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公开(公告)号：US20200283478A1
公开(公告)日：2020-09-10
申请号：US16883552
申请日：2020-05-26
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, Jr. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
IPC: C07K7/02 , C12N9/64 , C12Q1/37 , G01N33/573 , G01N33/92 , C40B40/10 , C07K14/00 , A61K47/62 , A61P3/06
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US20190177366A1
公开(公告)日：2019-06-13
申请号：US16229226
申请日：2018-12-21
Applicant: Genentech, Inc.
Inventor： Maureen Beresini , Daniel Burdick , Charles Eigenbrot, JR. , Daniel Kirchhofer , Robert Lazarus , Wei Li , John Quinn , Nicholas Skelton , Mark Ultsch , Yingnan Zhang
Abstract: The invention provides PCSK9 inhibitors, compositions comprising the PCSK9 inhibitors, and methods of identifying and using the PCSK9 inhibitors.
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公开(公告)号：US09139863B2
公开(公告)日：2015-09-22
申请号：US13829094
申请日：2013-03-14
Applicant: Genentech, Inc.
Inventor： Jacob E. Corn , Yingnan Zhang , Aaron H. Phillips
CPC classification number: C12Q1/37 , C07K14/00 , G01N2500/04
Abstract: Provided herein are conformationally stabilized ubiquitin proteins and methods for using the same to identify agents that bind to the stabilized ubiquitin protein or that bind to a protein that interacts with or processes the stabilized form of the ubiquitin protein. Also provided herein are methods for screening for conformationally stabilized proteins having increased binding affinity to a binding partner in comparison to the binding affinity of the wildtype form of the protein to the binding partner.
Abstract translation: 本文提供了构象稳定的泛素蛋白质及其使用方法，用于鉴定与稳定的泛蛋白结合的试剂或结合与泛素蛋白质的稳定化形式相互作用或处理的蛋白质。 本文还提供了与蛋白质的野生型形式与结合配偶体的结合亲和力相比较，筛选具有增加的结合亲和力的结构亲和力的构象稳定的蛋白质的方法。
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公开(公告)号：US20140235820A1
公开(公告)日：2014-08-21
申请号：US14265170
申请日：2014-04-29
Applicant: Genentech, Inc.
Inventor： Eric Bourhis , Andrea Cochran , Yingnan Zhang
CPC classification number: C07K7/06 , C07K7/08 , C07K7/64 , C07K14/001 , G01N33/92
Abstract: The invention provides methods and compositions for modulating the Wnt signaling pathway, in particular by interfering with binding of Dkk1 or SOST with LRP5 and/or LRP6.
Abstract translation: 本发明提供了调节Wnt信号通路的方法和组合物，特别是通过干扰Dkk1或SOST与LRP5和/或LRP6的结合。
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公开(公告)号：US11407794B2
公开(公告)日：2022-08-09
申请号：US16544394
申请日：2019-08-19
Applicant: Genentech, Inc.
Inventor： Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
IPC: C07K14/415 , C07K14/00 , A61K47/34 , A61K38/16 , A61K9/00 , A61K9/50 , C07K14/47 , C07K14/81 , A61K38/00
Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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Patent Agency Ranking
公开(公告)号：US11078243B2
公开(公告)日：2021-08-03
申请号：US16574910
申请日：2019-09-18
Applicant: Genentech, Inc.
Inventor： Rami Hannoush , Harini Kaluarachchi , Aaron Nile , Cameron Noland , Yingnan Zhang , Lijuan Zhou , Xinxin Gao
IPC: C07K14/415 , C07K14/00 , A61K47/34 , A61K38/16 , A61K9/00 , A61K9/50 , C07K14/47 , C07K14/81 , A61K38/00
Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.
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公开(公告)号：US20200172911A1
公开(公告)日：2020-06-04
申请号：US16724054
申请日：2019-12-20
Applicant: Genentech, Inc.
Inventor： Yingnan Zhang , Baris Bingol , Jacob Corn
IPC: C12N15/113 , A61K31/7088 , A61K45/06 , C07K7/08
Abstract: Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.
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公开(公告)号：US20180291380A1
公开(公告)日：2018-10-11
申请号：US15904177
申请日：2018-02-23
Applicant: Genentech, Inc.
Inventor： Yingnan Zhang , Baris Bingol Bingol , Jacob Corn
IPC: C12N15/113 , C07K7/08 , A61K45/06 , A61K31/7088 , A61K38/00
Abstract: Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.
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公开(公告)号：US09624269B2
公开(公告)日：2017-04-18
申请号：US14948173
申请日：2015-11-20
Applicant: GENENTECH, INC.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
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公开(公告)号：US20160304563A1
公开(公告)日：2016-10-20
申请号：US14948173
申请日：2015-11-20
Applicant: Genentech, Inc.
Inventor： Robert A. Lazarus , Yingnan Zhang , Weiru Wang
IPC: C07K7/08
CPC classification number: C07K7/08 , A61K38/00 , C07K16/38 , G01N33/6896 , Y02A50/465
Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
Abstract translation: 本发明提供了以非规范方式结合活性位点的BACE1肽抑制剂及其使用方法。
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