公开(公告)号：US11307133B2

公开(公告)日：2022-04-19

申请号：US16957101

申请日：2018-12-19

Applicant: IMEC VZW

Inventor： Chengxun Liu ,  Dries Vercruysse ,  Niels Verellen ,  Abdulkadir Yurt

IPC: G01N21/00 ,  G01N15/14 ,  G01N15/10

Abstract: A device (110) for illuminating a particle comprises: a light waveguide (112; 412a, 412b; 512a, 512b) arranged on a substrate (114); an output coupler (118) configured to output a light beam (150; 450a, 450b; 550a, 550b) forming a sheet-like shape having a cross-section which has an extension in a first direction being larger than a size of a particle; and a fluidic channel (116; 416; 516) arranged on the substrate (114) for guiding a flow of particles along a longitudinal direction of the fluidic channel (116; 416; 516); wherein the sheet-like shape of the light beam (150; 450a, 450b; 550a, 550b) is arranged within the fluidic channel (116; 416; 516) and the first direction of the cross-section of the light beam (150; 450a, 450b; 550a, 550b) forms an angle to the longitudinal direction of the fluidic channel (116; 416; 516). A system (100) for imaging the particle comprises the device, an array (130; 430a, 430b; 530) of light-detecting elements (132; 432a, 432b; 532); and a lens (120) to converge light towards the array (130; 430a, 430b; 530) such that each light-detecting element (132; 432a, 432b; 532) detects light originating from a corresponding position in the fluidic channel (116; 416; 516).

公开(公告)号：US11119029B2

公开(公告)日：2021-09-14

申请号：US16335578

申请日：2017-09-18

Applicant: IMEC VZW

Inventor： Dries Vercruysse

IPC: G01N15/00 ,  G01N15/14 ,  G01N21/47 ,  G01N15/10

Abstract: An optical excitation system comprises a substrate (105) comprising at least one delivery means (104), for delivering analytes (109) into at least one region of interest (103), at least one radiation carrier (101) for directing at least one radiation beam from the at least one radiation carrier (101) into the at least one region of interest (103). The substrate (105) includes a thin lens system (120) comprising at least a first thin lens (121), for collimating radiation from the at least one region of interest (103) to a remote detection system (130). A particle sensor and sensing system comprising the excitation system are also provided, for example a modular particle sensor and modular sensing system, wherein the optical excitation system may be single use and disposable.

公开(公告)号：US20210072141A1

公开(公告)日：2021-03-11

申请号：US17102388

申请日：2020-11-23

Applicant: IMEC VZW

Inventor： Dries Vercruysse

IPC: G01N15/14 ,  G01N21/64 ,  G01N21/65 ,  G02B6/30 ,  G02B6/124 ,  F21V8/00

Abstract: A radiation carrier for carrying at least a radiation beam has, on a surface thereof, at least one excitation grating, for directing at least an excitation radiation beam directionally out of the radiation carrier, thereby illuminating a region of interest; and at least one structure for redirecting emission radiation emanating from the region of interest. Further a sensor is provided comprising at least one such radiation carrier and at least one detector, the structure being adapted for redirecting radiation from the region of interest into the at least one detector.

公开(公告)号：US10267998B2

公开(公告)日：2019-04-23

申请号：US15538572

申请日：2015-12-28

Applicant: IMEC VZW

Inventor： Dries Vercruysse ,  Pol Van Dorpe ,  Xavier Rottenberg ,  Tom Claes ,  Richard Stahl

IPC: G02B6/34 ,  G01J3/28 ,  G01N15/14 ,  G02B6/12 ,  G03H1/04

Abstract: Embodiments described herein relate to an imaging device, a method for imaging an object, and a photonic integrated circuit. The imaging device includes at least one photonic integrated circuit. The photonic integrated circuit includes an integrated waveguide for guiding a light signal. The photonic integrated circuit also includes a light coupler optically coupled to the integrated waveguide. The light coupler is adapted for directing the light signal out of a plane of the integrated waveguide as a light beam. The imaging device also includes a microfluidic channel for containing an object immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the imaging device, illumination of the object by the light beam. In addition, the imaging device includes at least one imaging detector positioned for imaging the object illuminated by the light beam.

公开(公告)号：US20170351035A1

公开(公告)日：2017-12-07

申请号：US15538926

申请日：2015-12-28

Applicant: IMEC VZW

Inventor： Xavier Rottenberg ,  Tom Claes ,  Dries Vercruysse

IPC: G02B6/34 ,  G01N15/14 ,  G02B27/22 ,  G01N15/10 ,  G01N15/00

Abstract: Embodiments described herein relate to a light coupler, a photonic integrated circuit, and a method for manufacturing a light coupler. The light coupler is for optically coupling to an integrated waveguide and for out-coupling a light signal propagating in the integrated waveguide into free space. The light coupler includes a plurality of microstructures. The plurality of microstructures is adapted in shape and position to compensate decay of the light signal when propagating in the light coupler. The plurality of microstructures is also adapted in shape and position to provide a power distribution of the light signal when coupled into free space such that the power distribution corresponds to a predetermined target power distribution. Each of the microstructures forms an optical scattering center. The microstructures are positioned on the light coupler in accordance with a non-uniform number density distribution.

公开(公告)号：US20170351034A1

公开(公告)日：2017-12-07

申请号：US15538572

申请日：2015-12-28

Applicant: IMEC VZW

Inventor： Dries Vercruysse ,  Pol Van Dorpe ,  Xavier Rottenberg ,  Tom Claes ,  Richard Stahl

IPC: G02B6/34 ,  G03H1/04 ,  G02B6/12 ,  G01N15/14

CPC classification number: G02B6/34 ,  G01N15/1436 ,  G01N15/1484 ,  G02B6/12 ,  G02B2006/12107 ,  G03H1/0443 ,  G03H2001/0447

Abstract: Embodiments described herein relate to an imaging device, a method for imaging an object, and a photonic integrated circuit. The imaging device includes at least one photonic integrated circuit. The photonic integrated circuit includes an integrated waveguide for guiding a light signal. The photonic integrated circuit also includes a light coupler optically coupled to the integrated waveguide. The light coupler is adapted for directing the light signal out of a plane of the integrated waveguide as a light beam. The imaging device also includes a microfluidic channel for containing an object immersed in a fluid medium. The microfluidic channel is configured to enable, in operation of the imaging device, illumination of the object by the light beam. In addition, the imaging device includes at least one imaging detector positioned for imaging the object illuminated by the light beam.