公开(公告)号：US12053525B2

公开(公告)日：2024-08-06

申请号：US17395400

申请日：2021-08-05

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: C07H21/04 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46 ,  G16B20/30 ,  G16B20/50 ,  A61K39/00 ,  G01N33/68 ,  G16B5/00 ,  G16B20/00

CPC classification number: A61K39/44 ,  A61K39/39558 ,  C07K16/468 ,  G16B20/30 ,  G16B20/50 ,  A61K39/3955 ,  A61K39/39566 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/56 ,  G01N33/6848 ,  G16B5/00 ,  G16B20/00

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US11116840B2

公开(公告)日：2021-09-14

申请号：US15789670

申请日：2017-10-20

Applicant: Genentech, Inc.

Inventor： Paul Carter ,  Christoph Spiess ,  Yiyuan Yin ,  Jianhui Zhou ,  Wendy Sandoval ,  Jacob Corn ,  Michael Dillon

IPC: A61K39/44 ,  C07K16/46 ,  A61K39/395 ,  G16B5/00 ,  G16B20/00 ,  A61K39/00 ,  G01N33/68

Abstract: Provided are, inter alia, multispecific antigen binding proteins, or antigen-binding fragments thereof, comprising one or more mutations in the VH/VL domains and/or CH1/CL domains, pharmaceutical compositions comprising same, isolated nucleic acids, vectors, and host cells encoding/expressing same, method of making the multispecific antigen binding proteins, computer readable media for evaluating multispecific antigen binding proteins, and libraries.

公开(公告)号：US20200172911A1

公开(公告)日：2020-06-04

申请号：US16724054

申请日：2019-12-20

Applicant: Genentech, Inc.

Inventor： Yingnan Zhang ,  Baris Bingol ,  Jacob Corn

IPC: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  C07K7/08

Abstract: Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.

公开(公告)号：US20180291380A1

公开(公告)日：2018-10-11

申请号：US15904177

申请日：2018-02-23

Applicant: Genentech, Inc.

Inventor： Yingnan Zhang ,  Baris Bingol Bingol ,  Jacob Corn

IPC: C12N15/113 ,  C07K7/08 ,  A61K45/06 ,  A61K31/7088 ,  A61K38/00

Abstract: Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.

公开(公告)号：US20150344888A1

公开(公告)日：2015-12-03

申请号：US14659204

申请日：2015-03-16

Applicant: GENENTECH, INC.

Inventor： Yingnan Zhang ,  Baris Bingol ,  Jacob Corn

IPC: C12N15/113 ,  A61K38/10 ,  C07K7/08 ,  A61K31/7088 ,  A61K45/06

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K38/00 ,  A61K45/06 ,  C07K7/08 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y301/02015 ,  C12Y304/19012 ,  A61K2300/00

Abstract: Inhibitors of USP30 and methods of using inhibitors of USP30 are provided. In some embodiments, methods of treating conditions involving mitochondrial defects are provided.

Abstract translation: 提供USP30的抑制剂和使用USP30抑制剂的方法。 在一些实施方案中，提供了治疗涉及线粒体缺陷的病症的方法。