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1.发明申请NOVEL ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE DETECTION AND DIAGNOSIS OF DISEASE 有权抗新药抗体及其在疾病的检测和诊断中的应用公开(公告)号：US20140057288A1
公开(公告)日：2014-02-27
申请号：US13942421
申请日：2013-07-15
Applicant: GENENTECH, INC.
Inventor： Kang Li , Sek Chung Fung , Zhengbin Yao
IPC: G01N33/574
CPC classification number: G01N33/57492 , C07K16/28 , C07K2317/56 , G01N33/574 , G01N33/57488 , G01N2333/705
Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。
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2.发明申请公开(公告)号：US20180291090A1
公开(公告)日：2018-10-11
申请号：US15844245
申请日：2017-12-15
Applicant: GENENTECH, INC.
Inventor： Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
IPC: C07K16/18 , C07K14/705
Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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3.发明申请ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES 审中-公开抗坏血酸激动剂抗体及其在治疗缺血性相关疾病中的应用公开(公告)号：US20140093889A1
公开(公告)日：2014-04-03
申请号：US13972443
申请日：2013-08-21
Applicant: Genentech, Inc.
Inventor： Kang Li , Bin-Bing Stephen Zhou , Wenjuan Wu , Sek Chung Fung , Sanjaya Singh
IPC: C07K16/30 , G01N33/574
CPC classification number: C07K16/30 , A61K39/00 , A61K39/39558 , A61K2039/505 , A61K2039/5152 , C07K16/00 , C07K16/28 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/75 , C07K2319/30 , G01N33/57492 , G01N33/6893
Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
Abstract translation: 本发明涉及特异性结合Notch 3并激活信号传导的激动剂抗体。 本发明包括与包含第一Lin12结构域的表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。
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Patent Agency Ranking
4.发明授权Anti-Notch3 agonist antibodies and their use in the treatment of Notch3-related diseases 有权抗Notch3激动剂抗体及其在治疗Notch3相关疾病中的应用公开(公告)号：US09518124B2
公开(公告)日：2016-12-13
申请号：US13972443
申请日：2013-08-21
Applicant: Genentech, Inc.
Inventor： Kang Li , Bin-Bing Stephen Zhou , Wenjuan Wu , Sek Chung Fung , Sanjaya Singh
IPC: A61K39/00 , C07K16/30 , C07K16/00 , C07K16/28 , G01N33/68 , G01N33/574 , A61K39/395
CPC classification number: C07K16/30 , A61K39/00 , A61K39/39558 , A61K2039/505 , A61K2039/5152 , C07K16/00 , C07K16/28 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/75 , C07K2319/30 , G01N33/57492 , G01N33/6893
Abstract: The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
Abstract translation: 本发明涉及特异性结合Notch 3并激活信号传导的激动剂抗体。 本发明包括与包含第一Lin12结构域的表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。
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5.发明申请ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES 有权ANTAGONIST ANTI-NOTCH3抗体及其在预防和治疗Notch3相关疾病中的应用公开(公告)号：US20130144040A1
公开(公告)日：2013-06-06
申请号：US13669230
申请日：2012-11-05
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
Abstract translation: 本发明涉及特异性结合Notch 3并抑制其活化的拮抗剂抗体。 本发明包括与包含第一Lin12结构域和第二二聚化结构域的构象表位结合的抗体。 本发明还包括这些抗体治疗或预防Notch 3相关疾病或病症的用途。
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6.发明申请公开(公告)号：US20130084288A1
公开(公告)日：2013-04-04
申请号：US13669216
申请日：2012-11-05
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
IPC: C07K16/28
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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公开(公告)号：US09873734B2
公开(公告)日：2018-01-23
申请号：US13669230
申请日：2012-11-05
Applicant: Genentech, Inc.
Inventor： Sek Chung Fung , Kang Li , Zhengbin Yao
IPC: A61K39/00 , C07K16/18 , C07K14/705 , C07K16/28
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/56 , C07K2317/76 , C07K2319/30
Abstract: The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
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公开(公告)号：US08956811B2
公开(公告)日：2015-02-17
申请号：US13942421
申请日：2013-07-15
Applicant: Genentech, Inc.
Inventor： Kang Li , Sek Chung Fung , Zhengbin Yao
IPC: C07K16/00 , C07K16/18 , C07K16/28 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/577 , A61K39/00 , A61K39/395
CPC classification number: G01N33/57492 , C07K16/28 , C07K2317/56 , G01N33/574 , G01N33/57488 , G01N2333/705
Abstract: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and kits comprising the antibodies for use in the detection and diagnosis.
Abstract translation: 本发明涉及与人Notch3特异性结合的新型抗体及其在检测和/或诊断Notch3相关疾病如癌症中的用途。 本发明还包括编码这些新型抗体的核酸，携带核酸的载体和细胞系，以及包含用于检测和诊断的抗体的试剂盒。
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