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    MIXTURES OF HMOs
    12.
    发明申请
    MIXTURES OF HMOs 审中-公开

    公开(公告)号：US20190290667A1

    公开(公告)日：2019-09-26

    申请号：US16435949

    申请日：2019-06-10

    Applicant: Glycom A/S

    Inventor： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC: A61K31/702 ,  C12P19/26 ,  C07H5/06 ,  A61K31/715 ,  A61K31/7016 ,  C12P19/18

    Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

    MIXTURES OF HUMAN MILK OLIGOSACCHARIDES COMPRISING 3 '-O-SIALYLLACTOSE
    13.
    发明申请
    MIXTURES OF HUMAN MILK OLIGOSACCHARIDES COMPRISING 3 '-O-SIALYLLACTOSE 审中-公开

    公开(公告)号：US20180078574A1

    公开(公告)日：2018-03-22

    申请号：US15561684

    申请日：2016-03-31

    Applicant: Glycom A/S

    Inventor： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC: A61K31/702 ,  A61K31/7016 ,  C12P19/26 ,  C12P19/14

    Abstract: A mixture of human milk oligosaccharides that consists essentially of 3′-O-sialyllactose, a component A which is either 3-O-fucosyllactose or lacto-N-tetraose, a component B which is 3-O-fucosyl-3′-O-sialyllactose when component A is 3-O-fucosyllactose and sialyllacto-N-tetraose a, when component A is lacto-N-tetraose and optionally lactose as a fourth component. The mixtures are made by treating 3′-O-sialyllactose and component A with an α2,3-transsialidase. The mixtures are for use in anti-bacterial and anti-viral compositions, and for promoting the development of Bifidobacterium and Barnesiella.

    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE
    16.
    发明申请
    METHOD FOR MAKING A PRECURSOR OF L-FUCOSE FROM D-GLUCOSE 审中-公开
    从D-葡萄糖制备L-赖氨酸前体的方法

    公开(公告)号：US20140235848A1

    公开(公告)日：2014-08-21

    申请号：US14348014

    申请日：2012-09-28

    Applicant: Glycom A/S

    Inventor： Julien BOUTET ,  Nikolay KHANZHIN ,  Filippo BONACCORSI ,  Gyula DEKANY

    IPC: C07H9/02 ,  C07H13/04 ,  C07H11/00 ,  C07H13/08

    CPC classification number: C07H9/02 ,  C07H1/00 ,  C07H3/02 ,  C07H9/04 ,  C07H11/00 ,  C07H13/04 ,  C07H13/08 ,  Y02P20/55

    Abstract: A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R2 is acyloxy and R3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.

    Abstract translation: 一种可用于从D-葡萄糖制备L-岩藻糖的前体的方法，其包括以下步骤：a）从D-葡萄糖制备式（1）化合物，式（1）其中R1为酰氧基，Q为 （a），（b），（c）或（d），式（a），（b），（c）或（d）或其中R 1是OH，Q是基团（e） f）或（g）; 式（e），（f）或（g）其中R 2是酰氧基，R 3是磺酰基离去基团; 和b）从步骤a）中形成的式（1）化合物生产6-脱氧-L-托洛糖，其中所述部分是高亲脂性保护基; 提供了式（1）化合物和使用式（1）化合物。

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