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公开(公告)号：US20180282282A1
公开(公告)日：2018-10-04
申请号：US15942333
申请日：2018-03-30
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
IPC: C07D217/22 , A61K31/472 , A61P35/00 , A61K45/06 , C07D401/04 , A61K31/4725 , A61K31/506 , A61K31/501 , C07D471/04 , C07D413/04 , C07D413/14 , A61K31/5377 , C07D417/04 , A61K31/4985 , C07D401/14 , C07D487/04 , A61K31/551 , C07D498/04 , A61K31/5383 , C07D405/14 , C07D519/00 , C07D498/14 , C07D513/04 , A61K31/554 , A61K31/55 , A61K31/549
Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
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公开(公告)号：US20170058049A1
公开(公告)日：2017-03-02
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US20150218176A1
公开(公告)日：2015-08-06
申请号：US14688724
申请日：2015-04-16
Applicant: Genentech, Inc.
Inventor： Daniel Burdick , Huifen Chen , Shumei Wang , Weiru Wang
IPC: C07D487/04 , A61K45/06 , A61K31/4985
CPC classification number: C07D487/04 , A61K31/4985 , A61K45/06
Abstract: Compounds having the formula I wherein R1 and R2 are as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Abstract translation: 具有式I的化合物，其中R 1和R 2如本文所定义，是ERK激酶的抑制剂。 还公开了用于治疗过度增殖性疾病的组合物和方法。
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公开(公告)号：US20140228277A1
公开(公告)日：2014-08-14
申请号：US14351525
申请日：2012-10-12
Applicant: GENENTECH, INC. , F. Hoffman-La Roche AG
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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公开(公告)号：US11566003B2
公开(公告)日：2023-01-31
申请号：US16921297
申请日：2020-07-06
Applicant: Genentech, Inc.
Inventor： Bryan Chan , Joy Drobnick , Lewis Gazzard , Timothy Heffron , Jun Liang , Sushant Malhotra , Rohan Mendonca , Naomi Rajapaksa , Craig Stivala , John Tellis , Weiru Wang , BinQing Wei , Aihe Zhou , Matthew W. Cartwright , Michael Lainchbury , Emanuela Gancia , Eileen Seward , Andrew Madin , David Favor , Kin Chiu Fong , Yonghan Hu , Andrew Good
IPC: C07D217/22 , A61K31/549 , A61P35/00 , A61K45/06 , C07D401/04 , A61K31/4725 , A61K31/506 , A61K31/501 , C07D471/04 , C07D413/04 , C07D413/14 , A61K31/5377 , C07D417/04 , A61K31/4985 , C07D401/14 , C07D487/04 , A61K31/551 , C07D498/04 , A61K31/5383 , C07D405/14 , C07D519/00 , C07D498/14 , C07D513/04 , A61K31/554 , A61K31/55 , A61K31/472 , C07D409/14 , C07D491/04 , C07D487/14
Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
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Patent Agency Ranking
公开(公告)号：US20220073520A1
公开(公告)日：2022-03-10
申请号：US17213362
申请日：2021-03-26
Applicant: Genentech, Inc.
Inventor： Sushant Malhotra , Michael Siu , Weiru Wang , BinQing Wei , Aihe Zhou , Bryan K. Chan , Lewis J. Gazzard , Timothy Heffron , Michael Lainchbury , Andrew Madin , Eileen Mary Seward , Matthew W. Cartwright , Emanuela Gancia , David Favor , Kin Chiu Fong , Andrew Good , Yonghan Hu
IPC: C07D487/04 , C07D403/04 , C07D401/04 , C07D405/14 , C07D237/28 , C07D401/14 , C07D417/04
Abstract: Cinnoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the cinnoline compounds.
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公开(公告)号：US09624269B2
公开(公告)日：2017-04-18
申请号：US14948173
申请日：2015-11-20
Applicant: GENENTECH, INC.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
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公开(公告)号：US20160304563A1
公开(公告)日：2016-10-20
申请号：US14948173
申请日：2015-11-20
Applicant: Genentech, Inc.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
IPC: C07K7/08
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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公开(公告)号：US09193766B2
公开(公告)日：2015-11-24
申请号：US14351525
申请日：2012-10-12
Applicant: GENENTECH, INC.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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公开(公告)号：US20140286963A1
公开(公告)日：2014-09-25
申请号：US14292461
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/40 , G01N33/573 , A61K47/48
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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