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公开(公告)号：US20130011842A1
公开(公告)日：2013-01-10
申请号：US13619298
申请日：2012-09-14
IPC分类号： G01N21/64
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。
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公开(公告)号：US20110236964A1
公开(公告)日：2011-09-29
申请号：US13153902
申请日：2011-06-06
IPC分类号： C12M1/34
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。
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公开(公告)号：US20100178691A1
公开(公告)日：2010-07-15
申请号：US12730121
申请日：2010-03-23
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译： 实施方案一般涉及用于分析分析物的系统。 该系统可以包括透明基板。 该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。
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公开(公告)号：US07709808B2
公开(公告)日：2010-05-04
申请号：US11749411
申请日：2007-05-16
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6432
摘要： An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substrate and a detector for detecting the fluorescently labeled molecule.
摘要翻译： 实施方案一般涉及用于分析分析物的系统。 该系统可以包括透明基板。 该系统还包括激发光源，其被配置为在靠近透明衬底的位置处诱导荧光标记分子的ev逝波激发和用于检测荧光标记分子的检测器。
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公开(公告)号：US20110278474A1
公开(公告)日：2011-11-17
申请号：US13191276
申请日：2011-07-26
申请人： Richard T. Reel , Eric S. Nordman
发明人： Richard T. Reel , Eric S. Nordman
IPC分类号： G01N21/64
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
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公开(公告)号：US07611614B2
公开(公告)日：2009-11-03
申请号：US11338255
申请日：2006-01-24
CPC分类号： G01N27/44704 , B01L3/502 , B01L2200/0631 , B01L2200/0647 , B01L2300/0645 , B01L2400/0415 , B03C5/026 , G01N1/40 , G01N27/44756 , G01N2001/4038
摘要： Embodiments of methods and devices are disclosed for the manipulation (e.g., concentration, purification, capture, trapping, location, transfer) of analytes, e.g., biomolecules, with respect to analyte-containing solutions, using one or more electric fields.
摘要翻译： 公开了使用一个或多个电场来操纵（例如，浓缩，纯化，捕获，捕获，捕获，捕获，捕获，捕获，捕获，捕获，转移）分析物（例如生物分子）的方法和装置的实施方案。
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公开(公告)号：US06596140B2
公开(公告)日：2003-07-22
申请号：US09846855
申请日：2001-05-01
申请人： Eric S. Nordman , Richard T. Reel
发明人： Eric S. Nordman , Richard T. Reel
IPC分类号： G01N27447
CPC分类号： G01N27/44704 , G01N27/44721 , G01N27/44782
摘要： Embodiments of a device and method are described which provide for control over the distortion of a sample zone upon exiting an electrophoresis separation channel. According to the teachings herein (i) the downstream regions of the channels, near the outlet ends, and/or (ii) the detection chamber, is/are configured so that distortion of one or more sample zones passing from the channels into and across the detection chamber can be controlled (e.g., reduced) in a fashion affording enhanced detectability. In certain embodiments, the lumens along the end regions of the separation channels progressively expand.
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公开(公告)号：US20120196296A1
公开(公告)日：2012-08-02
申请号：US13442143
申请日：2012-04-09
IPC分类号： G01N21/64
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。
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公开(公告)号：US07177023B2
公开(公告)日：2007-02-13
申请号：US10805096
申请日：2004-03-19
申请人： Richard T. Reel , Eric S. Nordman
发明人： Richard T. Reel , Eric S. Nordman
IPC分类号： G01J3/30
CPC分类号： G01N21/645 , G01N21/0303 , G01N2021/0346 , G01N2021/6417 , G01N2021/6478
摘要： System and method for fluorescent light detection from biological samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译： 用于生物样品的荧光检测的系统和方法，以增强数值孔径和/或减少荧光灯的串扰。
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公开(公告)号：US20100032298A1
公开(公告)日：2010-02-11
申请号：US12580220
申请日：2009-10-15
IPC分类号： G01N27/26
CPC分类号： G01N27/44704 , B01L3/502 , B01L2200/0631 , B01L2200/0647 , B01L2300/0645 , B01L2400/0415 , B03C5/026 , G01N1/40 , G01N27/44756 , G01N2001/4038
摘要： Embodiments of methods and devices are disclosed for the manipulation (e.g., concentration, purification, capture, trapping, location, transfer) of analytes, e.g., biomolecules, with respect to analyte-containing solutions, using one or more electric fields.
摘要翻译： 公开了使用一个或多个电场来操纵（例如，浓缩，纯化，捕获，捕获，捕获，捕获，捕获，捕获，捕获，捕获，转移）分析物（例如生物分子）相对于含分析物的溶液的实施方案。
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