公开(公告)号：US10857149B2

公开(公告)日：2020-12-08

申请号：US16020799

申请日：2018-06-27

Applicant: H. Lundbeck A/S

Inventor： Svend Treppendahl ,  Heidi Lopez de Diego

IPC: A61K31/495 ,  A61K9/08 ,  C07C59/08 ,  C07D295/096

Abstract: Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.

公开(公告)号：US20190210987A1

公开(公告)日：2019-07-11

申请号：US16294647

申请日：2019-03-06

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez de Diego ,  Kim Lasse Christensen ,  Rene Holm ,  Jens Kateb

IPC: C07D295/096 ,  C07D207/28

CPC classification number: C07D295/096 ,  C07D207/28

Abstract: The present invention provides vortioxetine pyroglutamate salt and pharmaceutical compositions comprising said salt

公开(公告)号：US20170360777A1

公开(公告)日：2017-12-21

申请号：US15674043

申请日：2017-08-10

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm

IPC: A61K31/495 ,  A61K9/14 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl)]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US09125908B2

公开(公告)日：2015-09-08

申请号：US14242510

申请日：2014-04-01

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Arne Mork ,  Tine Bryan Stensbol ,  Andre Faldt ,  Rene Holm ,  Heidi Lopez de Diego

IPC: A61K31/495 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。

公开(公告)号：US08969355B2

公开(公告)日：2015-03-03

申请号：US14480949

申请日：2014-09-09

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Rene Holm ,  Heidi Lopez de Diego

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: This disclosure relates to a method of treating a disease selected from the group consisting of affective disorders, depression, major depressive disorder, anxiety, general anxiety disorder, social anxiety disorder, obsessive compulsive disorder, panic disorder, and panic attacks. The method includes administering a therapeutically effective amount of Compound I or a pharmaceutically acceptable salt thereof to a patient in need thereof, in which Compound I is 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine.

Abstract translation: 本公开涉及治疗选自情感障碍，抑郁症，重度抑郁障碍，焦虑症，一般焦虑症，社会焦虑症，强迫症，惊恐障碍和惊恐发作的疾病的方法。 该方法包括向有需要的患者施用治疗有效量的化合物I或其药学上可接受的盐，其中化合物I是1- [2-（2,4-二甲基苯基硫烷基） - 苯基]哌嗪。

公开(公告)号：US11458134B2

公开(公告)日：2022-10-04

申请号：US16502677

申请日：2019-07-03

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm ,  Michael J. Mealy

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14 ,  A61P25/22

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20220024962A1

公开(公告)日：2022-01-27

申请号：US17392970

申请日：2021-08-03

Applicant: H. Lundbeck A/S

Inventor： Klaus Gjervig Jensen ,  Lisbet Kværnø ,  Morten Jørgensen ,  Martin Juhl ,  Heidi Lopez de Diego ,  Karin Fredholt ,  Frans Dennis Therkelsen ,  Tobias Gylling Frihed ,  Mikkel Fogh Jacobsen

IPC: C07H15/26

Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.

公开(公告)号：US11130775B2

公开(公告)日：2021-09-28

申请号：US16876908

申请日：2020-05-18

Applicant: H. Lundbeck A/S

Inventor： Klaus Gjervig Jensen ,  Lisbet Kværnø ,  Morten Jørgensen ,  Martin Juhl ,  Heidi Lopez de Diego ,  Karin Fredholt ,  Frans Dennis Therkelsen ,  Tobias Gylling Frihed ,  Mikkel Fog Jacobsen

IPC: C07H15/26

Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below. The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.

公开(公告)号：US09861630B1

公开(公告)日：2018-01-09

申请号：US15674043

申请日：2017-08-10

Applicant: H. Lundbeck A/S

Inventor： André Faldt ,  Heidi Lopez de Diego ,  Rene Holm

IPC: A61K31/495 ,  C07D295/096 ,  A61K9/14

CPC classification number: A61K31/495 ,  A61K9/14 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl)]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

公开(公告)号：US20170224677A1

公开(公告)日：2017-08-10

申请号：US15271543

申请日：2016-09-21

Applicant: H. Lundbeck A/S

Inventor： Svend Treppendahl ,  Heidi Lopez de Diego

IPC: A61K31/495

CPC classification number: A61K31/495 ,  A61K9/08 ,  C07C59/08 ,  C07D295/096

Abstract: Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.