)日：2023-11-02

申请号：US18323209

申请日：2023-05-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20230348574A1

公开(公告)日：2023-11-02

申请号：US18173006

申请日：2023-02-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

CPC classification number: C07K16/1027 ,  A61K39/12 ,  A61K39/155 ,  C07K14/005 ,  A61K2039/5252

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20220340645A1

公开(公告)日：2022-10-27

申请号：US17848205

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.

公开(公告)号：US20220332767A1

公开(公告)日：2022-10-20

申请号：US17848247

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20220332766A1

公开(公告)日：2022-10-20

申请号：US17848230

申请日：2022-06-23

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Andrea CARFI

IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155

Abstract: The invention relates to pre-fusion RSV F protein and polypeptides that contain one or more amino acid mutations that stabilize the pre-fusion conformation or destabilize the post-fusion conformation. The invention also relates to methods for inducing an immune response to pre-fusion RSV F.

公开(公告)号：US20220213177A1

公开(公告)日：2022-07-07

申请号：US17564962

申请日：2021-12-29

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Kurt SWANSON ,  Philip R. DORMITZER

IPC: C07K16/10 ,  A61K39/155 ,  A61K39/12 ,  C07K14/005

Abstract: The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.