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公开(公告)号：US5908400A
公开(公告)日：1999-06-01
申请号：US878852
申请日：1997-06-20
申请人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
发明人： Naruhito Higo , Hirotoshi Adachi , Tatsuya Meno
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325 , A61N1/0448
摘要： An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer containing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode while in use, and (c) a drug layer containing a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.
摘要翻译： 提供了使用溶解型的离子电渗疗法器件结构，其中电离药物经皮或经粘膜施用于生物体。 该装置结构包括（a）不可极化电极，（b）含有离子交换树脂的亲水性聚合物凝胶层，其能够在使用时特异性地抑制从电极溶出的离子的移动，以及（c） 在药物保持膜中含有处于干燥状态的药物的药物层，其中当使用所述装置时，使所述药物层与所述亲水性聚合物凝胶层接触，使得干燥条件下的所述药物溶解。 保湿剂可以包含在亲水性聚合物凝胶层和/或药物层中。
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公开(公告)号：US20070264316A1
公开(公告)日：2007-11-15
申请号：US10584172
申请日：2004-12-27
申请人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
发明人： Hirotoshi Adachi , Naruhito Higo , Seiji Tokumoto
IPC分类号： A61F13/02
CPC分类号： A61K9/703 , A61F13/0203 , A61K9/7084
摘要： Provided a patch activated in use capable of uniformly activating a drug by supplying a solution when used. The patch activated in use comprises an absorber 11 containing a dry drug 10 and formed of a material capable of absorbing a liquid, a wall material 13 arranged around the absorber 11 and having an adhesive layer 12 on the lower surface thereof, a support 15 arranged on the absorber 11 and the wall material 13 and having an opening 14 at the center, a diaphragm 20 arranged on the support 15, and a dissolution liquid reservoir 18 arranged on the diaphragm 20, holding a dissolution liquid dissolving the drug in a space with the diaphragm 20 and having a protruding portion 17 which breaks the diaphragm 20 by pressure. The protruding portion 17 has a liner top end portion and arranged in contact or in the proximity with the diaphragm 20. A liner 19 is detachably provided on the lower surface of the absorber 11 and adhesive layer 12.
摘要翻译： 提供使用时能够通过在使用时提供溶液来均匀地活化药物的活化片。 在使用中活化的贴片包括含有干药10并由能够吸收液体的材料形成的吸收体11，围绕吸收体11排列并且在其下表面上具有粘合层12的壁材13， 在吸收器11和壁材料13上，中心具有开口14，设置在支撑体15上的隔膜20和布置在隔膜20上的溶解液储存器18，将溶解药物的溶解液保持在空间中， 隔膜20具有突出部分17，其通过压力破坏隔膜20。 突出部分17具有衬里顶端部分并且与隔膜20接触或邻近设置。衬垫19可拆卸地设置在吸收体11和粘合剂层12的下表面上。
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公开(公告)号：US20070250018A1
公开(公告)日：2007-10-25
申请号：US11659894
申请日：2005-08-11
申请人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
发明人： Hirotoshi Adachi , Seiji Tokumoto , Naruhito Higo
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61M2037/0023
摘要： A transdermal drug administration system with microneedles which can perforate the skin (stratum corneum) by a simple operation at the time of transdermal administration of a physiologically active substance (drug) is provided. The present transdermal drug administration system with microneedles comprises microneedle device (50) having a plurality of microneedles (51) which can perforate the skin and a plurality of solution passages (52); absorbent (11) which is disposed on microneedle device (50), comprising dried drug (10) and a material which can absorb liquid; and dissolution liquid reservoir (18) which is disposed on absorbent (11) and stores dissolution liquid (16) for dissolving drug (10) and in which a diaphragm (20) provided between absorbent (11) can be broken by pressing. Dissolution liquid reservoir (18) is pressed to break diaphragm (20), and at the same time, the microneedle (51) perforates the skin (stratum corneum), and drug (10) dissolved in dissolution liquid (16) is transmitted through microneedle device (50) to the skin.
摘要翻译： 提供了一种透皮给药系统，其具有通过在经皮给药生理活性物质（药物）时通过简单操作穿透皮肤（角质层）的微针。 本发明的具有微针的透皮药物给药系统包括具有能使皮肤穿孔的多个微针（51）和多个溶液通道（52）的微针装置（50）。 吸收剂（11），其设置在微针装置（50）上，包括干燥药物（10）和能够吸收液体的材料; 和溶解液储存器（18），其设置在吸收剂（11）上并储存用于溶解药物（10）的溶解液体（16），并且其中设置在吸收剂（11）之间的隔膜（20）可以通过压制而破裂。 溶解液体储存器（18）被按压以打破隔膜（20），同时微针（51）穿透皮肤（角质层），溶解在溶解液体（16）中的药物（10）通过微针 装置（50）到皮肤。
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公开(公告)号：US06546282B1
公开(公告)日：2003-04-08
申请号：US09556174
申请日：2000-04-20
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： A handling-convenient device for iontophoresis, which can supply spotted regions suffering from disease with a proper quantity of current at the same time. The device for iontophoresis includes a power source apparatus having a plurality of output terminals outputting currents of predetermined values adjusted by a plurality of current control circuits, respectively, and a plurality of connecting cords, each cord being connected with one of the output terminals of the power source apparatus at one end thereof and being connected with an electrode structure at the other end. The connecting cords are attached with the power source apparatus in a mutually attachable/detachable fashion via connection terminals. The power source apparatus has an LED located thereon to notify of the energization status of the device and a power switch externally located thereon to control starts and stops of the apparatus.
摘要翻译： 用于离子电渗疗法的便于操作的装置，可同时为适量的电流供应患有疾病的斑点。 用于离子电渗疗法的装置包括：电源装置，具有多个输出端子，分别输出由多个电流控制电路调节的预定值的电流;以及多个连接线，每个电线与其中一个输出端子 电源装置的另一端与电极结构连接。 连接线通过连接端子以可相互连接/拆卸的方式与动力源装置连接。 电源装置具有位于其上的LED，用于通知设备的通电状态和外部位于其上的电源开关以控制设备的启动和停止。
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15.发明申请Adjuvant or Pharmaceutical Preparation for Transdermal or Transmucousal Administration 审中-公开辅助剂或透皮或透粘膜给药的药物制剂公开(公告)号：US20090130127A1
公开(公告)日：2009-05-21
申请号：US11997413
申请日：2006-07-31
IPC分类号： A61K39/39 , A61K31/201 , A61K31/341 , A61K31/045 , A61K31/23
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译： 一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 R 1和R 2独立地表示碳原子数1〜16的烷基侧链。
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公开(公告)号：US20090318845A1
公开(公告)日：2009-12-24
申请号：US12087054
申请日：2006-12-25
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044
摘要： To provide an easily producible mass-production type iontophoresis device having a structure that a dissolution liquid-storing container is integrated with an iontophoresis electrode, a dissolution liquid and a drug can be mixed by simple operations, and it is free from a risk of leakage of electricity. The device comprises an electrode film having an electrode layer (2) formed on a base (1), a drug-loaded member (3) arranged on the electrode-layer-forming side of the electrode film, and a dissolution liquid-storing container (5) arranged on the non-electrode-layer-forming side of the electrode film, wherein the electrode film is provided with a dissolution liquid passing hole (9), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode film via an aluminum lid member (7) which covers the dissolution liquid passing hole (9), and the aluminum lid member (7) is arranged within the flange outer diameter of the dissolution liquid-storing container.
摘要翻译： 为了提供容易生产的批量生产型离子电渗疗法装置，其具有溶解液储存容器与离子电渗电极结合的结构，溶解液和药物可以通过简单的操作混合，并且没有泄漏的风险 的电力。 该装置包括具有形成在基底（1）上的电极层（2）和布置在电极膜的电极层形成侧的药物负载构件（3）的电极膜和溶解液储存容器 （5），设置在电极膜的非电极层形成侧，其中电极膜设置有溶解液通过孔（9），溶解液储存容器（5）的凸缘（5a） 通过覆盖溶解液通过孔（9）的铝盖构件（7）与电极膜接合，铝盖构件（7）配置在溶解液储存容器的凸缘外径内。
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公开(公告)号：US20090221952A1
公开(公告)日：2009-09-03
申请号：US12087055
申请日：2006-12-25
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： To provide an easily producible mass-production type transdermal drug device having a structure that a dissolution liquid and a drug can be mixed by simple operations. The device comprises an electrode holder (1) having an electrode layer (1b) formed on a substrate (1a), a drug-loaded member (2) provided on a surface of the electrode holder (1) for forming the electrode layer (1b), and a dissolution liquid-storing container (5) provided on a surface of the electrode holder (1) for not forming the electrode layer (1b), wherein a dissolution liquid passing hole (8) is formed in the electrode holder (1), a flange (5a) of the dissolution liquid-storing container (5) is bonded to the electrode holder (1) via a lid material (6) covering the dissolution liquid passing hole (8), the dissolution liquid-storing container (5) has a protrusion (5b) opposing the dissolution liquid passing hole (8), and the protrusion (5b) has a recessed surface at the tip.
摘要翻译： 提供一种易于生产的批量生产型透皮药物装置，其具有可以通过简单的操作混合溶解液体和药物的结构。 该装置包括具有形成在基板（1a）上的电极层（1b）的电极保持器（1），设置在用于形成电极层（1b）的电极保持器（1）的表面上的药物负载部件 ）和设置在不形成电极层（1b）的电极保持件（1）的表面上的溶解液储存容器（5），其中在电极保持器（1）中形成溶解液通孔（8） ），溶解液储存容器（5）的凸缘（5a）通过覆盖溶解液通过孔（8）的盖材料（6），溶解液储存容器（ 5）具有与溶解液通过孔（8）相对的突起（5b），突起（5b）在尖端具有凹陷表面。
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18.发明申请Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration 有权用于透皮或经粘膜给药的佐剂或药物制剂公开(公告)号：US20120156258A1
公开(公告)日：2012-06-21
申请号：US13367679
申请日：2012-02-07
CPC分类号： A61K39/39 , A61K9/0009 , A61K9/0014 , A61K9/0021 , A61K9/006 , A61K39/145 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/34 , A61K2039/53 , A61K2039/54 , A61K2039/541 , A61K2039/55511 , A61M37/0092 , A61N1/325 , A61N1/327 , C12N7/00 , C12N2760/16034 , Y02A50/401
摘要： An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
摘要翻译： 一种用于经皮或经粘膜给药的佐剂，其包含至少一种选自脂族醇，游离脂肪酸和脂肪酸衍生物的物质，但不含下式表示的物质：其中R3和R4可以一起形成环状 ，R 1和R 2独立地表示碳原子数1〜16的烷基侧链。
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公开(公告)号：US20100022942A1
公开(公告)日：2010-01-28
申请号：US12441842
申请日：2007-08-31
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/044
摘要： The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member (1) and an electrode layer (2) and having a dissolution liquid passage hole (9), a drug impregnation member (3) mounted on the electrode layer (2) side of the electrode film, and a dissolution liquid storage container (5) bonded to the base member (1) side of the electrode film via a lid member (7) covering the solution passage hole (9). The dissolution liquid storage container (5) comprises a bottom and a sidewall. A protrusion (5b) which faces the dissolution liquid passage hole (9) is provided at the center of the bottom, and the sidewall is provided with a vertically folded part (5c).
摘要翻译： 本发明提供了一种用于经皮吸收制剂的装置，其具有能够独立于力水平显示良好的溶液迁移的溶液储存容器。 用于经皮吸收制剂的装置包括：电极膜，包括基底部件（1）和电极层（2），并具有溶解液体通过孔（9）;药物浸渍部件（3），安装在电极层 ）侧，以及通过覆盖所述溶液通孔（9）的盖部件（7）与所述电极膜的基材（1）侧接合的溶解液收容容器（5）。 溶解液储存容器（5）包括底部和侧壁。 在底部的中心设有面向溶解液通路孔（9）的突起（5b），侧壁设有垂直折叠部（5c）。
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公开(公告)号：US20070255195A1
公开(公告)日：2007-11-01
申请号：US11659908
申请日：2005-08-11
申请人： Hirotoshi Adachi
发明人： Hirotoshi Adachi
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444 , A61N1/30 , A61N1/325
摘要： An iontophoresis device which allows excellent transdermal absorption of an anionically chargeable physiologically active substance is provided. The iontophoresis device comprises a cathode (25) and an interface (31) or (32) composed of a cationically chargeable membrane, wherein an anionically chargeable physiologically active substance (drug) (10) is placed between the cathode (25) and the interface (31) or in the interface (32). A wall member (13) with an adhesive layer (12) in the bottom is placed around an absorbent (11), and a support (15) having an opening (14) in the center is placed on the absorbent (11) and the wall member (13). When the device is used, the dissolution liquid for the drug is supplied to the absorbent (11) through the opening (14). The absorbent (11) and the interface (31) or (32) become wet with the dissolution liquid and the drug (10) is activated uniformly.
摘要翻译： 提供了允许对阴离子可带电的生理活性物质进行极好的透皮吸收的离子电渗疗法装置。 离子电渗装置包括阴极（25）和由可阳离子电荷的膜构成的界面（31）或（32），其中阴极可带电的生理活性物质（药物）（10）被放置在阴极（25）和界面 （31）或接口（32）中。 在吸收体11的周围放置有在底部具有粘合剂层12的壁部件13，在吸收体11上设有具有中央部的开口部14的支承体15， 壁构件（13）。 当使用该装置时，用于药物的溶解液通过开口（14）供给到吸收剂（11）。 吸收剂（11）和界面（31）或（32）变得被溶解液弄湿，药物（10）被均匀地活化。
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