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公开(公告)号：US20210009589A1
公开(公告)日：2021-01-14
申请号：US17034240
申请日：2020-09-28
Applicant: Hoffmann-La Roche Inc.
Inventor： Jérôme HERT , Daniel HUNZIKER , Patrizio MATTEI , Markus RUDOLPH , Petra SCHMITZ , Patrick DI GIORGIO
IPC: C07D471/04 , A61K9/20 , A61K9/48 , C07D401/14 , C07D405/14 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
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![OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL](/abs-image/US/2021/01/21/US20210015792A1/abs.jpg.150x150.jpg)
公开(公告)号：US20210015792A1
公开(公告)日：2021-01-21
申请号：US17034323
申请日：2020-09-28
Applicant: Hoffmann-La Roche Inc.
Inventor： Patrizio MATTEI , Daniel HUNZIKER , Patrick DI GIORGIO , Jerome HERT , Markus RUDOLPH , Lisha WANG
IPC: A61K31/407 , C07D209/56 , C07D487/04
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20200223854A1
公开(公告)日：2020-07-16
申请号：US16832553
申请日：2020-03-27
Applicant: Hoffmann-La Roche Inc.
Inventor： Patrick DI GIORGIO , Jerome HERT , Daniel HUNZIKER , Patrizio MATTEI , Markus RUDOLPH , Petra SCHMITZ , Christoph ULLMER
IPC: C07D487/04 , A61K31/5517 , A61K31/407 , C07D471/04 , A61K31/437 , A61P27/02
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
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Patent Agency Ranking
公开(公告)号：US20200002336A1
公开(公告)日：2020-01-02
申请号：US16569459
申请日：2019-09-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Jérôme HERT , Daniel HUNZIKER , Patrizio MATTEI , Markus RUDOLPH , Petra SCHMITZ , Patrick DI GIORGIO
IPC: C07D471/04 , C07D405/14 , C07D498/04 , C07D401/14 , C07D519/00 , C07D513/04 , C07D495/04 , A61K9/20 , A61K9/48
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20200002297A1
公开(公告)日：2020-01-02
申请号：US16569475
申请日：2019-09-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Patrizio MATTEI , Jérôme HERT , Daniel HUNZIKER , Markus RUDOLPH , Petra SCHMITZ , Patrick DI GIORGIO , Justin GOMME
IPC: C07D257/04 , C07D405/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D401/10 , C07D403/10 , C07D417/14 , C07D401/06 , C07D409/14
Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
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公开(公告)号：US20240050516A1
公开(公告)日：2024-02-15
申请号：US18379626
申请日：2023-10-12
Applicant: Hoffmann-La Roche Inc.
Inventor： Konrad BLEICHER , Daniella CHEANG , Patrick DI GIORGIO , Taishan HU , Christian JENNY , Patrizio MATTEI , Petra SCHMITZ , Theodor STOLL
Abstract: The present invention provides compounds of formula (I)
wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.-
7.发明申请公开(公告)号：US20200216457A1
公开(公告)日：2020-07-09
申请号：US16827136
申请日：2020-03-23
Applicant: Hoffmann-La Roche Inc.
Inventor： Patrick DI GIORGIO , Jerome HERT , Daniel HUNZIKER , Holger KUEHNE , Patrizio MATTEI , Markus RUDOLPH
IPC: C07D487/04 , A61P3/00 , A61P1/16 , C07D519/00
Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
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公开(公告)号：US20190321440A1
公开(公告)日：2019-10-24
申请号：US16389292
申请日：2019-04-19
Applicant: Hoffmann-La Roche Inc.
Inventor： Konrad BLEICHER , Daniella CHEANG , Patrick DI GIORGIO , Taishan HU , Christian JENNY , Patrizio MATTEI , Petra SCHMITZ , Theodor STOLL
Abstract: The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
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