公开(公告)号：US20140303355A1

公开(公告)日：2014-10-09

申请号：US14282063

申请日：2014-05-20

Applicant: Genentech, Inc.

Inventor： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

IPC: C07K16/40

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract translation: 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。

公开(公告)号：US20140093889A1

公开(公告)日：2014-04-03

申请号：US13972443

申请日：2013-08-21

Applicant: Genentech, Inc.

Inventor： Kang Li ,  Bin-Bing Stephen Zhou ,  Wenjuan Wu ,  Sek Chung Fung ,  Sanjaya Singh

IPC: C07K16/30 ,  G01N33/574

CPC classification number: C07K16/30 ,  A61K39/00 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  C07K16/00 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/75 ,  C07K2319/30 ,  G01N33/57492 ,  G01N33/6893

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract translation: 本发明涉及特异性结合Notch 3并激活信号传导的激动剂抗体。 本发明包括与包含第一Lin12结构域的表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。

公开(公告)号：US09518124B2

公开(公告)日：2016-12-13

申请号：US13972443

申请日：2013-08-21

Applicant: Genentech, Inc.

Inventor： Kang Li ,  Bin-Bing Stephen Zhou ,  Wenjuan Wu ,  Sek Chung Fung ,  Sanjaya Singh

IPC: A61K39/00 ,  C07K16/30 ,  C07K16/00 ,  C07K16/28 ,  G01N33/68 ,  G01N33/574 ,  A61K39/395

CPC classification number: C07K16/30 ,  A61K39/00 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  C07K16/00 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/75 ,  C07K2319/30 ,  G01N33/57492 ,  G01N33/6893

Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract translation: 本发明涉及特异性结合Notch 3并激活信号传导的激动剂抗体。 本发明包括与包含第一Lin12结构域的表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。

公开(公告)号：US20130171070A1

公开(公告)日：2013-07-04

申请号：US13759613

申请日：2013-02-05

Applicant: Genentech, Inc.

Inventor： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry b. Lowman ,  Sanjaya Singh ,  Herren Wu

IPC: C07K16/40

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

公开(公告)号：US20130144040A1

公开(公告)日：2013-06-06

申请号：US13669230

申请日：2012-11-05

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Kang Li ,  Yucheng Li ,  Sanjaya Singh ,  Bin-Bing Stephen Zhou

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

Abstract translation: 本发明涉及特异性结合Notch 3并抑制其活化的拮抗剂抗体。 本发明包括与包含第一Lin12结构域和第二二聚化结构域的构象表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。

公开(公告)号：US20130084288A1

公开(公告)日：2013-04-04

申请号：US13669216

申请日：2012-11-05

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Kang Li ,  Yucheng Li ,  Sanjaya Singh ,  Bin-Bing Stephen Zhou

IPC: C07K16/28

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

公开(公告)号：US11434287B2

公开(公告)日：2022-09-06

申请号：US16682773

申请日：2019-11-13

Applicant: Genentech, Inc.

Inventor： Sek Chung Fung ,  Matthew Moyle ,  Mason Lu ,  Changning Yan ,  Sanjaya Singh ,  Dan Huang

IPC: A61K39/00 ,  C07K16/24

Abstract: The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.

公开(公告)号：US20180291090A1

公开(公告)日：2018-10-11

申请号：US15844245

申请日：2017-12-15

Applicant: GENENTECH, INC.

Inventor： Sek Chung Fung ,  Kang Li ,  Yucheng Li ,  Sanjaya Singh ,  Bin-Bing Stephen Zhou

IPC: C07K16/18 ,  C07K14/705

Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.

公开(公告)号：US20150376295A1

公开(公告)日：2015-12-31

申请号：US14792197

申请日：2015-07-06

Applicant: Genentech, Inc.

Inventor： Ling-Ling An ,  Sek Chung Fung ,  Robert F. Kelley ,  Henry B. Lowman ,  Sanjaya Singh ,  Herren Wu

IPC: C07K16/40

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/50 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

Abstract translation: 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。