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公开(公告)号：US09453079B2
公开(公告)日：2016-09-27
申请号：US14292461
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/18 , A61K39/395 , C07K16/40 , A61K47/48 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US10696721B2
公开(公告)日：2020-06-30
申请号：US15944700
申请日：2018-04-03
Applicant: Genentech, Inc.
Inventor： Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
IPC: A61K9/50 , C07K14/00 , C07K14/415 , C07K14/81 , A61K38/00 , A61K47/34 , A61K38/16 , C07K14/47 , A61K9/00
Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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公开(公告)号：US09879094B2
公开(公告)日：2018-01-30
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07H21/04 , C07K16/18 , C12P21/08 , C07K16/40 , A61K39/395 , G01N33/573 , C12P21/00 , A61K47/68 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
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公开(公告)号：US20140212431A1
公开(公告)日：2014-07-31
申请号：US14133986
申请日：2013-12-19
Applicant: Genentech, Inc.
Inventor： Daniel K. Kirchhofer , Yingnan Zhang , Andrew Scott Peterson , Wei Li , Monica Kong-Beltran , Lijuan Zhou
IPC: C07K16/40 , A61K45/06 , A61K39/395
CPC classification number: C07K16/40 , A61K31/40 , A61K38/1808 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K14/485 , C07K2317/70 , C07K2319/30 , C12N9/6454 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/404 , A61K31/505
Abstract: The invention provides PCSK9-binding polypeptides and methods of using the same.
Abstract translation: 本发明提供PCSK9结合多肽及其使用方法。
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公开(公告)号：US10787484B2
公开(公告)日：2020-09-29
申请号：US16229226
申请日：2018-12-21
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: C07K7/06 , C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06 , A61K38/00
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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Patent Agency Ranking
公开(公告)号：US10428125B2
公开(公告)日：2019-10-01
申请号：US15267087
申请日：2016-09-15
Applicant: Genentech, Inc.
Inventor： Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
IPC: C07K14/415 , C07K14/00 , A61K38/16 , A61K9/00 , A61K47/34 , A61K38/00 , C07K14/81 , C07K14/47 , A61K9/50
Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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公开(公告)号：US20170058049A1
公开(公告)日：2017-03-02
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US20140228277A1
公开(公告)日：2014-08-14
申请号：US14351525
申请日：2012-10-12
Applicant: GENENTECH, INC. , F. Hoffman-La Roche AG
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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公开(公告)号：US11155586B2
公开(公告)日：2021-10-26
申请号：US16574917
申请日：2019-09-18
Applicant: Genentech, Inc.
Inventor： Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
IPC: C07K14/415 , C07K14/00 , A61K47/34 , A61K38/16 , A61K9/00 , A61K9/50 , C07K14/47 , C07K14/81 , A61K38/00
Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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公开(公告)号：US11034725B2
公开(公告)日：2021-06-15
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: A61K38/00 , C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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