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公开(公告)号：US08288541B2
公开(公告)日：2012-10-16
申请号：US12186555
申请日：2008-08-06
申请人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright , Rene Wyler
发明人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright , Rene Wyler
IPC分类号： C07D241/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , A61K31/497 , A61P1/16 , A61P1/18 , A61P3/06 , A61P3/10
CPC分类号： C07D241/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型哌嗪酰胺衍生物，其中R 1至R 11，W，X和Y如说明书和权利要求书中所定义，以及其生理学上可接受的盐。 这些化合物与LXRα和LXRβ结合，可用作药物。
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公开(公告)号：US07625902B2
公开(公告)日：2009-12-01
申请号：US12053674
申请日：2008-03-24
申请人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright
发明人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright
IPC分类号： A61K31/496 , A61K31/498 , C07D233/32 , C07D401/12 , C07D403/12 , C07D495/04
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention is concerned with novel imidazolidinone derivatives of formula (I): wherein R1 to R11 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used in pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的新型咪唑烷酮衍生物：其中R 1至R 11和X如说明书和权利要求书中所定义，以及其生理学上可接受的盐。 这些化合物与LXRα和LXRβ结合，可用于药物组合物。
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公开(公告)号：US20080242677A1
公开(公告)日：2008-10-02
申请号：US12053674
申请日：2008-03-24
申请人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright
发明人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright
IPC分类号： A61K31/496 , C07D403/06 , C07D401/06 , A61K31/454
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The invention is concerned with novel imidazolidinone derivatives of formula (I): wherein R1 to R11 and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used in pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的新型咪唑啉酮衍生物：其中R 1至R 11和X如说明书和权利要求书中所定义，以及 其生理上可接受的盐。 这些化合物与LXRα和LXRβ结合，可用于药物组合物。
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公开(公告)号：US20090048264A1
公开(公告)日：2009-02-19
申请号：US12186555
申请日：2008-08-06
申请人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright , Rene Wyler
发明人： Henrietta Dehmlow , Bernd Kuhn , Ulrike Obst Sander , Stephan Roever , Tanja Schulz-Gasch , Matthew Wright , Rene Wyler
IPC分类号： A61K31/497 , A61P3/00 , A61P29/00 , A61P17/00 , A61P35/00 , C07D403/06 , A61K31/4545 , C07D401/14 , C07D409/14 , C07D401/06 , C07D413/14
CPC分类号： C07D241/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型哌嗪酰胺衍生物，其中R 1至R 11，W，X和Y如说明书和权利要求书中所定义，以及其生理学上可接受的盐。 这些化合物与LXRα和LXRβ结合，可用作药物。
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公开(公告)号：US20050096337A1
公开(公告)日：2005-05-05
申请号：US10978155
申请日：2004-10-29
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
IPC分类号： C07D213/30 , C07D213/32 , C07D213/38 , C07D213/56 , C07D213/82 , C07D237/08 , C07D239/26 , C07D239/28 , C07D241/12 , A61K31/44 , A61K31/19 , A61K31/215 , A61K31/277
CPC分类号： C07D213/30 , C07D213/32 , C07D213/38 , C07D213/56 , C07D213/82 , C07D237/08 , C07D239/26 , C07D239/28 , C07D241/12
摘要： This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译： 本发明涉及下式的化合物，其中R 5，R 6和R 7中的一个是X 1和X 2 >，X 2，Y 1至Y 4，R 1至R 13中的至少1个 >和m和n在说明书中定义，以及所有对映异构体及其药学上可接受的盐和/或酯。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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公开(公告)号：US20050203160A1
公开(公告)日：2005-09-15
申请号：US11074474
申请日：2005-03-08
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
IPC分类号： C07D403/12 , C07D43/02 , A61K31/416
CPC分类号： C07D403/12
摘要： This invention relates to compounds of the formula I: wherein one of R6, R7 and R8 is and R1 to R15 and n are as defined in the description, and all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.
摘要翻译： 本发明涉及式I化合物：其中R 6，R 7和R 8中的一个是R 1和R 2， R 15和R 15如在说明书中所定义，以及所有对映异构体及其药学上可接受的盐和/或酯。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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17.发明申请公开(公告)号：US20050096336A1
公开(公告)日：2005-05-05
申请号：US10977651
申请日：2004-10-29
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
IPC分类号： C07D213/30 , C07D213/38 , C07D239/26 , A61K31/44 , A61K31/192 , A61K31/277 , A61K31/343 , A61K31/381
CPC分类号： C07D213/30 , C07D213/38 , C07D239/26
摘要： There are presented compounds of the formula wherein R6 and R7 is R4 and R5 or R5 and R6 together with the carbon atoms to which they are attached, form a ring as defined in the description and X1, X2, Y1 to Y4, R1 to R13 and n are as specified in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译： 提出下式的化合物其中R 6和R 7是R 4和R 5或R 5， SUP> 5和R 6以及它们所连接的碳原子一起形成如说明书中所定义的环，X 2 ，Y 1至Y 4，R 1至R 13和n分别为 在本说明书中指定，以及所有对映异构体及其药学上可接受的盐和/或酯。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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公开(公告)号：US20050245589A1
公开(公告)日：2005-11-03
申请号：US11114404
申请日：2005-04-26
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
IPC分类号： A61K31/41 , C07D231/12 , A61K31/415 , C07D231/10
CPC分类号： C07D231/12
摘要： The invention relates to compounds of the formula I: wherein one of R5, R6 and R7 is and X1, X2, R1 to R15 and n are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR δ and/or PPARα agonists.
摘要翻译： 本发明涉及式I化合物：其中R 5，R 6和R 7中的一个为和X 1， R 1，R 2和R 2如本说明书中所定义，和其药学上可接受的盐和/或酯 其中。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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19.发明申请Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents 失效噻唑基 - 吲哚衍生物，其制造和用作药剂公开(公告)号：US20050004187A1
公开(公告)日：2005-01-06
申请号：US10878473
申请日：2004-06-28
申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
发明人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Wright
IPC分类号： A61P3/04 , A61P3/10 , C07D417/12 , A61K31/426 , C07D417/02
CPC分类号： C07D417/12
摘要： This invention relates to compounds of the formula wherein one of R6, R7 or R8 is and all enantiomers and pharmaceutically acceptable salts and/or esters thereof as well as pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译： 本发明涉及下式的化合物，其中R 6，R 7或R 8中的一个为其所有对映异构体及其药学上可接受的盐和/或酯，以及含有这些化合物的药物组合物， 用于其制备和用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病。
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公开(公告)号：US08039493B2
公开(公告)日：2011-10-18
申请号：US12211835
申请日：2008-09-17
IPC分类号： A61K31/38 , A61K31/18 , C07C311/16 , C07D333/22
CPC分类号： C07C311/03 , C07C311/16 , C07C311/19 , C07D213/40 , C07D271/10 , C07D277/28 , C07D307/52 , C07D333/02 , C07D333/22 , C07D409/12
摘要： The invention is concerned with novel biaryl sulfonamide derivatives of formula (I) wherein R1 to R3 and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型联芳基磺酰胺衍生物，其中R 1至R 3和Y如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物与LXRα和LXRβ结合，可用作药物。
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