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公开(公告)号：US08648037B2
公开(公告)日：2014-02-11
申请号：US13237120
申请日：2011-09-20
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
CPC分类号： C07K5/123 , A61K38/00 , A61K38/12 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0823 , C07K5/0827 , C07K14/811
摘要： The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US08481483B2
公开(公告)日：2013-07-09
申请号：US12708671
申请日：2010-02-19
申请人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
发明人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
摘要： The present invention provides cyclosporin analogues of formula I, and compositions comprising these compounds, as well as processes for their preparation, intermediates in their synthesis, and methods of use thereof for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.
摘要翻译： 本发明提供式I的环孢菌素类似物，以及包含这些化合物的组合物，以及其制备方法，其合成中的中间体及其用于预防器官移植排斥反应，免疫疾病和炎症的治疗的方法和 治疗病毒（特别是丙型肝炎病毒）感染。
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公开(公告)号：US20120070416A1
公开(公告)日：2012-03-22
申请号：US13237120
申请日：2011-09-20
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
IPC分类号： A61K38/12 , A61P31/14 , A61K38/21 , A61K38/46 , A61P37/02 , A61K38/48 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , C07K7/56 , A61K38/45
CPC分类号： C07K5/123 , A61K38/00 , A61K38/12 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0823 , C07K5/0827 , C07K14/811
摘要： The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20110123496A1
公开(公告)日：2011-05-26
申请号：US12907614
申请日：2010-10-19
申请人： Yonghua Gai , Yat Sun Or , Guoqiang Wang
发明人： Yonghua Gai , Yat Sun Or , Guoqiang Wang
IPC分类号： A61K38/12 , C07K5/087 , C07D498/22 , A61P31/12 , A61P31/14 , A61K38/21 , A61K39/00 , C07K1/00 , C12N7/06
CPC分类号： C07D498/22 , A61K31/495 , A61K45/06
摘要： The present invention discloses compounds of formula Ia or Ib or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式Ia或Ib的化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20110008286A1
公开(公告)日：2011-01-13
申请号：US12832383
申请日：2010-07-08
申请人： Guoqiang Wang , Yat Sun Or , Jiang Long , Xuri Gao
发明人： Guoqiang Wang , Yat Sun Or , Jiang Long , Xuri Gao
IPC分类号： A61K38/21 , C07K7/64 , A61K38/12 , A61P31/12 , A61P37/06 , A61P19/02 , A61P29/00 , A61P17/06 , A61P11/06
CPC分类号： C07K7/645 , A61K38/00 , Y02A50/463
摘要： The present invention provides novel proline substituted cyclosporinanalogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections.
摘要翻译： 本发明提供了新的脯氨酸取代的环孢菌素化合物，包含这些化合物的药物组合物和使用这些化合物治疗疾病和疾病，包括免疫疾病，炎症性疾病和病毒感染的方法。
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公开(公告)号：US07402568B2
公开(公告)日：2008-07-22
申请号：US11236043
申请日：2005-09-27
申请人： Yat Sun Or , Yao-Ling Qiu , Guoqiang Wang , Deqiang Niu , Ly Tam Phan
发明人： Yat Sun Or , Yao-Ling Qiu , Guoqiang Wang , Deqiang Niu , Ly Tam Phan
CPC分类号： C07H17/08
摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07189704B2
公开(公告)日：2007-03-13
申请号：US11154260
申请日：2005-06-16
申请人： Deqiang Niu , Guoqiang Wang , Yat Sun Or , Ly Tam Phan
发明人： Deqiang Niu , Guoqiang Wang , Yat Sun Or , Ly Tam Phan
CPC分类号： C07H17/08 , A61K31/7052 , A61K45/06 , Y02A50/401 , Y02A50/478 , A61K2300/00
摘要： The present invention discloses, inter alia, a compound of the following formula, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the aforementioned compounds. The invention further includes processes by which to make the compounds of the present invention.
摘要翻译： 本发明尤其公开了下式的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含上述化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US07022679B2
公开(公告)日：2006-04-04
申请号：US10758409
申请日：2004-01-14
申请人： Heejin Kim , Guoqiang Wang , Yat Sun Or , Zhe Wang
发明人： Heejin Kim , Guoqiang Wang , Yat Sun Or , Zhe Wang
IPC分类号： C07H17/08
CPC分类号： C07D401/04 , C07H17/08
摘要： The present invention relates to processes and intermediates for the preparation of 6–11 bicyclic erythromycin derivatives. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (IX-c):
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公开(公告)号：US06696494B2
公开(公告)日：2004-02-24
申请号：US10007235
申请日：2001-10-22
申请人： Yat Sun Or , Guoqiang Wang , John Rougas , Jude Elizabeth Mathews , Kate Ryan Muldoon , Vincent Alfred Boyd , Jens Werner Eckstein , Steven Wayne Riesinger
发明人： Yat Sun Or , Guoqiang Wang , John Rougas , Jude Elizabeth Mathews , Kate Ryan Muldoon , Vincent Alfred Boyd , Jens Werner Eckstein , Steven Wayne Riesinger
IPC分类号： A61K31165
CPC分类号： C07D295/192 , C07C235/42 , C07C235/52 , C07C235/74 , C07C235/76 , C07C235/84 , C07C237/12 , C07C237/36 , C07C271/22 , C07C275/24 , C07C275/28 , C07C275/30 , C07C311/06 , C07C311/19 , C07C311/51 , C07C323/60 , C07C333/04 , C07C2601/14 , C07D213/65 , C07D213/71 , C07D215/36 , C07D261/08 , C07D271/12 , C07D279/30 , C07D295/215 , C07D307/20 , C07D311/24 , C07D333/34
摘要： Acylated &agr;-hydroxyarylbutanamines and related sulfonamides, ureas and carbamates that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds. The compounds have the formula: A representative example is:
摘要翻译： 公开了抑制天冬氨酰蛋白酶的酰化α-羟基芳基丁胺和相关磺酰胺，脲和氨基甲酸酯，以及使用这些化合物治疗疾病，特别是HIV的方法。 化合物具有以下化学式：代表性的实例是：
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公开(公告)号：US06673821B2
公开(公告)日：2004-01-06
申请号：US10007342
申请日：2001-10-22
申请人： Guoqiang Wang , Yat Sun Or , John Rougas , Steven Wayne Riesinger
发明人： Guoqiang Wang , Yat Sun Or , John Rougas , Steven Wayne Riesinger
IPC分类号： A61K31426
CPC分类号： C07D417/12 , C07D277/04
摘要： Nitrogen heterocycles that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds. The compounds have the formula: A representative example is:
摘要翻译： 公开了抑制天冬氨酰蛋白酶的氮杂环，使用这些化合物治疗疾病，特别是HIV的方法也是公开的。 化合物具有以下化学式：代表性的实例是：
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