公开(公告)号：US20240398781A1

公开(公告)日：2024-12-05

申请号：US18670608

申请日：2024-05-21

Applicant: GENENTECH, INC. ,  CONVELO THERAPEUTICS, INC.

Inventor： Marie-Gabrielle BRAUN ,  Georgette CASTANEDO ,  William VERNIER ,  Matthew VOLGRAF ,  James Guy BREITENBUCHER ,  Brad LANG

IPC: A61K31/4545 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/454 ,  C07D495/10

Abstract: The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

公开(公告)号：US20210261568A1

公开(公告)日：2021-08-26

申请号：US17150380

申请日：2021-01-15

Applicant: Genentech, Inc.

Inventor： Jeffrey A. STAFFORD ,  James M. VEAL ,  Lynnie Lin TRZOSS ,  Christopher MCBRIDE ,  Richard M. PASTOR ,  Steven Thomas STABEN ,  Craig STIVALA ,  Matthew VOLGRAF

IPC: C07D498/04

Abstract: The present disclosure relates to novel sulfonylurea compounds and related compounds useful in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

公开(公告)号：US20200002340A1

公开(公告)日：2020-01-02

申请号：US16558718

申请日：2019-09-03

Applicant: Genentech, Inc.

Inventor： Huifen CHEN ,  Brian SAFINA ,  Daniel SHORE ,  Jack TERRETT ,  Elisia VILLEMURE ,  Matthew VOLGRAF ,  Stuart WARD ,  Aijun LU ,  Robin LAROUCHE-GAUTHIER ,  Francis BEAUMIER ,  Martin DERY ,  Lea CONSTANTINEAU-FORGET ,  Chantal GRAND-MAITRE ,  Luce LEPISSIER

IPC: C07D473/30 ,  C07D471/04 ,  C07D487/04 ,  C07D473/08

Abstract: The invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20190144428A1

公开(公告)日：2019-05-16

申请号：US16250230

申请日：2019-01-17

Applicant: Genentech, Inc.

Inventor： Vishal VERMA ,  Daniel SHORE ,  Matthew VOLGRAF ,  Anthony A. ESTRADA ,  Joseph LYSSIKATOS

IPC: C07D401/14 ,  C07D403/14 ,  C07D403/12 ,  C07D405/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: The invention is concerned with the compounds of formula I: and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

公开(公告)号：US20160264567A1

公开(公告)日：2016-09-15

申请号：US15042310

申请日：2016-02-12

Applicant: Genentech, Inc.

Inventor： Po-wai YUEN ,  Anthony ESTRADA ,  Huifen CHEN ,  Aleksandr KOLESNIKOV ,  Elisia VILLEMURE ,  Vishal VERMA ,  Lan WANG ,  Daniel SHORE ,  Steven DO ,  Matthew VOLGRAF ,  Baihua HU ,  Guosheng WU ,  Xingyu LIN ,  Aijun LU

IPC: C07D417/14 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07F9/6512 ,  C07D417/12 ,  C07D405/14 ,  C07D401/14 ,  C07D401/12

CPC classification number: C07D417/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07F9/6512

Abstract: The invention is concerned with the compounds of formula I: and salts thereof and other compounds of formulas II-IX as disclosed herein. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formulas I-IX as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain or asthma.

Abstract translation: 和其盐和本文公开的其它式II-IX化合物。 此外，本发明涉及制造方法和使用式I-IX化合物的方法以及含有这些化合物的药物组合物。 该化合物可用于治疗由TRPA1介导的疾病和病症，例如疼痛或哮喘。