公开(公告)号：US20100267823A1

公开(公告)日：2010-10-21

申请号：US12749060

申请日：2010-03-29

Applicant: Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

Inventor： Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

IPC: A61K31/343 ,  C07D307/83 ,  A61P25/00 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18

CPC classification number: C07D307/83 ,  C07D407/04

Abstract: The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with a phosphodiesterase (PDE) dependent disease or condition of the central nervous system, as well as methods, uses and other inventions related thereto.

Abstract translation: 本发明涉及包含它们可用于预防和/或治疗具有磷酸二酯酶（PDE）依赖性疾病或中枢神经系统病症的动物（包括人）以及方法，用途和其它 与此相关的发明。

公开(公告)号：US5728179A

公开(公告)日：1998-03-17

申请号：US560567

申请日：1995-11-20

Applicant: Matthias Gehling ,  Josef Pfeiffer ,  Rainer Tostmann ,  Nicolai Wickert

Inventor： Matthias Gehling ,  Josef Pfeiffer ,  Rainer Tostmann ,  Nicolai Wickert

IPC: C11D1/38 ,  C11D3/37 ,  C11D3/43 ,  D06L1/04 ,  D06L1/06 ,  D06L1/12 ,  D06L1/14 ,  D06L1/00

CPC classification number: D06L1/14

Abstract: A process for removing finishing agents containing silicone oil from textile substrates in an aqueous medium free of halogenated hydrocarbons, wherein the removing agent is a composition containing, as an essential ingredient, a surfactant carrying cationic groups on the surfactant framework structure, and which may also contain acids, non-ionic surfactants, water-soluble non-ionic polymers and solvents (free of halogenated hydrocarbons).

Abstract translation: 一种在不含卤代烃的水性介质中从纺织品底物除去含有硅油的整理剂的方法，其中除去剂是含有作为必需成分的表面活性剂骨架结构上带有阳离子基团的表面活性剂的组合物， 含有酸，非离子表面活性剂，水溶性非离子聚合物和溶剂（不含卤代烃）。

公开(公告)号：US20150050371A1

公开(公告)日：2015-02-19

申请号：US14382237

申请日：2012-03-09

Applicant: Matthias Gehling ,  Bärbel Köpcke ,  Thomas Küper ,  Kathrin Reinhardt ,  Peter Reinemer ,  Annie George ,  Sasikala Chinnappan ,  Mazria Haslina Md Akir

Inventor： Matthias Gehling ,  Bärbel Köpcke ,  Thomas Küper ,  Kathrin Reinhardt ,  Peter Reinemer ,  Annie George ,  Sasikala Chinnappan ,  Mazria Haslina Md Akir

IPC: A61K36/61 ,  A23L1/30 ,  A61K45/06

CPC classification number: A61K36/61 ,  A23L33/105 ,  A23V2002/00 ,  A61K45/06 ,  A61K2236/33

Abstract: The present invention primarily relates to the use of certain extract formulations of Rhodamnia cinerea as defined herein as alpha-amylase inhibitors and as actives for the therapeutic (including prophylactic) treatment of a carbohydrate metabolic disorder or of a disease attendant on hyperglycemia, preferably selected from the group consisting of prediabetes, obesity, hyperlipemia, arteriosclerosis, arteriolosclerosis, atherosclerosis, diabetes, postprandial hyperglycemia, and metabolic syndrome. The present invention also relates to corresponding methods. The invention further relates to specific extract formulations obtainable from Rhodamnia cinerea and to compositions, in particular orally consumable compositions, comprising an effective amount of such an extract formulation.

Abstract translation: 本发明主要涉及本文定义的灰葡萄糖苷的某些提取物制剂在α-淀粉酶抑制剂中的用途，以及用于治疗（包括预防）治疗碳水化合物代谢紊乱或伴随高血糖症的疾病的活性物质，优选选自 由糖尿病前期，肥胖，高脂血症，动脉硬化，动脉硬化，动脉粥样硬化，糖尿病，餐后高血糖症和代谢综合征组成的组。 本发明还涉及相应的方法。 本发明还涉及可从灰葡萄球菌获得的特定提取物制剂以及包含有效量的这种提取物制剂的组合物，特别是口服消耗品组合物。

公开(公告)号：US20120245113A1

公开(公告)日：2012-09-27

申请号：US13402675

申请日：2012-02-22

Applicant: Matthias GEHLING ,  Torsten GROTHE ,  Ernst ROEMER ,  Peter REINEMER ,  Kathrin REINHARDT ,  Annie GEORGE ,  Nur Hanisah MOHTAR ,  Noorsyarida Mohd Sapiai

Inventor： Matthias GEHLING ,  Torsten GROTHE ,  Ernst ROEMER ,  Peter REINEMER ,  Kathrin REINHARDT ,  Annie GEORGE ,  Nur Hanisah MOHTAR ,  Noorsyarida Mohd Sapiai

IPC: A61K31/7048 ,  A61P29/00 ,  A61P37/08 ,  A61P11/00 ,  A61P27/02 ,  A61P17/06 ,  A61P17/00 ,  A61P1/00 ,  A61P19/08 ,  A61P19/02 ,  A61P21/00 ,  A61P13/10 ,  C07D407/08 ,  C07D407/04 ,  A61K31/365 ,  A61K31/366 ,  C07H15/26

CPC classification number: C07D407/08 ,  C07D407/04 ,  C07H17/08

Abstract: The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.

Abstract translation: 使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物 包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

公开(公告)号：US20120040956A1

公开(公告)日：2012-02-16

申请号：US13152365

申请日：2011-06-03

Applicant: Philipp WABNITZ ,  Matthias Gehling ,  Thomas Henkel ,  M. Lienhard Schmitz

Inventor： Philipp WABNITZ ,  Matthias Gehling ,  Thomas Henkel ,  M. Lienhard Schmitz

IPC: A61K31/343 ,  A61P7/00 ,  A61P13/00 ,  A61P15/00 ,  A61P1/00 ,  A61P17/02 ,  A61P15/02 ,  A61P27/02 ,  A61P27/06 ,  A61P11/00 ,  A61P9/12 ,  A61P13/12 ,  A61P19/02 ,  A61P29/00 ,  A61K31/4025

CPC classification number: A61K31/343 ,  C07D307/93

Abstract: The invention relates to cyclopentabenzofuran derivatives for the treatment and/or prophylaxis of angiogenesis-related disorders.

Abstract translation: 本发明涉及用于治疗和/或预防血管发生相关疾病的环戊烷并苯并呋喃衍生物。

公开(公告)号：US5607482A

公开(公告)日：1997-03-04

申请号：US525109

申请日：1995-09-08

Applicant: Helmut Reiff ,  Herbert Wigger ,  Matthias Gehling ,  Karl-Heinz Passon

Inventor： Helmut Reiff ,  Herbert Wigger ,  Matthias Gehling ,  Karl-Heinz Passon

IPC: C08G18/08 ,  C08G18/10 ,  C08G18/28 ,  C08G18/48 ,  C08G18/80 ,  D06P1/52 ,  D06P1/54

CPC classification number: D06P1/54 ,  C08G18/0804 ,  C08G18/283 ,  C08G18/8061 ,  C08G18/8064 ,  C08G18/8077 ,  D06P1/5285

Abstract: The present invention relates to a method for textile printing with aqueous dispersions in which an organic fixing agent is crosslinked with a blocked polyisocyanate having (i) an average molecular weight of about 800 to about 25,000, (ii) a content of blocked isocyanate groups, calculated as free NCO and based on non-blocked polyisocyanate, corresponding to an NCO content of about 5 to about 20% by weight, (iii) an ionic group content of about 1 to about 75 milliequivalents per 100 g of blocked polyisocyanate, and (iv) a content of polyalkylene oxide units of about 1 to about 20% by weight, based on blocked polyisocyanate, said blocked polyisocyanate being obtained by the reaction of(a) organic polyisocyanates,(b) isocyanate-reactive compounds containing (potential) ionic groups,(c) polyalkylene ether alcohols,(d) NCO blocking agents, and(e) optionally, isocyanate-reactive compounds that are different from components (b), (c), and (d).

Abstract translation: 本发明涉及用水分散体进行纺织印花的方法，其中有机固定剂与封端多异氰酸酯交联，所述封端多异氰酸酯的平均分子量为约800至约25,000，（ii）封端异氰酸酯基的含量， 计算为游离NCO并基于非封端多异氰酸酯，对应于约5至约20重量％的NCO含量，（iii）离子基团含量为约1至约75毫当量/ 100g封端多异氰酸酯，和（ iv）基于封端多异氰酸酯的约1至约20重量％的聚环氧烷单元的含量，所述封端多异氰酸酯是通过（a）有机多异氰酸酯反应获得的，（b）含有（电位）离子的异氰酸酯反应性化合物 （c）聚亚烷基醚醇，（d）NCO封闭剂，和（e）任选的不同于组分（b），（c）和（d）的异氰酸酯反应性化合物。

公开(公告)号：US20110151033A1

公开(公告)日：2011-06-23

申请号：US12973056

申请日：2010-12-20

Applicant: Matthias GEHLING ,  Torsten GROTHE ,  Joachim HANS ,  Philipp W. WABNITZ ,  Tengku Shahrir TENGKU ADNAN

Inventor： Matthias GEHLING ,  Torsten GROTHE ,  Joachim HANS ,  Philipp W. WABNITZ ,  Tengku Shahrir TENGKU ADNAN

IPC: A61K36/53 ,  A61K31/235 ,  A61P25/00 ,  A61P25/24 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30

CPC classification number: A61K36/53 ,  A61K31/235

Abstract: The present invention relates to the use of compounds of isopimarane diterpene type, e.g. obtainable as or from extracts from Orthosiphon species, especially certain enriched or purified specific compounds therefrom, as well as said compounds or extracts for use or methods of using said compounds or extracts in the management of cognitive performance; in mammals, especially humans, respectively.The isopimarane diterpene type compounds can be of the formula wherein the symbols are as defined in the description and claims.

Abstract translation: 本发明涉及异戊二烯二萜类化合物的用途，例如， 可从Orthosiphon物种的提取物获得，特别是其中一些富集或纯化的特异性化合物，以及用于使用的所述化合物或提取物或使用所述化合物或提取物来管理认知表现的方法; 分别在哺乳动物，特别是人类。 异戊二烯二萜类化合物可以具有下式，其中符号如说明书和权利要求书中所定义。

公开(公告)号：US20100267822A1

公开(公告)日：2010-10-21

申请号：US12749024

申请日：2010-03-29

Applicant: Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joachim Hans ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

Inventor： Annie George D/O V.K. George ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Joachim Hans ,  Joerg Gruenwald ,  Matthias Gehling ,  Philipp Wabnitz ,  Tengku Shahrir bin Tengku Adnan ,  Torsten Grothe

IPC: A61K31/343 ,  C07D307/83 ,  A61P25/00 ,  A61P25/24 ,  A61P25/28 ,  A61P27/02 ,  A61P9/12 ,  A61P19/08 ,  A61P35/00 ,  A61P9/00 ,  A61P15/00 ,  A61P5/30

CPC classification number: C07D307/83 ,  C07D407/04

Abstract: The invention relates to aurones and extracts comprising them useful in the prophylactic and/or therapeutic treatment of an animal (including a human) with an estrogen receptor (ER) related disease or condition of the animal or human body, as well as methods, uses and other inventions related thereto.

Abstract translation: 本发明涉及包含它们可用于预防和/或治疗具有雌激素受体（ER）相关疾病或动物或人体的病症的动物（包括人））的赭色和提取物以及方法，用途 和其他有关的发明。

公开(公告)号：US08962575B2

公开(公告)日：2015-02-24

申请号：US13402675

申请日：2012-02-22

Applicant: Matthias Gehling ,  Torsten Grothe ,  Ernst Roemer ,  Peter Reinemer ,  Kathrin Reinhardt ,  Annie George ,  Nur Hanisah Mohtar ,  Noorsyarida Mohd Sapiai

Inventor： Matthias Gehling ,  Torsten Grothe ,  Ernst Roemer ,  Peter Reinemer ,  Kathrin Reinhardt ,  Annie George ,  Nur Hanisah Mohtar ,  Noorsyarida Mohd Sapiai

IPC: A61K31/70 ,  A61K31/34 ,  C07D407/08 ,  C07D407/04 ,  C07H17/08

CPC classification number: C07D407/08 ,  C07D407/04 ,  C07H17/08

Abstract: The use or methods of use of extracts comprising one or more special clerodane compounds against inflammatory (including allergic) diseases or conditions, as well as novel compounds of this type, said clerodane derivatives for use against inflammatory (including allergic) diseases or conditions, pharmaceutical formulations comprising them especially for use against inflammatory disease or conditions, and related embodiments; said extract and/or compound(s) for use in the treatment or in the preparation of a medicament (including a nutraceutical) for the prophylactic and/or therapeutic treatment of said disease or condition, as well as their preparation; pharmaceutical or nutraceutical formulations comprising said extract and/or natural compound(s) which are useful in said prophylactic and/or therapeutic treatment, and related embodiments.

Abstract translation: 使用或使用包含一种或多种抗炎症（特别是过敏性）疾病或病症的特殊克洛膦酸化合物的提取物以及这种新型化合物的用途，所述用于抗炎症（包括过敏性）疾病或病症的氯化丹烷衍生物，药物 包含它们的制剂，特别是用于抗炎性疾病或病症，以及相关实施方案; 所述提取物和/或化合物用于治疗或制备用于预防和/或治疗所述疾病或病症的药物（包括营养药物）及其制备; 包含可用于所述预防和/或治疗性治疗的所述提取物和/或天然化合物的药物或营养制剂以及相关实施方案。

公开(公告)号：US06518274B1

公开(公告)日：2003-02-11

申请号：US09762448

申请日：2001-04-18

Applicant: Matthias Gehling ,  Jörg Baumgarten ,  Axel Kretschmer ,  Horst-Peter Antonicek ,  Peter Proksch ,  Bambang Wahyu Nugroho ,  Frank Bohnenstengel

Inventor： Matthias Gehling ,  Jörg Baumgarten ,  Axel Kretschmer ,  Horst-Peter Antonicek ,  Peter Proksch ,  Bambang Wahyu Nugroho ,  Frank Bohnenstengel

IPC: A61P910

CPC classification number: A61K31/343 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/908

Abstract: The invention relates to the use of cycloventabenzofuran derivatives for the production of a medicament for the treatment of nuclear factor of &kgr;B-dependent diseases.

Abstract translation: 本发明涉及环烷基苯并呋喃衍生物在制备用于治疗κB依赖性疾病的核因子的药物中的用途。