公开(公告)号：US20240307871A1

公开(公告)日：2024-09-19

申请号：US18675633

申请日：2024-05-28

Applicant: Life Technologies Corporation

Inventor： Mark Reed ,  David Marran ,  Earl Zergiebel ,  Zheng (Derek) Xing

IPC: B01L3/00 ,  C12Q1/6874

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  C12Q1/6874 ,  B01L2200/026 ,  B01L2200/06 ,  B01L2300/0609 ,  B01L2300/0636 ,  B01L2300/0848

Abstract: A cartridge includes a housing having first and second major surfaces and defining a guide mechanism; and a plurality of containers disposed in the housing, each container of the plurality of containers having a receptacle and a lid, the lid formed of a clip and a seal, the clip to secure the seal to the receptacle, a frit disposed in the receptacle in an enclosed space defined by the receptacle and the seal, the seal having an inlet and an outlet in fluid communication with an enclosed space, the frit including a nucleotide concentrate.

公开(公告)号：US12083517B2

公开(公告)日：2024-09-10

申请号：US18094605

申请日：2023-01-09

Applicant: Brian David Babcock

Inventor： Brian David Babcock

IPC: B01L3/00 ,  B81C1/00

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502746 ,  B81C1/00206 ,  B01L2200/06 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/16 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0493 ,  B01L2400/088 ,  B81B2201/058

Abstract: A microfluidic product utilizing gradient surface energy coatings for fluid control comprising a plurality of fluid passages wherein at least one fluid passage comprises a coating configured to control liquid flow wherein the coating configured to control liquid flow comprises a gradient surface energy coating from a proximal location to a distal location on a surface of the fluid passage. The product can include uniform regions and surface gradient regions in the same passage. Coating compositions and product dimensions can be selected to provide control over different flow properties including fluid velocity, reduction and acceleration of fluid flow, and starting and stopping fluid flow.

公开(公告)号：US12064761B2

公开(公告)日：2024-08-20

申请号：US16401805

申请日：2019-05-02

Applicant: Illumina, Inc.

Inventor： Cyril Delattre ,  Minsoung Rhee ,  Jeffrey Liu ,  Wesley Cox-Muranami ,  Paul Crivelli ,  Jennifer Foley ,  Darren Segale ,  Jay Taylor ,  Matthew Hage ,  Philip Paik ,  Erik Allegoren ,  David Hertzog ,  Alex Moroz-Smietana ,  Xiaoxiao Ma ,  Tsukasa Takahashi ,  Brandon Westerberg

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/527 ,  B01L2200/027 ,  B01L2200/06 ,  B01L2200/16 ,  B01L2300/0887

Abstract: An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

公开(公告)号：US20240252078A1

公开(公告)日：2024-08-01

申请号：US18632937

申请日：2024-04-11

Applicant: Becton, Dickinson and Company

Inventor： Alexander James Blake ,  Sylvine Raverdy-Wilson ,  Adam Edelhauser

IPC: A61B5/15 ,  A61B5/145 ,  A61B5/153 ,  A61B5/154 ,  B01L3/00

CPC classification number: A61B5/150274 ,  A61B5/14542 ,  A61B5/150351 ,  A61B5/154 ,  B01L3/50825 ,  A61B5/145 ,  A61B5/15 ,  A61B5/153 ,  B01L3/50 ,  B01L3/5082 ,  B01L2200/06 ,  B01L2200/0684 ,  B01L2300/04 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/14

Abstract: A biological liquid collection device designed to draw blood using an “atmospheric-balanced vacuum” to ensure the blood is exposed to the sample atmospheric partial pressure oxygen and partial pressure carbon dioxide levels as found in standard arterial blood gas syringes, resulting in blood gas sample stabilization during collection and a superior vacuum shelf-life by reducing the gas permeation rate through the plastic tube. The biological liquid collection device comprises a collection module for receiving a biological liquid sample, an evacuated container having an open end and a closed end wherein the evacuated container contains the collection module therein, and a closure for closing the open end of the evacuated container. The evacuated container comprises a gas composition that is substantially equal to the gas composition of the atmosphere outside of the evacuated container. A method for forming the atmospherically balanced vacuum collection device is also provided.

公开(公告)号：US20230364605A1

公开(公告)日：2023-11-16

申请号：US18141179

申请日：2023-04-28

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Lambertus Hesselink ,  Punnag Padhy ,  Mohammad Zaman ,  Ronald Davis ,  Michael Jensen

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502792 ,  B01L2200/06 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0858 ,  B01L2300/0877 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/0427

Abstract: Provided are methods of engulfing particles into droplets. The methods use a microfluidic device comprising a droplet generator and a chamber, the chamber comprising a liquid medium disposed on a voltage supply electrode and a ground electrode. The methods comprise dispensing a particle and a droplet into the liquid medium, and dielectrophoretically trapping the particle and the droplet using the voltage supply electrode and the ground electrode. The methods further comprise engulfing the particle into the droplet, wherein the engulfing comprises increasing a supply voltage between the voltage supply electrode and the ground electrode, thereby moving the droplet toward the voltage supply electrode and engulfing the particle into the droplet. In certain embodiments, the methods further comprise modifying the engulfed particle, assessing the engulfed particle, or both. Devices that find use in practicing the methods of the present disclosure are also provided.

公开(公告)号：US20230234060A1

公开(公告)日：2023-07-27

申请号：US17612822

申请日：2021-10-08

Applicant: INJE UNIVERSITY INDUSTRY- ACADEMIC COOPERATION FOUNDATION

Inventor： Ki Ho HAN ,  Jun Hyeong KIM

IPC: B01L3/00 ,  G01N27/10 ,  G01N15/02 ,  G01N15/00

CPC classification number: B01L3/502784 ,  G01N27/10 ,  G01N15/02 ,  B01L2300/0645 ,  B01L2200/06 ,  G01N2015/0003

Abstract: Provided are an active droplet generating apparatus capable of controlling a droplet size, a method of controlling a droplet size using the same, and a self-diagnosis apparatus for diagnosing generation of a droplet, the active droplet generating apparatus including: a disposable microchannel upper plate; a multifunctional lower plate separated from the disposable microchannel upper plate and configured to be permanently used separately from the disposable microchannel upper plate; a functional polymeric film provided on a lower surface of the upper plate; a negative pressure forming means; and a flow velocity control device configured to adjust the droplet size to a desired size by receiving, by feedback, the voltage value measured by the droplet measuring electrode and controlling flow velocities of the oil and the sample, thereby controlling the droplet size in a feedback control manner by quickly and accurately measuring the droplet size using a capacitance impedance technique.

公开(公告)号：US20190022638A1

公开(公告)日：2019-01-24

申请号：US16143229

申请日：2018-09-26

Applicant: Moishe Bodner

Inventor： Moishe Bodner

IPC: B01L3/00 ,  A61B10/00 ,  G01N1/28

CPC classification number: B01L3/5023 ,  A61B10/0045 ,  A61B10/0051 ,  B01L2200/06 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/12 ,  G01N1/28

Abstract: A splittable fluid sample collector for dividing a fluid sample into two or more portions, includes at least first and second fluid collector portions detachably connected to one another, each of the fluid collector portions including a handle and an absorbent sample pad affixed to an end of the handle. Further, a fluid sampling apparatus includes the aforementioned splittable fluid sample collector, at least one container and a closure for the container. Still further, a method for splitting a fluid sample including providing the aforementioned splittable fluid sample collector, collecting a fluid sample with the absorbent sample pads of the splittable fluid sample collector and splitting the first and second fluid collector portions of the splittable fluid sample collector from one another.

公开(公告)号：US20180272331A1

公开(公告)日：2018-09-27

申请号：US15562358

申请日：2016-03-25

Applicant: BODITECH MED INC.

Inventor： Eui Yul CHOI ,  Hoo Don JOO ,  Byeong Chul KIM ,  Kyong-Hwa CHONG ,  Jae Min LEE ,  Min Seok CHA ,  Sung Mi JU ,  Hye Jin LEE ,  Myung Hee SON ,  Do Won KIM ,  Sang Hyun PARK

IPC: B01L3/02

CPC classification number: B01L3/021 ,  B01L2200/06 ,  B01L2200/0605 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2400/0406

Abstract: The present disclosure provides a device for preparing and dispensing biological sample. Sampling, mixing of the sample with a specific solution, and loading of the mixture, can be achieved in an accurate and convenient manner.

公开(公告)号：US20180224361A1

公开(公告)日：2018-08-09

申请号：US15887855

申请日：2018-02-02

Applicant: Theranos, Inc.

Inventor： Clarissa Lui ,  Priyanshu Gupta

IPC: G01N1/40 ,  G01N33/49 ,  B01L3/00

CPC classification number: G01N1/4077 ,  B01L3/5021 ,  B01L3/5023 ,  B01L2200/025 ,  B01L2200/06 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2300/047 ,  B01L2300/0609 ,  B01L2300/069 ,  B01L2300/0858 ,  B01L2300/0867 ,  B01L2400/0409 ,  G01N33/491 ,  G01N2001/4083

Abstract: Devices, systems and methods for holding and transferring small volume fluid samples are disclosed. Holding vessels, including holding vessels having two or more internal compartments for holding small volume fluid samples, are disclosed. Transfer vessels for receiving small volume fluid samples from such holding vessels are disclosed. Transfer vessels for combining small volume fluid samples from such holding vessels are disclosed. Methods for providing small volume fluid samples for analysis with small loss of sample are disclosed. Methods for providing small volume fluid samples for analysis using automated sample analysis devices and systems, with small loss of sample, are disclosed.

公开(公告)号：US20180178213A1

公开(公告)日：2018-06-28

申请号：US15855913

申请日：2017-12-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Joshua RITCHEY ,  Yi XUE ,  Robert MELTZER

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502707 ,  B01L3/502784 ,  B01L2200/06 ,  B01L2300/12 ,  B01L2300/165 ,  B01L2400/04 ,  B81C1/00206 ,  C09D183/00 ,  C09D183/04 ,  C12Q1/686 ,  C08K3/36

Abstract: Compositions, devices, and methods are disclosed for the modification of polymer surfaces with coatings having a dispersion of silicone polymer and hydrophobic silica. The surface coatings provide the polymer surface with high hydrophobicity, as well as increased resistance to biofouling with proteinaceous material. The polymer surfaces can be particularly useful in microfluidic devices and methods that involve the contacting of the covalently modified polymer surfaces with emulsions of aqueous droplets containing biological macromolecules within an oil carrier phase.