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    Disposable, integrated microfluidic cartridge and methods of making and using same
    12.
    发明授权
    Disposable, integrated microfluidic cartridge and methods of making and using same 有权

    公开(公告)号：US10767219B2

    公开(公告)日：2020-09-08

    申请号：US15125124

    申请日：2015-03-11

    Applicant: Illumina, Inc.

    Inventor： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC: B01L3/00 ,  C12Q1/6869 ,  B01L7/00 ,  C12Q1/6806 ,  C40B60/06

    Abstract: The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed.

    Flow cell cartridge
    15.
    外观设计
    Flow cell cartridge 有权

    公开(公告)号：USD1012313S1

    公开(公告)日：2024-01-23

    申请号：US29864480

    申请日：2022-05-31

    Applicant: Illumina, Inc.

    Designer： Jay Taylor ,  James Osmus ,  Philip Paik ,  Jack Godfrey Wood ,  Carlos Dominguez

    Abstract: FIG. 1 is a top, rear perspective view of a flow cell cartridge comprising our new design;
    FIG. 2 is a top plan view thereof;
    FIG. 3 is a bottom plan view thereof;
    FIG. 4 is a left side elevational view thereof;
    FIG. 5 is a right side elevational view thereof;
    FIG. 6 is a front elevational view thereof; and,
    FIG. 7 is an enlarged rear elevational view thereof.
    The evenly broken lines shown in the drawings illustrate portions of the flow cell cartridge that form no part of the claimed design.

    Disposable, integrated microfluidic cartridge and methods of making and using same
    17.
    发明授权
    Disposable, integrated microfluidic cartridge and methods of making and using same 有权

    公开(公告)号：US11174513B2

    公开(公告)日：2021-11-16

    申请号：US16405547

    申请日：2019-05-07

    Applicant: ILLUMINA, INC.

    Inventor： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/6869 ,  C12Q1/6806 ,  C12Q1/68

    Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

    DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME
    18.
    发明申请
    DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME 审中-公开

    公开(公告)号：US20190264276A1

    公开(公告)日：2019-08-29

    申请号：US16405547

    申请日：2019-05-07

    Applicant: ILLUMINA, INC.

    Inventor： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC: C12Q1/6869 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6806

    Abstract: A stack of fluidics layers of a microfluidic cartridge for sequencing nucleic acid molecules includes a sequencing chamber layer having a sequencing chamber area configured for carrying out clustering and sequencing reactions, and a sequencing chamber bottom layer disposed under the sequencing chamber layer. The sequencing chamber bottom layer has an opening configured to hold an image sensor with the image sensor having an active area disposed under the sequencing chamber area. The sequencing chamber area spans substantially all of the active area of the image sensor. The stack of fluidics layers includes a flexible printed circuit board (PCB) layer under the sequencing chamber bottom layer, and a fluidics channels layer disposed under the flexible PCB layer. The fluidics channels layer includes fluidics channels that are configured to deliver reactants to the sequencing chamber area. The fluidics channels do not substantially overlap with the active area of the image sensor.

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