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18 条记录 (耗时 0.031 秒)

    Measurement of vitamin D
    11.
    发明授权
    Measurement of vitamin D 有权
    维生素D的测定

    公开(公告)号：US08003400B2

    公开(公告)日：2011-08-23

    申请号：US12326972

    申请日：2008-12-03

    申请人： Uwe Kobold ,  Thomas Duelffer ,  Michael Grol ,  Rupert Herrmann ,  Herbert Von der Eltz ,  Leopold Von Proff

    发明人： Uwe Kobold ,  Thomas Duelffer ,  Michael Grol ,  Rupert Herrmann ,  Herbert Von der Eltz ,  Leopold Von Proff

    IPC分类号： G01N33/00

    CPC分类号： G01N33/82 ,  Y10T436/20 ,  Y10T436/203332

    摘要： The present invention relates to a method of measuring a vitamin D metabolite in a sample, the method comprising the steps of (a) treating said sample with a vitamin D metabolite releasing reagent under conditions appropriate to release a vitamin D metabolite from vitamin D-binding protein and not to cause protein precipitation, (b) subjecting the treated sample obtained in step (a) to a chromatographic separation, and (c) measuring a vitamin D metabolite during or after said chromatographic separation. The present invention also relates to methods for determining the vitamin D status of a subject, for use in the diagnosis of disease, and to agents and kits for use in performing the methods of the invention.

    摘要翻译： 本发明涉及一种测量样品中维生素D代谢物的方法，所述方法包括以下步骤：（a）在适于从维生素D结合物释放维生素D代谢物的条件下用维生素D代谢物释放试剂处理所述样品 蛋白质，不会引起蛋白质沉淀，（b）使步骤（a）中得到的处理样品进行色谱分离，和（c）在所述色谱分离期间或之后测量维生素D代谢物。 本发明还涉及确定用于疾病诊断的受试者的维生素D状态的方法以及用于实施本发明的方法的试剂和试剂盒。

    Monoclonal antibodies against the epitope YPYDVPDYA, a process for their production and their use
    15.
    发明授权
    Monoclonal antibodies against the epitope YPYDVPDYA, a process for their production and their use 失效
    针对表位YPYDVPDYA的单克隆抗体，其生产过程及其应用

    公开(公告)号：US07255859B1

    公开(公告)日：2007-08-14

    申请号：US09284787

    申请日：1997-10-20

    申请人： Thomas Emrich ,  Matthias Hinzpeter ,  Michael Grol

    发明人： Thomas Emrich ,  Matthias Hinzpeter ,  Michael Grol

    IPC分类号： A61K39/145

    CPC分类号： C07K16/1018

    摘要： The invention concerns monoclonal antibodies against the epitope YPYDVPDYA (SEQ ID NO: 1) which is derived from the haemagglutinin of the human influenza virus and are suitable for the detection and isolation of native haemagglutinin of the human influenza virus, of modified haemagglutinin or of haemagglutinin fusion proteins and have an affinity of >108 M−1, in particular of 109 to 1010 M−1.

    摘要翻译： 本发明涉及来自人流感病毒血凝素的表位YPYDVPDYA（SEQ ID NO：1）的单克隆抗体，并且适用于检测和分离人流感病毒，修饰血细胞凝集素或血细胞凝集素的天然血凝素 融合蛋白，并且具有> 10 -8 M -1的亲和力，特别是10 9至10 10 / M <-1> 。