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公开(公告)号：US08648037B2
公开(公告)日：2014-02-11
申请号：US13237120
申请日：2011-09-20
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
CPC分类号： C07K5/123 , A61K38/00 , A61K38/12 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0823 , C07K5/0827 , C07K14/811
摘要： The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20120070416A1
公开(公告)日：2012-03-22
申请号：US13237120
申请日：2011-09-20
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , Jiang Long , Bin Wang
IPC分类号： A61K38/12 , A61P31/14 , A61K38/21 , A61K38/46 , A61P37/02 , A61K38/48 , A61P31/12 , A61P31/04 , A61P31/10 , A61P35/00 , C07K7/56 , A61K38/45
CPC分类号： C07K5/123 , A61K38/00 , A61K38/12 , A61K45/06 , C07K5/06034 , C07K5/0808 , C07K5/0823 , C07K5/0827 , C07K14/811
摘要： The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。
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公开(公告)号：US20120237480A1
公开(公告)日：2012-09-20
申请号：US13422268
申请日：2012-03-16
申请人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
发明人： YAT SUN OR , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
IPC分类号： A61K31/706 , C07H19/12 , C07H19/173 , C07H19/044 , C07H19/10 , C07H19/20 , C07H19/11 , C07H19/213 , A61K31/7076 , A61K31/708 , A61K31/7068 , A61K31/7072 , A61P31/14 , A61K38/21 , A61P31/04 , A61P31/10 , A61P35/00 , A61P37/02 , C07H19/073
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/55 , A61K45/06 , A61K2300/00 , A61K31/426 , A61K31/13
摘要： The present invention relates to 2′-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-连烯取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。
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公开(公告)号：US09085599B2
公开(公告)日：2015-07-21
申请号：US13422268
申请日：2012-03-16
申请人： Yat Sun Or , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
发明人： Yat Sun Or , Jun Ma , Guoqiang Wang , In Jong Kim , Jiang Long , Yao-Ling Qiu
IPC分类号： A61K31/706 , C07H19/12 , C07H19/173 , C07H19/044 , C07H19/10 , C07H19/11 , C07H19/06 , A61K38/55 , A61K45/06 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K38/55 , A61K45/06 , A61K2300/00 , A61K31/426 , A61K31/13
摘要： The present invention relates to 2′-allene-substituted nucleoside derivatives of the general formula (I): As well as pharmaceutical compositions comprising such compounds and methods to treat or prevent an HIV infection, HBV infection, HCV infection or abnormal cellular proliferation, comprising administering said compounds or compositions. In addition, the present invention includes processes for the preparation of such compounds, and the related β-D and β-L-nucleoside derivatives.
摘要翻译： 本发明涉及通式（I）的2'-连烯取代的核苷衍生物：以及包含这些化合物的药物组合物以及治疗或预防HIV感染，HBV感染，HCV感染或异常细胞增殖的方法，包括 给药所述化合物或组合物。 此外，本发明包括制备这些化合物的方法，以及相关的β-和β-半胱氨酸衍生物。
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公开(公告)号：US08481483B2
公开(公告)日：2013-07-09
申请号：US12708671
申请日：2010-02-19
申请人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
发明人： Yat Sun Or , Guoqiang Wang , Xuri Gao , Jiang Long
摘要： The present invention provides cyclosporin analogues of formula I, and compositions comprising these compounds, as well as processes for their preparation, intermediates in their synthesis, and methods of use thereof for prevention of organ transplantation rejection, the treatment of immune disorders and inflammation, and treatment of viral (particularly hepatitis C viral) infection.
摘要翻译： 本发明提供式I的环孢菌素类似物，以及包含这些化合物的组合物，以及其制备方法，其合成中的中间体及其用于预防器官移植排斥反应，免疫疾病和炎症的治疗的方法和 治疗病毒（特别是丙型肝炎病毒）感染。
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公开(公告)号：US20110008286A1
公开(公告)日：2011-01-13
申请号：US12832383
申请日：2010-07-08
申请人： Guoqiang Wang , Yat Sun Or , Jiang Long , Xuri Gao
发明人： Guoqiang Wang , Yat Sun Or , Jiang Long , Xuri Gao
IPC分类号： A61K38/21 , C07K7/64 , A61K38/12 , A61P31/12 , A61P37/06 , A61P19/02 , A61P29/00 , A61P17/06 , A61P11/06
CPC分类号： C07K7/645 , A61K38/00 , Y02A50/463
摘要： The present invention provides novel proline substituted cyclosporinanalogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections.
摘要翻译： 本发明提供了新的脯氨酸取代的环孢菌素化合物，包含这些化合物的药物组合物和使用这些化合物治疗疾病和疾病，包括免疫疾病，炎症性疾病和病毒感染的方法。
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公开(公告)号：US20090264380A1
公开(公告)日：2009-10-22
申请号：US12399801
申请日：2009-03-06
申请人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
发明人： In Jong Kim , Tongzhu Liu , Jiang Long , Guoqiang Wang , Yao-Ling Qiu , Heejin Kim , Yanchun Wang , Ly Tam Phan , Yat Sun Or
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/04 , A61P29/00
CPC分类号： C07D493/08 , C07F9/65586 , C07H17/08
摘要： The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.
摘要翻译： 本发明公开了式I，II或X的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。
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公开(公告)号：US08685917B2
公开(公告)日：2014-04-01
申请号：US12832316
申请日：2010-07-08
申请人： Xuri Gao , Yat Sun Or , Guoqiang Wang , Jiang Long
发明人： Xuri Gao , Yat Sun Or , Guoqiang Wang , Jiang Long
CPC分类号： C07K7/645
摘要： The present invention provides novel cyclosporin analogue compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds for the treatment of disorders and diseases, including immune disorders, inflammatory disorders and viral infections.
摘要翻译： 本发明提供新的环孢菌素类似物化合物，包含这些化合物的药物组合物和使用这些化合物治疗疾病和疾病（包括免疫疾病，炎性疾病和病毒感染）的方法。
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公开(公告)号：US08367618B2
公开(公告)日：2013-02-05
申请号：US12697215
申请日：2010-01-30
申请人： Yat Sun Or , Guoqiang Wang , Jiang Long , Xuri Gao
发明人： Yat Sun Or , Guoqiang Wang , Jiang Long , Xuri Gao
IPC分类号： A61K38/13
CPC分类号： A61K38/13 , A61K31/7088 , A61K38/21 , A61K45/00 , A61K45/06 , C07K7/52 , C07K7/645 , Y02A50/463
摘要： The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
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10.发明申请公开(公告)号：US20100196316A1
公开(公告)日：2010-08-05
申请号：US12697215
申请日：2010-01-30
申请人： Yat Sun Or , Guoqiang Wang , Jiang Long , Xuri Gao
发明人： Yat Sun Or , Guoqiang Wang , Jiang Long , Xuri Gao
IPC分类号： A61K38/21 , C07D245/00 , A61K31/5377 , A61K31/41 , A61K31/4427 , A61K31/541 , A61K31/497 , A61K31/7056 , A61K31/711 , A61P31/12 , A61P31/14
CPC分类号： A61K38/13 , A61K31/7088 , A61K38/21 , A61K45/00 , A61K45/06 , C07K7/52 , C07K7/645 , Y02A50/463
摘要： The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.
摘要翻译： 本发明涉及对HCV具有抗病毒活性的环孢菌素类似物，可用于治疗HCV感染。 更具体地，本发明涉及新的环孢菌素类似物化合物，含有这些化合物的组合物及其使用方法，以及制备这些化合物的方法。
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