公开(公告)号：US20190054296A1

公开(公告)日：2019-02-21

申请号：US16080203

申请日：2017-02-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Alessandra GIAROLA ,  Yee-Hsee HSIEH ,  Stephen J. LEWIS ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61B5/08 ,  A61B5/00 ,  A61N1/05

Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US20210069504A1

公开(公告)日：2021-03-11

申请号：US16771441

申请日：2018-12-11

Applicant: Galvani Bioelectronics Limited

Inventor： Gerald Edwin HUNSBERGER ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.

公开(公告)号：US20200179699A1

公开(公告)日：2020-06-11

申请号：US16320288

申请日：2017-07-25

Applicant: Galvani Bioelectronics Limited ,  Case Western Reserve University

Inventor： Arun SRIDHAR ,  Corey SMITH ,  Kyle WOLF ,  Georgy ZARKUA ,  Shyue-An CHAN

IPC: A61N1/36 ,  A61N1/05

Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.

公开(公告)号：US20190184172A1

公开(公告)日：2019-06-20

申请号：US16328090

申请日：2017-08-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  GALVANI BIOELECTRONICS LIMITED

Inventor： Jeffrey Laurence ARDELL ,  Kalyanam SHIVKUMAR ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/05 ,  A61N1/362

CPC classification number: A61N1/36114 ,  A61N1/0556 ,  A61N1/36057 ,  A61N1/362

Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.

公开(公告)号：US20180214691A1

公开(公告)日：2018-08-02

申请号：US15749063

申请日：2016-08-03

Applicant: GALVANI BIOELECTRONICS LIMITED ,  DUKE UNIVERSITY

Inventor： Hans Jakob Kristoffer FAMM ,  Warren Murray GRILL ,  James Arthur HOKANSON ,  Christopher Lawrence LANGDALE ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61N1/372 ,  A61P13/10

Abstract: The present invention provides improved devices, systems and methods to provide for control of bladder function. Aspects of the present disclosure relate to an apparatus, system and/or a method for modulating the neural activity of afferent fibres of the pelvic nerve to bladder function. In one aspect, the disclosure relates to the use of pharmaceutical compositions in patients undergoing neuromodulation therapy.