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70 条记录 (耗时 0.028 秒)

    Benzoindoline compounds
    11.
    发明授权
    Benzoindoline compounds 失效
    苯并二氢吲哚化合物

    公开(公告)号：US06998403B2

    公开(公告)日：2006-02-14

    申请号：US10925712

    申请日：2004-08-25

    申请人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

    发明人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

    IPC分类号： A61K31/496 ,  C07D403/12

    CPC分类号： C07D209/60

    摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 and R4 represent hydrogen, or R1 and R4 represent hydrogen and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, or R1 and R2 represent hydrogen and R3 and R4 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, addition salts thereof with a pharmaceutically acceptable acid or base, and methods of treating conditions susceptible to α2-AR/5-HT2C antagonists.

    摘要翻译： 式（I）化合物：化学式id =“CHEM-US-00001”num =“000

    Benzopyran compounds as 5-HT.sub.2C receptor antagonists
    13.
    发明授权
    Benzopyran compounds as 5-HT.sub.2C receptor antagonists 失效
    苯并吡喃化合物作为5-HT2C受体拮抗剂

    公开(公告)号：US5723484A

    公开(公告)日：1998-03-03

    申请号：US786504

    申请日：1997-01-21

    申请人： Gilbert Lavielle ,  Thierry Dubuffet ,  Mark Millan ,  Adrian Newman-Tancredi

    发明人： Gilbert Lavielle ,  Thierry Dubuffet ,  Mark Millan ,  Adrian Newman-Tancredi

    IPC分类号： A61K31/40 ,  A61K31/435 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  A61P25/30 ,  A61P43/00 ,  C07D491/04 ,  C07D491/052 ,  C07D491/52

    CPC分类号： C07D491/04

    摘要： Compounds of formula (I): ##STR1## in which: n represents 1 or 2, R.sub.1 represents hydrogen or alkyl, benzyl, acetyl, benzoyl, allyl, pyridinecarbonyl, pyridinemethyl, acylaminoalkyl (optionally substituted), pyridineaminocarbonyl, phthalimidoalkyl, thiochromanyloxyalkyl or (benzodioxanyloxy)alkyl, R.sub.2, R.sub.3 or R.sub.4, which may be identical or different, represent hydrogen or halogen or alkyl, alkoxy, hydroxyl, acetyl, aminocarbonyl, aminomethyl, cyano, nitro, amino, phenyl (which may or may not be substituted), furyl, pyridinyl, thienyl or pyridyl, or alternatively, when they are located on adjacent carbons, R.sub.2 and R.sub.3 form, with the carbon atoms which bear them, a furan or phenyl ring, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful for the treatment of diseases requiring a ligand to the 5-HT.sub.2C receptors.

    摘要翻译： 乙酰基，苯甲酰基，烯丙基，吡啶羰基，吡啶甲基，酰氨基烷基（任意取代的），吡啶氨基羰基，苯二甲酰亚氨基烷基， 可以相同或不同的二氢苯并二氢吡喃基氧基烷基或（苯并二氧代氧基）烷基，R2，R3或R4代表氢或卤素或烷基，烷氧基，羟基，乙酰基，氨基羰基，氨基甲基，氰基，硝基，氨基，苯基（可以或不可以 或呋喃基，吡啶基，噻吩基或吡啶基，或者当它们位于相邻的碳上时，R2和R3与它们携带的碳原子一起形成呋喃或苯环，其异构体及其加成盐 与药学上可接受的酸和含有该药物的药物可用于治疗需要5-HT 2C受体配体的疾病。

    Substituted hydrochromenopyrroles
    18.
    发明授权
    Substituted hydrochromenopyrroles 失效
    取代的氢色谱

    公开(公告)号：US06365605B1

    公开(公告)日：2002-04-02

    申请号：US09480038

    申请日：2000-01-10

    申请人： Gilbert Lavielle ,  Thierry Dubuffet ,  Patrick Hautefaye ,  Françoise Lejeune ,  Mark Millan

    发明人： Gilbert Lavielle ,  Thierry Dubuffet ,  Patrick Hautefaye ,  Françoise Lejeune ,  Mark Millan

    IPC分类号： A61K3144

    CPC分类号： C07D491/04

    摘要： Compounds of formula (I): wherein: m is 0 to 3 inclusive, n is 0 to 3 and 2≦m+n≦3, p is 1 to 6 inclusive, X represents cyano or —CO—NR4R5, R4 and R5 being selected from hydrogen, linear or branched (C1-C6)-alkyl, (C3-C7)-cycloalkyl, and aryl, R1 and R2 each independently represent hydrogen or linear or branched (C1-C6)-alkyl, R3 represents hydrogen, optionally substituted phenyl, naphthyl or heteroaryl, or aryloxy or arylthio, or aryl or heteroaryl substituted by A′-Cy, A′ and Cy being as defined in the description, and medicinal products containing the same which are useful as D3 receptor ligands.

    摘要翻译： 式（I）的化合物：其中：m为0〜3，n为0〜3，2 <= m + n <= 3，p为1〜6，X表示氰基或-CO-NR 4 R 5， R 5选自氢，直链或支链（C 1 -C 6） - 烷基，（C 3 -C 7） - 环烷基和芳基，R 1和R 2各自独立地表示氢或直链或支链（C 1 -C 6） - 烷基，R 3表示氢 ，任选取代的苯基，萘基或杂芳基，或芳氧基或芳硫基，或被A'-Cy，A'和Cy取代的芳基或杂芳基如说明书中所定义，和含有它们的可用作D3受体配体的医药产品。

    Substituted hydrochromenopyridines
    19.
    发明授权
    Substituted hydrochromenopyridines 有权
    取代的氢氯苯并吡啶

    公开(公告)号：US06326377B1

    公开(公告)日：2001-12-04

    申请号：US09480037

    申请日：2000-01-10

    申请人： Gilbert Lavielle ,  Thierry Dubuffet ,  Patrick Hautefaye ,  Françoise Lejeune ,  Mark Millan

    发明人： Gilbert Lavielle ,  Thierry Dubuffet ,  Patrick Hautefaye ,  Françoise Lejeune ,  Mark Millan

    IPC分类号： A61K3144

    CPC分类号： C07D491/04

    摘要： Compounds of formula (I): wherein: m is 0 to 3 inclusive, n is 0 to 3 and 2≦m+n≦3, p is 1 to 6 inclusive, X represents cyano or —CO—NR4R5, R4 and R5 being selected from hydrogen, linear or branched (C1-C6)-alkyl, (C3-C7)-cycloalkyl,and aryl, R1 and R2 each independently represent hydrogen or linear or branched (C1-C6)-alkyl, R3 represents hydrogen, optionally substituted phenyl, naphthyl or heteroaryl, or aryloxy or arylthio, or aryl or heteroaryl substituted by A′—Cy, A′ and Cy being as defined in the description, and medicinal products containing the same which are useful as D3 receptor ligands.

    摘要翻译： 式（I）的化合物：其中：m为0〜3，n为0〜3，2 <= m + n <= 3，p为1〜6，X表示氰基或-CO-NR 4 R 5， R 5选自氢，直链或支链（C 1 -C 6） - 烷基，（C 3 -C 7） - 环烷基和芳基，R 1和R 2各自独立地表示氢或直链或支链（C 1 -C 6） - 烷基，R 3表示氢 ，任选取代的苯基，萘基或杂芳基，或芳氧基或芳硫基，或被A'-Cy，A'和Cy取代的芳基或杂芳基如说明书中所定义，和含有它们的可用作D3受体配体的医药产品。