Highly water-soluble metalloproteinase inhibitors
    11.
    发明授权
    Highly water-soluble metalloproteinase inhibitors 失效
    高度水溶性金属蛋白酶抑制剂

    公开(公告)号:US6147114A

    公开(公告)日:2000-11-14

    申请号:US945356

    申请日:1997-10-24

    摘要: New compounds of the general formula (I) ##STR1## (wherein R.sup.1 is a hydrogen atom, or a hydroxyl, aryl (C.sub.1 -C.sub.6)alkylene or --A--SOn--B group (A is a (C.sub.1 -C.sub.6) alkylene group; B is a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) acyl, aryl or heterocyclyl group; n is 0, 1 or 2), R.sup.2 is a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkyloxy 10 or (C.sub.1 -C.sub.6) alkylthio group, R.sup.3 and R.sup.4 are identical or different, representing a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, aryl or aryl(C.sub.1 -C.sub.6)alkylene group, R.sup.5 is a --Y--C or C group (Y is a (C.sub.1 -C.sub.6) alkylene group, an oxygen atom, an imino group or a (C.sub.1 -C.sub.6) alkyleneimino group, C is a sulfonic acid, phosphonic acid, amidino, (C.sub.1 -C.sub.6) acyl, acylimidoyl, diphosphonomethine or dicarboxymethine group), and R.sup.6 is a hydrogen atom, or a nonsubstituted or substituted benzyl, trialkylsilyl, tert-butyldiphenylsilyl, tetrahydropyranyl or tert-butyl group) or stereoisomers thereof, and pharmaceutically acceptable salts thereof and solvates thereof, and the process for the preparation thereof, and metalloproteinase inhibitors which comprise one or more compounds selected from those compounds as effective ingredients and inhibit matrix metalloproteinases (MMPs) and/or TNF-.alpha. converting enzyme. Furthermore, the preparation intermediates to obtain the compounds of the formula (I) and the process for the preparation.

    摘要翻译: PCT No.PCT / JP96 / 01135 Sec。 371 1997年10月24日第 102(e)1997年10月24日PCT PCT 1996年4月25日PCT公布。 WO96 / 33968 PCT公开号 日期:1996年10月31日新化合物通式(Ⅰ)(其中R1是氢原子,或羟基,芳基(C1-C6)亚烷基或-A-SOn-B基团(A是(C1-C6) 亚烷基; B是(C1-C6)烷基,(C1-C6)酰基,芳基或杂环基; n是0,1或2),R2是氢原子或(C1-C6)烷基, C1-C6)烷氧基10或(C1-C6)烷硫基,R3和R4相同或不同,代表氢原子或(C1-C6)烷基,芳基或芳基(C1-C6)亚烷基,R5是 -YC或C基(Y是(C1-C6)亚烷基,氧原子,亚氨基或(C1-C6)亚烷基亚氨基),C是磺酸,膦酸,脒基,(C1-C6 )酰基,酰亚氨基,二亚膦酰基或二羧基甲基),R6为氢原子,或未取代或取代的苄基,三烷基甲硅烷基,叔丁基二苯基甲硅烷基,四氢吡喃基或叔丁基)或其立体异构体及其药学上可接受的盐及其溶剂合物 ,以及其准备过程 f和金属蛋白酶抑制剂,其包含一种或多种选自那些化合物的化合物作为有效成分并抑制基质金属蛋白酶(MMP)和/或TNF-α转化酶。 此外,制备中间体以获得式(I)化合物及其制备方法。

    Air conditioning apparatus having electric heating member integrated
with heating heat exchanger
    12.
    发明授权
    Air conditioning apparatus having electric heating member integrated with heating heat exchanger 失效
    具有与加热热交换器一体化的电加热构件的空调装置

    公开(公告)号:US06078024A

    公开(公告)日:2000-06-20

    申请号:US78048

    申请日:1998-05-13

    IPC分类号: B60H1/03 F28D1/053 B60H1/22

    CPC分类号: B60H1/2218 F28D1/05366

    摘要: An air conditioning apparatus includes a heating heat exchanger for heating air blown toward a passenger compartment using hot water as a heating source. A plurality of electric heating members are formed integrally with the heating heat exchanger, and electric power supplied to the electric heating members is controlled according a temperature of the hot water. Therefore, a number of the electric heating members to be operated is finely controlled according to the temperature of water flowing through the heating heat exchanger. Further, when a water temperature of the heating heat exchanger is lower than a predetermined temperature (e.g., 35.degree. C.), a water valve is closed to interrupt the flow of water to the heating heat exchanger, and a blower is operated. Therefore, a quantity of heat transmitted from the electric heating members to the water in the heating heat exchanger can be greatly decreased.

    摘要翻译: 一种空气调节装置,其特征在于,包括:加热用热交换器,其使用热水作为加热源加热向乘客室吹出的空气。 多个电加热构件与加热热交换器一体地形成,并且根据热水的温度来控制供应到电加热构件的电力。 因此,根据流过加热热交换器的水的温度,精细地控制多个要操作的电加热构件。 此外,当加热热交换器的水温低于预定温度(例如35℃)时,关闭水阀以中断向加热热交换器的水流,并且操作鼓风机。 因此,能够大幅度减少从加热用热交换器中的电加热构件传递给水的热量。

    Auxiliary heat source apparatus for vehicle and heating apparatus
employing the same
    13.
    发明授权
    Auxiliary heat source apparatus for vehicle and heating apparatus employing the same 失效
    用于车辆的辅助热源装置和采用该辅助热源装置

    公开(公告)号:US5778843A

    公开(公告)日:1998-07-14

    申请号:US933295

    申请日:1997-09-18

    IPC分类号: F24J3/00 F02N17/02 F27B3/06

    CPC分类号: F24J3/003

    摘要: According to the present invention, an oil storage chamber for temporarily accumulating a high-viscosity oil is formed below a heat-generating chamber for accumulating high-viscosity oil which generates heat when a shearing force is applied thereto. When an electromagnetic coil of an electromagnetic clutch is set off, i.e., a rotation of a rotor of a viscous heater is stopped, the high-viscosity oil in the heat-generating chamber moves into the oil storage chamber by own weight thereof, and a liquid level of the high-viscosity oil in the heat-generating chamber is greatly reduced. In this way, when the electromagnetic coil of the electromagnetic clutch is turned on to start the rotor of the viscous heater, a torque applied to the rotor is greatly reduced, with the result that a stress applied to the rotor is reduced.

    摘要翻译: 根据本发明,在用于积聚在施加剪切力时产生热量的高粘度油的发热室下形成用于临时积聚高粘度油的储油室。 当离开电磁离合器的电磁线圈即停止粘性加热器的转子旋转时,发热室中的高粘度油通过其自身的重量移动到储油室中,并且 发热室中高粘度油的液位大大降低。 以这种方式,当电磁离合器的电磁线圈接通以启动粘性加热器的转子时,施加到转子的扭矩大大降低,结果施加到转子上的应力减小。

    Resistor circuit with reduced temperature coefficient of resistance
    14.
    发明授权
    Resistor circuit with reduced temperature coefficient of resistance 失效
    电阻电路具有降低的电阻温度系数

    公开(公告)号:US5254938A

    公开(公告)日:1993-10-19

    申请号:US871345

    申请日:1992-04-21

    申请人: Hajime Ito

    发明人: Hajime Ito

    CPC分类号: G05F1/56 H01C7/008

    摘要: A resistor circuit which includes a pair of linear conductive films and a resistive film. The resistive film is formed on an area between the conductive films and electrically connected to the conductive films. A pair of terminals are electrically connected to portions of the conductive films respectively. A current source is electrically connected between the terminals to flow an electric current between the terminals. A pair of voltage output terminals are electrically connected to portions of the conductive films respectively. At least one of the voltage output terminals is disposed at a position other than a position in which the terminals are formed. An output voltage output from the voltage output terminals is exactly proportional to a current flowing between them without an influence of change of an ambient temperature.

    摘要翻译: 一种包括一对线性导电膜和电阻膜的电阻电路。 电阻膜形成在导电膜之间并与导电膜电连接的区域上。 一对端子分别电连接到导电膜的一部分。 电流源电连接在端子之间以在端子之间流过电流。 一对电压输出端子分别与导电膜的部分电连接。 电压输出端子中的至少一个设置在除端子形成位置以外的位置。 从电压输出端子输出的输出电压与其间流过的电流成正比,而不受环境温度变化的影响。

    Ozone generator
    15.
    发明授权
    Ozone generator 失效
    臭氧发生器

    公开(公告)号:US4725412A

    公开(公告)日:1988-02-16

    申请号:US868328

    申请日:1986-05-27

    申请人: Hajime Ito

    发明人: Hajime Ito

    IPC分类号: C01B13/10 C01B13/11

    摘要: An ozone generator has a construction in which: an outer and an inner sleeves made of fused quartz or ordinary glass are mounted inside a casing of the generator, which sleeves are substantially concentrically arranged to form an air gap therebetween, while conducting films are formed on the outer periphery of the outer sleeve and the inner periphery of the inner sleeve to provide opposite discharge electrodes an inner one of which is grounded and an outer one of which is connected to high voltage side of an electric source, to which air gap a raw gas is fed while electrical discharge is conducted between these electrodes to produce ozonized gas from the raw gas.

    摘要翻译: 臭氧发生器具有这样的结构,其中:由熔融石英或普通玻璃制成的外套筒和内套筒安装在发生器的壳体内,该套筒基本上同心地布置以在它们之间形成气隙,同时在 外套筒的外周和内套筒的内周,以提供相反的放电电极,其内部的一个接地,外部的一个连接到电源的高压侧,空隙为原料 在这些电极之间进行放电的同时供给气体,从原料气体产生臭氧化气体。

    Latent heat accumulating greenhouse
    16.
    发明授权
    Latent heat accumulating greenhouse 失效
    潜热蓄热温室

    公开(公告)号:US4510921A

    公开(公告)日:1985-04-16

    申请号:US416358

    申请日:1982-09-10

    CPC分类号: F24J2/34 Y02B10/20 Y02E10/40

    摘要: This invention relates to a latent heat accumulating greenhouse utilizing solar heat. The object of the invention is to provide a greenhouse which is simple in construction, of high efficiency for heat absorbing and capable of much absorbing and accumulating of heat. A heat accumulating chamber (B) partitioned by transparent sheets (1) is provided between the attic and a floor surface facing north in the greenhouse (A). A blower fan (2) is disposed to confront an opening (1a) provided at the lower portion in said heat accumulating chamber (B). Also, in the heat accumulating chamber (B), a heat accumulating unit (3) having a large number of light transmitting windows (32) and enclosing a phase transformation heat accumulating material (33) such as CaCl.sub.2.6H.sub.2 O, Na.sub.2 SO.sub.4.10H.sub.2 O therein is detachably suspended in a position close to windowpanes at the north side.

    摘要翻译: PCT No.PCT / JP82 / 00064 Sec。 371日期1982年9月10日 102(e)1982年9月10日PCT PCT日期为1982年3月8日。本发明涉及利用太阳热的潜热蓄热温室。 本发明的目的是提供一种结构简单,效率高,吸热能力高的温室。 在阁楼和温室(A)北面的地板表面之间设置由透明片(1)分隔的蓄热室(B)。 鼓风扇(2)设置成面对设置在所述蓄热室(B)的下部的开口(1a)。 此外,在蓄热室(B)中,具有大量透光窗(32)并且包围相变相蓄热材料(33)的蓄热单元(3),其中包含CaCl 2·6H 2 O,Na 2 SO 4·10H 2 O, 可拆卸地悬挂在靠近北侧的窗玻璃的位置。

    Automotive rear safety checking apparatus
    17.
    发明授权
    Automotive rear safety checking apparatus 失效
    汽车后部安全检查装置

    公开(公告)号:US4467313A

    公开(公告)日:1984-08-21

    申请号:US320568

    申请日:1981-11-12

    IPC分类号: G08G1/16 G08G1/00 G08B13/16

    CPC分类号: G08G1/16 Y10S367/909

    摘要: An automotive rear safety checking apparatus which comprises a plurality of obstacle detectors mounted on the rear part of the automobile for radiating ultrasonic wave on the watching areas smaller in width than the width of the automobile respectively and detecting the ultrasonic wave reflected from an obstacle. The ultrasonic wave is radiated from the obstacle detectors in time division. Pulse signals in the number associated with the distance between the obstacle detector and the obstacle are generated in response to the detection of the ultrasonic wave reflected from the obstacle, so that the relative positions of the automobile and the obstacle, are indicated two-dimensionally in accordance with the pulse signal.

    摘要翻译: 一种汽车后部安全检查装置,其包括安装在汽车后部的多个障碍物检测器,用于在比汽车宽度小的观察区域上散发超声波,并且检测从障碍物反射的超声波。 超声波从障碍物检测器以时分方式辐射。 响应于从障碍物反射的超声波的检测,生成与障碍物检测器和障碍物之间的距离相关联的数字中的脉冲信号,使得汽车和障碍物的相对位置被二维地指示 符合脉冲信号。

    Rotary type hydraulic servo-mechanism
    18.
    发明授权
    Rotary type hydraulic servo-mechanism 失效
    旋转式液压伺服机构

    公开(公告)号:US3939756A

    公开(公告)日:1976-02-24

    申请号:US503518

    申请日:1974-09-05

    IPC分类号: F15B15/12 B62D5/14 F15B9/10

    CPC分类号: F15B9/10 B62D5/14

    摘要: A rotary type hydraulic servo-mechanism constructed with a hollow-cylindrical casing, an input shaft extending through the casing, a driven output member slidably mounted on the casing, a servo-valve mechanism formed in the surface of the input shaft which slides on the driven output member, a hydraulic fluid chamber to generate a resisting torque against rotational force of the input shaft, and a passage to connect this hydraulic fluid chamber with the servo-valve mechanism, and hydraulic drive chambers defined by a space between the inner wall of the hollow cylindrical casing and the outer periphery of the driven output member.

    摘要翻译: 一种由中空圆柱形壳体构成的旋转式液压伺服机构,通过壳体延伸的输入轴,可滑动地安装在壳体上的从动输出构件,形成在输入轴表面上的伺服阀机构,其在 驱动输出构件,液压流体室,以产生抵抗输入轴的旋转力的阻力矩;以及将该液压流体室与伺服阀机构连接的通道,以及液压驱动室,其由 中空圆柱形壳体和从动输出构件的外周。

    ADAMANTANE DERIVATIVE, EPOXY RESIN, AND OPTICAL ELECTRONIC MEMBER USING RESIN COMPOSITION COMPRISING THEM
    20.
    发明申请
    ADAMANTANE DERIVATIVE, EPOXY RESIN, AND OPTICAL ELECTRONIC MEMBER USING RESIN COMPOSITION COMPRISING THEM 审中-公开
    ADAMANTANE衍生物,环氧树脂和使用包含它们的树脂组合物的光电子成员

    公开(公告)号:US20090137775A1

    公开(公告)日:2009-05-28

    申请号:US12065651

    申请日:2006-08-31

    申请人: Hajime Ito

    发明人: Hajime Ito

    摘要: This invention provides an adamantane derivative that can provide a cured product having excellent optical properties such as transparency and lightfastness, long-term heat resistance, and electric characteristics such as permittivity, and an epoxy resin having an adamantane skeleton, a resin composition comprising them, and an optical electronic member using the resin composition. The adamantane derivative is represented by general formula (I). The epoxy resin having an adamantane skeleton is represented by general formula (V) or (VI). The resin composition comprises them. The optical electronic member uses the resin composition. In the formula, W represents, for example, a hydrogen atom, X represents a group represented by general formula (II), Y represents, for example, —O—, Z represents a group represented by formula (III) or (IV), R1 represents a methyl or ethyl group, R2 represents an alkyl group having 1 to 4 carbon atoms, k is an integer of 0 to 10, m is an integer of 0 to 14, n is an integer of 2 to 16, m+n=16, and p and q are an integer of 0 to 5.

    摘要翻译: 本发明提供一种金刚烷衍生物,其可以提供具有优异的光学性能如透明性和耐光性,长期耐热性和电特性如介电常数的固化产物,以及具有金刚烷骨架的环氧树脂,包含它们的树脂组合物, 以及使用该树脂组合物的光电子部件。 金刚烷衍生物由通式(I)表示。 具有金刚烷骨架的环氧树脂由通式(V)或(VI)表示。 树脂组合物包含它们。 光电子部件使用树脂组合物。 在该式中,W表示例如氢原子,X表示通式(II)表示的基团,Y表示例如-O-,Z表示由式(III)或(IV)表示的基团, R 1表示甲基或乙基,R 2表示碳原子数1〜4的烷基,k表示0〜10的整数,m表示0〜14的整数,n表示2〜16的整数,m + n = 16,p和q为0〜5的整数。