公开(公告)号：US20230011869A1

公开(公告)日：2023-01-12

申请号：US17349800

申请日：2021-06-16

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Nawaz KHAN ,  Christian KRAMER ,  Christian LERNER ,  Philippe PFLIEGER ,  Theodor STOLL ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US20190321440A1

公开(公告)日：2019-10-24

申请号：US16389292

申请日：2019-04-19

Applicant: Hoffmann-La Roche Inc.

Inventor： Konrad BLEICHER ,  Daniella CHEANG ,  Patrick DI GIORGIO ,  Taishan HU ,  Christian JENNY ,  Patrizio MATTEI ,  Petra SCHMITZ ,  Theodor STOLL

IPC: A61K38/12 ,  A61P31/04

Abstract: The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.