公开(公告)号：US20160107189A1

公开(公告)日：2016-04-21

申请号：US14894397

申请日：2014-05-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eiji HASHIMOTO ,  Toshiyuki MATSUDO ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO

IPC: B05C15/00 ,  F24F3/16 ,  F24F3/14 ,  B05C21/00 ,  B05C3/00

CPC classification number: B05C15/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B05C3/00 ,  B05C21/00 ,  B05D3/0486 ,  B81B2201/055 ,  B81C99/0025 ,  F24F3/14 ,  F24F3/1603

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.

Abstract translation: 本发明提供一种用于制造治疗性微针的系统，其构造成通过用含有药物的涂布液涂布微针来调节用于制造治疗性微针的涂布室内的空气环境，该制造用微生物的制造系统包括空气压缩机， 配置为调节从空气压缩机供给的空气的湿度的湿度调节器，以及被配置为从供给到涂布室内部的空气中除去微生物的空气过滤器。

公开(公告)号：US20240269446A1

公开(公告)日：2024-08-15

申请号：US17766434

申请日：2020-09-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Shinpei NISHIMURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle sheet according to one embodiment includes: a sheet body having a main surface; and at least one microneedle formed on the sheet body and lying along the main surface. Each of the at least one microneedle has a base positioned on a first side of the sheet body and a tip oriented toward a second side of the sheet body that is opposite to the first side. A first portion of the sheet body is bent from the first side, whereby the microneedle positioned in the first portion is raised from the main surface and the raised microneedle is applied to skin.

公开(公告)号：US20190381300A1

公开(公告)日：2019-12-19

申请号：US16488450

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toru KOBAYASHI ,  Toshiyuki MATSUDO ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Tetsuji KUWAHARA

IPC: A61M37/00

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US20190015652A1

公开(公告)日：2019-01-17

申请号：US16134030

申请日：2018-09-18

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya KOMINAMI ,  Shinpei NISHIMURA ,  Seiji TOKUMOTO ,  Makoto OGURA ,  Toshiyuki MATSUDO ,  Naoki YAMAMOTO

IPC: A61M37/00 ,  A61N2/00 ,  A61N1/32

Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.