公开(公告)号：US20160264567A1

公开(公告)日：2016-09-15

申请号：US15042310

申请日：2016-02-12

Applicant: Genentech, Inc.

Inventor： Po-wai YUEN ,  Anthony ESTRADA ,  Huifen CHEN ,  Aleksandr KOLESNIKOV ,  Elisia VILLEMURE ,  Vishal VERMA ,  Lan WANG ,  Daniel SHORE ,  Steven DO ,  Matthew VOLGRAF ,  Baihua HU ,  Guosheng WU ,  Xingyu LIN ,  Aijun LU

IPC: C07D417/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07F9/6512 ,  C07D417/12 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07F9/6512

Abstract: The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

Abstract translation: 和其盐和本文公开的其它式II-IX化合物。 此外，本发明涉及制造方法和使用式I-IX化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛或哮喘。

公开(公告)号：US20250122184A1

公开(公告)日：2025-04-17

申请号：US18985661

申请日：2024-12-18

Applicant: Genentech, Inc.

Inventor： Jack Alexander TERRETT ,  Huifen CHEN ,  Lea CONSTANTINEAU-FORGET ,  Robin Larouche-Gauthier ,  Luce LÉPISSIER ,  Francis BEAUMIER ,  Martin DÉRY ,  Chantal GRAND-MAÎTRE ,  Claudio STURINO ,  Matthew VOLGRAF ,  Elisia VILLEMURE

IPC: C07D413/14 ,  A61K31/427 ,  A61P11/00 ,  A61P23/00 ,  A61P25/00 ,  A61P29/00 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof wherein A, X, R1, R4 and n are as defined herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20220348559A1

公开(公告)日：2022-11-03

申请号：US17198238

申请日：2021-03-10

Applicant: Genentech, Inc.

Inventor： Snahel PATEL ,  Gregory HAMILTON ,  Craig STIVALA ,  Huifen CHEN ,  Guiling ZHAO

IPC: C07D403/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D495/04 ,  C07D491/04 ,  C07D491/10 ,  C07D413/14 ,  C07D491/044 ,  C07D491/048 ,  C07D491/052 ,  C07D519/00

Abstract: The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds.

公开(公告)号：US20190284189A1

公开(公告)日：2019-09-19

申请号：US16421114

申请日：2019-05-23

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Daniel SHORE ,  Elisia VILLEMURE ,  Matthew VOLGRAF ,  Baihua HU ,  Aijun LU ,  Andrew CRIDLAND ,  Stuart WARD ,  Francis BEAUMIER ,  Martin DERY ,  Robin LAROUCHE-GAUTHIER

IPC: C07D473/30 ,  C07D471/04 ,  C07D513/04 ,  C07D487/04

Abstract: The invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.

公开(公告)号：US20180282272A1

公开(公告)日：2018-10-04

申请号：US16001770

申请日：2018-06-06

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Yanyan CHU ,  Steven DO ,  Anthony ESTRADA ,  Baihua HU ,  Aleksandr KOLESNIKOV ,  Xingyu LIN ,  Joseph P. LYSSIKATOS ,  Daniel SHORE ,  Vishal VERMA ,  Lan WANG ,  Guosheng WU ,  Po-wai YUEN

IPC: C07D207/48 ,  C07D451/02 ,  C07D491/048 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20160221945A1

公开(公告)日：2016-08-04

申请号：US15095467

申请日：2016-04-11

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Yanyan CHU ,  Steven DO ,  Anthony ESTRADA ,  Baihua HU ,  Aleksandr KOLESNIKOV ,  Xingyu LIN ,  Joseph P. LYSSIKATOS ,  Daniel SHORE ,  Vishal VERMA ,  Lan WANG ,  Guosheng WU ,  Po-wai YUEN

IPC: C07D207/48 ,  C07D403/12 ,  C07D403/14 ,  C07D417/12 ,  C07D405/14 ,  C07D491/048 ,  C07D451/02 ,  C07D401/14 ,  C07D401/12

Abstract: The invention is concerned with the compounds of formula I or II: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I or II as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract translation: 本发明涉及式I或II化合物及其盐。 此外，本发明涉及制备方法和使用式I或II化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗TRPA1介导的疾病和病症，例如疼痛。

公开(公告)号：US20150197509A1

公开(公告)日：2015-07-16

申请号：US14671643

申请日：2015-03-27

Applicant: Hoffmann-La Roche Inc. ,  GENENTECH, INC.

Inventor： Christine E. BROTHERTON-PLEISS ,  Huifen CHEN ,  Shaoqing CHEN ,  Zhi CHEN ,  Shawn David ERICKSON ,  Anthony ESTRADA ,  Kyungjin KIM ,  Hongju LI ,  Allen John LOVEY ,  Joseph P. LYSSIKATOS ,  Yimin QIAN ,  Sung-Sau SO ,  Peter Michael WOVKULICH ,  Lin YI, I

IPC: C07D409/12 ,  C07C311/17 ,  C07D239/26 ,  C07C311/20 ,  C07D403/12 ,  C07D305/06 ,  C07D401/04 ,  C07D401/12 ,  C07D305/08 ,  C07D237/08 ,  C07C311/16 ,  C07D213/40

CPC classification number: C07D409/12 ,  C07C311/16 ,  C07C311/17 ,  C07C311/19 ,  C07C311/20 ,  C07C2601/02 ,  C07D213/26 ,  C07D213/40 ,  C07D231/18 ,  C07D237/08 ,  C07D239/26 ,  C07D239/42 ,  C07D241/12 ,  C07D305/06 ,  C07D305/08 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D409/14

Abstract: The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R1, R2, R3, R3′, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

Abstract translation: 本发明涉及式（I）化合物及其盐，其中X，Y，Z，R 1，R 2，R 3，R 3，R 4，R 5和R 6在详细说明书和权利要求书中定义。 此外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗TRPA1介导的疾病和病症，例如疼痛。