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11.发明授权Use of cyclopentabenzofuran-derivatives for combating (NF-&kgr;B)-dependent diseases 失效使用环戊苯并呋喃衍生物对抗（NF-κB）依赖性疾病公开(公告)号：US06518274B1
公开(公告)日：2003-02-11
申请号：US09762448
申请日：2001-04-18
申请人： Matthias Gehling , Jörg Baumgarten , Axel Kretschmer , Horst-Peter Antonicek , Peter Proksch , Bambang Wahyu Nugroho , Frank Bohnenstengel
发明人： Matthias Gehling , Jörg Baumgarten , Axel Kretschmer , Horst-Peter Antonicek , Peter Proksch , Bambang Wahyu Nugroho , Frank Bohnenstengel
IPC分类号： A61P910
CPC分类号： A61K31/343 , Y10S514/824 , Y10S514/825 , Y10S514/826 , Y10S514/885 , Y10S514/886 , Y10S514/908
摘要： The invention relates to the use of cycloventabenzofuran derivatives for the production of a medicament for the treatment of nuclear factor of &kgr;B-dependent diseases.
摘要翻译： 本发明涉及环烷基苯并呋喃衍生物在制备用于治疗κB依赖性疾病的核因子的药物中的用途。
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公开(公告)号：US5955571A
公开(公告)日：1999-09-21
申请号：US509913
申请日：1995-08-01
申请人： Christoph Schwemler , Thorsten Potter , Burkhard Mielke , Eckhard Schwenner , Axel Kretschmer , Udo Stropp , Winfried Kosch , Hansjorg Durr
发明人： Christoph Schwemler , Thorsten Potter , Burkhard Mielke , Eckhard Schwenner , Axel Kretschmer , Udo Stropp , Winfried Kosch , Hansjorg Durr
CPC分类号： C07K14/003 , A61K38/00
摘要： The present invention relates to compounds of the general formula (I), ##STR1## in which the radicals have the meaning given in the description, to processes for their preparation and to their use as medicaments.
摘要翻译： 本发明涉及通式（I）的化合物，其中基团具有说明书中给出的含义，其制备方法及其作为药物的用途。
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公开(公告)号：US5583035A
公开(公告)日：1996-12-10
申请号：US338355
申请日：1994-11-14
申请人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
发明人： Axel Kretschmer , Horst-Peter Antonicek , Jorg Baumgarten , Antonius Loebberding , Burkhard Mielke , Wolfgang Springer , Udo Stropp , Mark-Michael Struck , Lothar Biesert , Helga Rubsamen-Waigmann , Hary Suhartono , Thomas-Peter Hausner
IPC分类号： C12N15/113 , C12H5/22 , C12H15/85
CPC分类号： C12N15/1132 , C12N2310/111 , C12N2799/021
摘要： The present invention relates to the targeted blocking of the genetic information of the viral messenger ribonucleic acid (mRNA) for virus replication (e.g. of HIV) in transfected, haematopoietic cells with particularly suitable expression systems, which express a complementary "antisense RNA".
摘要翻译： 本发明涉及具有表达互补的“反义RNA”的特别合适的表达系统的转染的造血细胞中用于病毒复制的病毒信使核糖核酸（mRNA）的遗传信息的靶向阻断。
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公开(公告)号：US20130231313A1
公开(公告)日：2013-09-05
申请号：US13819885
申请日：2011-09-14
申请人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , C07D409/04 , A61K45/06 , C07D249/12
CPC分类号： A61K31/4196 , A61K45/06 , C07D249/12 , C07D409/04
摘要： The present application relates to novel substituted phenylacetamides and phenylpropanamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的苯乙酰胺和苯丙酰胺，用于制备它们的方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防的药物的用途 的疾病，更特别地用于治疗和/或预防心血管疾病。
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公开(公告)号：US08487020B2
公开(公告)日：2013-07-16
申请号：US13379367
申请日：2010-06-28
申请人： Fabrizio Galeone , Axel Kretschmer , Leon Marteaux , Jean-Thierry Simonnet , Brett Lee Zimmerman
发明人： Fabrizio Galeone , Axel Kretschmer , Leon Marteaux , Jean-Thierry Simonnet , Brett Lee Zimmerman
CPC分类号： C08J3/03 , B01J13/14 , C08G77/12 , C08G77/20 , C08J2383/04 , C08L83/02 , C08L83/04 , C09D183/04 , D21H13/00 , D21H19/32 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , C08L83/00
摘要： Aqueous suspensions of silicate shell microcapsules are disclosed wherein a first portion of the silicate shell micro-capsules contain an organopolysiloxane having at least two alkenyl groups and a hydrosilylation catalyst as Part A of a curable siloxane composition, and a second portion of the silicate shell microcapsules contain an organohydrogensiloxane as Part B of the curable siloxane composition.
摘要翻译： 公开了硅酸盐壳微胶囊的水性悬浮液，其中硅酸盐壳微胶囊的第一部分含有具有至少两个烯基的有机聚硅氧烷和作为可固化硅氧烷组合物的部分A的氢化硅烷化催化剂，并且硅酸盐壳微胶囊的第二部分 含有有机氢硅氧烷作为可固化硅氧烷组合物的B部分。
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16.发明申请TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY 审中-公开三唑衍生物作为治疗心脏不足的血管收缩素抑制剂公开(公告)号：US20120053218A1
公开(公告)日：2012-03-01
申请号：US13255515
申请日：2010-03-09
申请人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiß , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Ulf Brüggemeier , Chantal Fürstner , Volker Geiß , Joerg Keldenich , Armin Kern , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , A61P7/10 , A61P1/00 , A61P7/00 , A61P1/16 , C07D249/12 , A61P9/04
CPC分类号： C07D249/12
摘要： The present application relates to novel substituted phenylalanine derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的苯丙氨酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产药物用于治疗和/或预防 疾病，更特别地用于治疗和/或预防心血管疾病。
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公开(公告)号：US20100298221A1
公开(公告)日：2010-11-25
申请号：US12440725
申请日：2007-08-30
申请人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
发明人： Heinrich Meier , Peter kolkhof , Axel Kretschmer , Arounarith Tuch , Lars Barfacker , Yolanda Cancho Grande
IPC分类号： A61K38/16 , C07D213/80 , C07D213/22 , A61K31/444 , A61K31/4412 , A61K31/546 , A61K31/585 , A61K31/55 , A61K31/551 , A61K31/60 , A61K31/4365 , A61K31/519 , A61P3/00 , A61P9/10 , A61P9/00
CPC分类号： C07D213/80
摘要： The present invention relates to novel 2-phenoxy-6-phenyl- and 2-phenoxy-6-pyridylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, especially of dyslipidemias, arteriosclerosis and heart failure.
摘要翻译： 本发明涉及新的2-苯氧基-6-苯基 - 和2-苯氧基-6-吡啶基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。
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公开(公告)号：US06420393B1
公开(公告)日：2002-07-16
申请号：US09762417
申请日：2001-03-26
申请人： Walter Guarnieri , Thomas Jaetsch , Andreas Schoop , Jörg Baumgarten , Axel Kretschmer , Horst-Peter Antonicek
发明人： Walter Guarnieri , Thomas Jaetsch , Andreas Schoop , Jörg Baumgarten , Axel Kretschmer , Horst-Peter Antonicek
IPC分类号： A61K31443
CPC分类号： C07D307/93
摘要： The invention relates to cyclopentabenzofuran derivatives, processes for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-&kgr;B-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.
摘要翻译： 本发明涉及环戊烷并苯并呋喃衍生物，其制备方法，使用环戊二酸苯并呋喃衍生物用于制备用于治疗NF-κB依赖性疾病的药物和含有环戊二酸苯并呋喃衍生物的药物。
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公开(公告)号：US09180120B2
公开(公告)日：2015-11-10
申请号：US13818337
申请日：2011-08-31
申请人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/41 , A61K31/4196 , C07D249/12 , C07D409/04 , A61K45/06
CPC分类号： A61K31/4196 , A61K45/06 , C07D249/12 , C07D409/04
摘要： The present application relates to novel substituted N-phenethyltriazoloneacetamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的N-苯乙基三唑酮乙酰胺，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和/或预防的药物的用途 的疾病，更特别地用于治疗和/或预防心血管疾病。
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公开(公告)号：US20130225646A1
公开(公告)日：2013-08-29
申请号：US13818337
申请日：2011-08-31
申请人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
发明人： Chantal Fürstner , Joerg Keldenich , Martina Delbeck , Peter Kolkhof , Axel Kretschmer , Elisabeth Pook , Carsten Schmeck , Hubert Trübel
IPC分类号： A61K31/4196 , C07D409/04 , A61K45/06 , C07D249/12
CPC分类号： A61K31/4196 , A61K45/06 , C07D249/12 , C07D409/04
摘要： The present application relates to novel substituted N-phenethyltriazoloneacetamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的N-苯乙基三唑酮乙酰胺，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和/或预防的药物的用途 的疾病，更特别地用于治疗和/或预防心血管疾病。
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