公开(公告)号：US20180002363A1

公开(公告)日：2018-01-04

申请号：US15703551

申请日：2017-09-13

Applicant: GLYCOM A/S

Inventor： Martin MATWIEJUK ,  Markus HEDEROS

IPC: C07H1/08 ,  C12P19/04 ,  C07H23/00 ,  C12P19/18 ,  B01D15/36

Abstract: The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

公开(公告)号：US20160075729A1

公开(公告)日：2016-03-17

申请号：US14783783

申请日：2014-04-11

Applicant: GLYCOM A/S

Inventor： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Markus HEDEROS ,  Elise CHAMPION ,  Martin MATWIEJUK ,  Gyula DEKANY

IPC: C07H5/04

CPC classification number: C07H5/04 ,  C07H1/00

Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

Abstract translation: 其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选被一个或多个甲基， 三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH，其中R 选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液烷基，R4选自H和岩藻糖基，条件是R3和R4中至少一个为H，A为二价 碳水化合物接头，对制药和食品工业具有重要的生物活性和显着的商业价值。

公开(公告)号：US20180362569A1

公开(公告)日：2018-12-20

申请号：US16063367

申请日：2016-12-16

Applicant: Glycom A/S

Inventor： Martin MATWIEJUK ,  Pierre CHASSAGNE ,  Markus HEDEROS

IPC: C07H1/06 ,  C07H13/04 ,  A23L33/00 ,  A23L33/125

Abstract: The invention relates to crystalline polymorphs of lacto-N-tetraose (LNT) and methods for making the same for use in pharmaceutical compositions, nutritional formulations and food supplements.

公开(公告)号：US20170369920A1

公开(公告)日：2017-12-28

申请号：US15536537

申请日：2015-12-16

Applicant: Glycom A/S

Inventor： Gyula DEKANY ,  Györgyi OSZTROVSZKY ,  Martin MATWIEJUK ,  Pierre CHASSAGNE ,  Markus HEDEROS

IPC: C12P19/18 ,  C07H3/06 ,  C07H1/06

Abstract: The invention relates to a method for selective crystallization of 2′-FL from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution.

公开(公告)号：US20170340654A1

公开(公告)日：2017-11-30

申请号：US15532747

申请日：2015-12-04

Applicant: Glycom A/S

Inventor： Pierre CHASSAGNE ,  Martin MATWIEJUK ,  Markus HEDEROS ,  Györgyi OSZTROVSZKY ,  Gyula DEKANY

IPC: A61K31/702 ,  C07H3/06 ,  C07H1/06

CPC classification number: A61K31/702 ,  A61K31/7024 ,  C07H1/06 ,  C07H3/06 ,  C07H15/18 ,  Y02A50/473

Abstract: Crystalline difucosyllactose, useful in a pharmaceutical composition and a nutritional composition, is disclosed.