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11.发明授权Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效级联聚合物复合物，其制备方法和含有所述复合物的药剂
公开(公告)号：US6166200A
公开(公告)日：2000-12-26
申请号：US345807
申请日：1999-07-02
IPC分类号： A61K49/08 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07D487/08 , C07K14/00 , C07D255/02 , A61B5/055 , A61K51/00 , C07D225/00 , C07F5/00
CPC分类号： C07D487/08 , A61K49/04 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001
摘要： Cascade polymer complexes that containa) complexing ligands of general formula IA--{X--[Y--(Z--W--K.sub.W .sub.z).sub.y ].sub.x}.sub.a (I),in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent,a stands for numbers 2 to 12,x, y, z and w, independently of one another, stand for numbers 1 to 4,provides that at least two reproduction units are different and that for the product of the multiplicities,16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64holds true,b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83,c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well asd) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
摘要翻译： 包含a）通式I A- {X- [Y-（Z- + ZW-KW + Z z）y] x} a（I）的络合配体的级联聚合物络合物，其中A代表氮 - 含有碱基多重性a，X和Y的级联核，彼此独立地代表直接键合或者再现多重性x或y，Z和W的级联再现单元，彼此独立地代表级联再现单元 再现倍数z或w，K代表络合剂的基团，a代表数字2至12，x，y，z和w，彼此独立地代表数字1至4，规定至少两个再现 单位是不同的，并且对于多重性的乘积，16
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12.发明授权Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes 失效级联聚合物复合物，其制备方法和含有所述复合物的药剂
公开(公告)号：US6063361A
公开(公告)日：2000-05-16
申请号：US40364
申请日：1998-03-18
IPC分类号： A61K49/00 , A61K20060101 , A61K49/04 , A61K49/08 , A61K49/12 , A61P43/00 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07D487/08 , C07F5/00 , C07K5/04 , C07K14/00 , C08G69/00 , C08G73/02 , C08G85/00 , C08L101/00 , A61B5/055 , C07D225/00 , C08F283/00
CPC分类号： C07D487/08 , A61K49/04 , A61K49/085 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001 , Y10S424/16
摘要： Cascade polymer complexes having a complexing ligand with at least two different reproduction units and having a complexing agent which is a macrocyclic group having an amide grouping or a linear DTPA-type group having a linkage to the polymer through the central nitrogen.
摘要翻译： 具有具有至少两个不同再生单元的络合配体和具有络合剂的级联聚合物络合物，其是具有酰胺基的大环基团或具有通过中心氮与聚合物键合的线性DTPA型基团。
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13.发明授权Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same 失效级联聚合物复合物，其制备方法和含有它的药物
公开(公告)号：US6057419A
公开(公告)日：2000-05-02
申请号：US77773
申请日：1998-06-04
申请人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Bernd Raduchel , Hanns-Joachim Weinmann , Wolfgang Ebert , Bernd Misselwitz , Andreas Muhler , Thomas Frenzel
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/12 , A61K51/00 , C07D295/108 , C07F5/00 , C08G73/06 , C08L79/00
CPC分类号： A61K49/085 , A61K49/04 , A61K49/124 , Y10S514/836
摘要： Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, and that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.64 holds true for the product of the multiplicities and that at least one of cascade reproduction units X, Y, Z, W stands for a 1,4,7,10-tetraazacyclododecane or 1,4,8,11-teraazacyclotetradecane reproduction unit, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides as well as d) optionally acylated terminal amino groups are valuable compounds for diagnosis and therapy.
摘要翻译： PCT No.PCT / EP96 / 05315 Sec。 371日期：1998年6月4日 102（e）日期1998年6月4日PCT 1996年11月29日PCT PCT。 出版物WO97 / 23245 日期1997年7月3日包含a）通式（I）的络合配体的级联聚合物络合物，其中A代表碱基多重性a的含氮级联核，X和Y彼此独立地代表直接 连接或再现多重性的级联再现单位x或y，z和W彼此独立地代表再现倍数z或w的级联再现单位，K表示络合剂的基团，a表示数字2 至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同，并且16
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14.发明授权Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containing these compounds 失效大环聚合物络合剂，它们的络合物，其制备方法和含有这些化合物的药剂
公开(公告)号：US5876698A
公开(公告)日：1999-03-02
申请号：US881269
申请日：1992-05-11
申请人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/06 , C08G69/10 , C08G69/48 , G01N31/00 , G01N33/48
CPC分类号： A61K51/065 , A61K49/085 , A61K49/106 , A61K49/146 , A61K2123/00
摘要： Polymeric compounds of general formula I(M).sub.n A (I)in whichM stands for the radical of a macrocyclic complexing agent,A stands for a backbone molecule, which shows a deficit of n amino groups, n hydroxy groups or n carboxy groups,n stands for the numbers 1 to 400, characterized in thatM, independent of one another, stands for complexing agents of general formula IA ##STR1## in which all variables are defined herein.
摘要翻译： 通式I（M）nA（I）的聚合化合物，其中M代表大环络合剂的基团，A代表主链分子，其表现出n个氨基，n个羟基或n个羧基的缺陷， n代表数字1至400，其特征在于，M彼此独立地代表通式IA（IA）的络合剂，其中所有变量在本文中定义。
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15.发明授权Cascade polymer complexes, process for their production and pharamceutical agents containing said complexes 失效级联聚合物复合物，其生产方法和含有所述复合物的药物
公开(公告)号：US5820849A
公开(公告)日：1998-10-13
申请号：US674844
申请日：1996-07-03
IPC分类号： A61K49/00 , A61K20060101 , A61K49/04 , A61K49/08 , A61K49/12 , A61P43/00 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07D487/08 , C07F5/00 , C07K5/04 , C07K14/00 , C08G69/00 , C08G73/02 , C08G85/00 , C08L101/00 , A61B5/055 , A61K51/04
CPC分类号： C07D487/08 , A61K49/04 , A61K49/085 , A61K49/124 , A61K51/065 , C07C229/76 , C07C237/42 , C07D251/54 , C07D257/02 , C07K14/001 , Y10S424/16
摘要： Cascade polymer complexes that contain a) complexing ligands of general formula I A-{X-�Y-(Z- .sub.Z).sub.y !.sub.x }.sub.a (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different and that for the product of the multiplicities, 16
摘要翻译： 含有a）通式IA- {X- [Y-（Z-
Z）y] x} a（I）的络合配体的级联聚合物络合物，其中A代表含氮级联核 基本多重性a，X和Y彼此独立地代表再现多重性x或y，Z和W的直接键合或级联再现单元，彼此独立地代表再现倍数z的级联再现单位 或w，K表示络合剂的基团，代表数字2至12，x，y，z和w彼此独立地代表数字1至4，条件是至少两个再现单位不同 并且对于多重性的乘积，16 -
16.发明授权
公开(公告)号：US5759518A
公开(公告)日：1998-06-02
申请号：US663233
申请日：1996-10-03
IPC分类号： A61K49/00 , A61K49/12 , A61K49/18 , C08G18/60 , C08G69/00 , C08G73/00 , C08G73/02 , C08G73/06 , C08G83/00 , C08G85/00 , A61B5/055 , A61K49/04 , A61K51/04 , C07F5/00
CPC分类号： A61K49/124 , A61K51/04 , B82Y5/00 , C08G73/0206 , C08G73/06 , C08G83/00
摘要： The invention relates to new metal complexes of dendrimeric macromolecules that contain 8 to 64 ions of an element of atomic numbers 21-129, 39, 42-44, or 57-83 and a polymeric, complexing ligand of formula I A--(X).sub.b (I) in which A, X and b have different meanings, agents that contain these compounds as well as the use of the latter in diagnosis. The invention further relates to a process for the production of the complexes and agents.
摘要翻译： PCT No.PCT / EP94 / 04016 Sec。 371日期：1996年10月3日 102（e）日期1996年10月3日PCT 1994年12月2日PCT公布。 公开号WO95 / 17451 日期：1995年6月29日本发明涉及含有原子序数21-129,39,42-44或57-83的元素的8至64个离子的树枝状大分子的新金属络合物和式IA的聚合物络合配体 - （X）b（I）其中A，X和b具有不同的含义，含有这些化合物的试剂以及后者在诊断中的用途。 本发明进一步涉及生产复合物和试剂的方法。
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17.发明授权公开(公告)号：US06916461B2
公开(公告)日：2005-07-12
申请号：US10197421
申请日：2002-07-18
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： C07D295/22 , A61K49/00 , A61K49/10 , A61P35/00 , A61P43/00 , B65D25/16 , B65D47/08 , B65D83/00 , C07C229/16 , C07C229/22 , C07C229/76 , C07C235/10 , C07C237/08 , C07C237/10 , C07C311/05 , C07C311/06 , C07D257/02 , C07D295/26 , C07F5/00 , C07F13/00 , A61B5/055 , A61K51/00
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
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18.发明授权Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis 失效含有全氟烷基的金属络合物，其制备方法及其在核磁共振诊断中的应用公开(公告)号：US07226578B2
公开(公告)日：2007-06-05
申请号：US10957628
申请日：2004-10-05
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： A61B5/055
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy.The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
摘要翻译： 本发明涉及新的单体，全氟烷基取代的金属络合物，其生产方法及其在诊断和治疗中的应用。 根据本发明的化合物特别适用于核自旋断层扫描（MRT）中的体内造影剂。 它们可优选用作血液池剂和淋巴药剂。
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19.发明授权Metal complexes that contain perfluoroalkly, process for their production and their use in NMR diagnosis 失效含有全氟烷烃的金属络合物，其生产过程及其在核磁共振诊断中的应用公开(公告)号：US06468502B1
公开(公告)日：2002-10-22
申请号：US09435918
申请日：1999-11-08
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Radüchel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel , Bernd Misselwitz , Wolfgang Ebert
IPC分类号： A61K5100
CPC分类号： C07D295/26 , A61K49/0002 , A61K49/0004 , B65D25/16 , B65D47/0847 , B65D83/0055 , C07C229/76 , C07C237/10 , C07D257/02
摘要： The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
摘要翻译： 本发明涉及新的单体，全氟烷基取代的金属络合物，其制备方法及其在诊断和治疗中的用途。根据本发明的化合物特别适用于核自旋断层扫描（MRT）中的体内造影剂。 它们可优选用作血液池剂和淋巴药剂。
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20.发明授权公开(公告)号：US06180113B2
公开(公告)日：2001-01-30
申请号：US08801983
申请日：1997-02-19
申请人： Johannes Platzek , Ulrich Niedballa , Bernd Rad{umlaut over (u)}chel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel
发明人： Johannes Platzek , Ulrich Niedballa , Bernd Rad{umlaut over (u)}chel , Wolfgang Schlecker , Hanns-Joachim Weinmann , Thomas Frenzel
IPC分类号： A61K4900
CPC分类号： C07D295/26 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K49/06 , C07D257/02 , A61K2300/00
摘要： Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.
摘要翻译： 含有全氟烷基的金属络合物的药剂可用于肿瘤治疗和介入放射学。
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