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    CRYSTALLINE CARBOHYDRATE DERIVATIVE
    1.
    发明申请
    CRYSTALLINE CARBOHYDRATE DERIVATIVE 审中-公开
    碳水化合物衍生物

    公开(公告)号：US20140378679A1

    公开(公告)日：2014-12-25

    申请号：US14321486

    申请日：2014-07-01

    申请人： GLYCOM A/S

    发明人： Gyula DEKANY ,  Károly ÁGOSTON ,  István BAJZA ,  Marie BØJSTRUP ,  Ignacio FIGUEROA PÉREZ ,  Lars KRÖGER ,  Christoph H. RÖHRIG

    IPC分类号： C07H5/06 ,  C07H1/00

    CPC分类号： C07H5/06 ,  C07H1/00

    摘要： α-Lactosamine hydrochloride, substantially free of β-lactosamine hydrochloride; a method of preparing α-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lactosamine hydrochloride, water and at least one water-miscible organic solvent at a temperature of 0-100° C., and cooling the solution to cause crystallisation of α-lactosamine hydrochloride monohydrate; a method of preparing anhydrous α-lactosamine hydrochloride; and use of α-lactosamine hydrochloride as a food supplement or intermediate in synthesis.

    摘要翻译： α-乳糖胺盐酸盐，基本上不含β-乳糖胺盐酸盐; 一种从乳糖胺盐酸盐的端基异构体混合物制备α-乳糖胺盐酸盐一水合物的方法，包括：在0-100℃的温度下制备包括乳糖胺盐酸盐，水和至少一种水混溶性有机溶剂的端基异构体混合物的溶液 ，并冷却该溶液以引起α-乳糖胺盐酸盐一水合物的结晶; 制备无水α-乳糖胺盐酸盐的方法; 并使用盐酸α-乳糖胺作为食品添加剂或中间体。

    MIXTURES OF HMOs
    6.
    发明申请
    MIXTURES OF HMOs 审中-公开

    公开(公告)号：US20170312298A1

    公开(公告)日：2017-11-02

    申请号：US15521582

    申请日：2015-10-23

    申请人： Glycom A/S

    发明人： Elise CHAMPION ,  Bruce MCCONNELL ,  Gyula DEKANY

    IPC分类号： A61K31/702 ,  C12P19/18 ,  A61K31/715 ,  C12P19/26 ,  A61K31/7016

    CPC分类号： A61K31/702 ,  A61K31/7016 ,  A61K31/715 ,  C12P19/18 ,  C12P19/26 ,  C12Y204/01065 ,  A61K2300/00

    摘要： The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

    DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF
    7.
    发明申请
    DIVERSIFICATION OF HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF 有权
    人乳清蛋白（HMOs）或其前体的多样性

    公开(公告)号：US20160289721A1

    公开(公告)日：2016-10-06

    申请号：US15161887

    申请日：2016-05-23

    申请人： GLYCOM A/S

    发明人： Gyula DEKANY ,  Elise Champion ,  Markus Hederos

    IPC分类号： C12P19/14 ,  C12P19/12 ,  C12P19/04

    CPC分类号： C12P19/14 ,  C07H1/00 ,  C07H5/04 ,  C07H13/04 ,  C12P19/04 ,  C12P19/12

    摘要： A method of diversification of human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprises a) providing at least one compound or a mixture of the compounds selected from the group consisting of: optionally sialylated and/or fucosylated lactose derivatives of general formula 2 and salts thereof; b) adding at least one enzyme comprising a transglycosidase activity to the at least one compound or a mixture of compounds provided according to step a); and c) incubating the mixture obtained according to step b).

    摘要翻译： 人乳寡糖（HMO）或其前体多样化的方法，可通过该方法获得的化合物以及涉及这些化合物的用途和组合物。 该方法包括：a）提供至少一种化合物或选自下组的化合物或混合物：选自唾液酸化的和/或通式2的岩藻糖化的乳糖衍生物及其盐; b）向所述至少一种化合物或根据步骤a）提供的化合物的混合物中加入至少一种包含转糖苷酶活性的酶; 和c）孵育根据步骤b）获得的混合物。

    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES
    8.
    发明申请
    SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES 有权
    异亮氨酸/ FOSOSLIL人乳酪寡糖的合成

    公开(公告)号：US20160075729A1

    公开(公告)日：2016-03-17

    申请号：US14783783

    申请日：2014-04-11

    申请人： GLYCOM A/S

    发明人： Pierre CHASSAGNE ,  Nikolay KHANZHIN ,  Markus HEDEROS ,  Elise CHAMPION ,  Martin MATWIEJUK ,  Gyula DEKANY

    IPC分类号： C07H5/04

    CPC分类号： C07H5/04 ,  C07H1/00

    摘要： An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N3 and —OR6 wherein R6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH2)n—NH2 and —(CH2)n—N3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO3H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R2 is selected from H and fucosyl, R3 is selected from H and sialyl, R4 is selected from H and fucosyl, provided that at least one of R3 and R4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

    摘要翻译： 其中R选自-OH，-N 3和-OR 6，其中R 6选自任选被一个或多个甲基取代的烯丙基，炔丙基任选被一个或多个甲基， 三甲基甲硅烷基 - 乙基， - （CH 2）n -NH 2和 - （CH 2）n -N 3其中整数n为10，优选2或3，R选自唾液酰基部分，-SO 3 H和-CH（R）-COOH，其中R 选自H，烷基和苄基，R2选自H和岩藻糖基，R3选自H和唾液烷基，R4选自H和岩藻糖基，条件是R3和R4中至少一个为H，A为二价 碳水化合物接头，对制药和食品工业具有重要的生物活性和显着的商业价值。

    METHOD FOR MAKING N-SUBSTITUTED MANNOSAMINE DERIVATIVES
    9.
    发明申请
    METHOD FOR MAKING N-SUBSTITUTED MANNOSAMINE DERIVATIVES 审中-公开
    制备N-取代的曼诺糖胺衍生物的方法

    公开(公告)号：US20150329579A1

    公开(公告)日：2015-11-19

    申请号：US14651573

    申请日：2013-12-20

    申请人： GLYCOM A/S

    发明人： Ioannis VRASIDAS ,  Gábor VLÁD ,  Gyula DEKANY

    IPC分类号： C07H5/06

    CPC分类号： C07H5/06 ,  C07H15/18

    摘要： A method for making an N-substituted D-mannosamine derivative of the following formula 1 and its salts wherein R1 is a non-electron-withdrawing group, and wherein R2 is —OH or R2 is —NHR3 wherein R3 is a group removable by hydrogenolysis; by epimerizing an N-substituted D-glucosamine derivative of the following formula 2 wherein R1 and R2 are as defined above.

    摘要翻译： 制备下式1的N-取代的D-甘露糖胺衍生物及其盐的方法，其中R1是非吸电子基团，其中R2是-OH或R2是-NHR3，其中R3是通过氢解除去的基团 ; 通过将下式2的N-取代的D-葡糖胺衍生物差向异构化，其中R 1和R 2如上所定义。