公开(公告)号：US11609172B2

公开(公告)日：2023-03-21

申请号：US17128093

申请日：2020-12-19

Applicant: IMEC VZW

Inventor： Richard Stahl ,  Abdulkadir Yurt ,  Ziduo Lin ,  Geert Vanmeerbeeck ,  Andy Lambrechts

IPC: G01N15/02 ,  G03H1/08 ,  G03H1/04

Abstract: A device for detecting particles in air; said device comprising: a flow channel configured to allow a flow of air comprising particles through the flow channel; a light source configured to illuminate the particles, such that an interference pattern is formed by interference between light being scattered by the particles and non-scattered light from the light source; an image sensor configured to detect incident light, detect the interference pattern, and to acquire a time-sequence of image frames, each image frame comprising a plurality of pixels, each pixel representing a detected intensity of light; and a frame processor configured to filter information in the time-sequence of image frames, wherein said filtering comprises: identifying pixels of interest in the time-sequence of image frames, said pixels of interest picturing an interference pattern potentially representing a particle in the flow of air, and outputting said identified pixels of interest for performing digital holographic reconstruction.

公开(公告)号：US11175625B2

公开(公告)日：2021-11-16

申请号：US16467612

申请日：2017-12-08

Applicant: IMEC VZW

Inventor： Ziduo Lin ,  Abdulkadir Yurt ,  Richard Stahl ,  Geert Vanmeerbeeck

IPC: G03H1/04 ,  G03H1/00 ,  G03H1/02

Abstract: Example embodiments relate to methods and imaging systems for holographic imaging. One embodiment includes a method for holographic imaging of an object. The method includes driving a laser using a current which is below a threshold current of the laser. The method also includes illuminating the object using illumination light output by the laser. Further, the method includes detecting an interference pattern formed by object light, having interacted with the object, and reference light of the illumination light.

公开(公告)号：US20210162414A1

公开(公告)日：2021-06-03

申请号：US16771025

申请日：2018-12-20

Applicant: IMEC VZW

Inventor： Chengxun Liu ,  Bivragh Majeed ,  Abdulkadir Yurt

IPC: B01L3/00 ,  G01N15/14

Abstract: A microfluidic routing device for routing objects of interest in a microfluidic flow includes a substrate; a first layer provided on the substrate, in which the first layer forms a bottom wall of a microfluidic channel. At least two holes through the first layer form respectively an inlet and an outlet for the microfluidic channel The microfluidic routing device further includes a second layer spaced away from the first layer, in which the second layer forms a top wall of the microfluidic channel. The second layer is configured to transmit an optical signal from the microfluidic channel. The microfluidic routing device includes an actuator for actuating the objects of interest in a sorting junction of the microfluidic channel.

公开(公告)号：US10684589B2

公开(公告)日：2020-06-16

申请号：US15847521

申请日：2017-12-19

Applicant: IMEC vzw

Inventor： Abdulkadir Yurt ,  Geert Vanmeerbeeck ,  Richard Stahl ,  Ziduo Lin

IPC: G03H1/02 ,  G03H1/00 ,  G03H1/04 ,  G03H1/12

Abstract: An apparatus for in-line holographic imaging is disclosed. In one aspect, the apparatus includes at least a first light source and a second light source arranged for illuminating an object arranged in the apparatus with a light beam. The apparatus also includes an image sensor arranged to detect at least a first and a second interference pattern, wherein the first interference pattern is formed when the object is illuminated by the first light source and the second interference pattern is formed when the object is illuminated by the second light source. The first and second interference patterns are formed by diffracted light, being scattered by the object, and undiffracted light of the light beam. The at least first and second light sources are arranged at different angles in relation to the object, and possibly illuminate the object using different wavelengths.

公开(公告)号：US11772095B2

公开(公告)日：2023-10-03

申请号：US16771025

申请日：2018-12-20

Applicant: IMEC VZW

Inventor： Chengxun Liu ,  Bivragh Majeed ,  Abdulkadir Yurt

IPC: B01L3/00 ,  G01N15/14 ,  G01N15/00

CPC classification number: B01L3/502761 ,  B01L3/502707 ,  B01L3/502715 ,  G01N15/1434 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0887 ,  G01N15/1484 ,  G01N2015/0065 ,  G01N2015/149

Abstract: A microfluidic routing device for routing objects of interest in a microfluidic flow includes a substrate; a first layer provided on the substrate, in which the first layer forms a bottom wall of a microfluidic channel. At least two holes through the first layer form respectively an inlet and an outlet for the microfluidic channel The microfluidic routing device further includes a second layer spaced away from the first layer, in which the second layer forms a top wall of the microfluidic channel. The second layer is configured to transmit an optical signal from the microfluidic channel. The microfluidic routing device includes an actuator for actuating the objects of interest in a sorting junction of the microfluidic channel.

公开(公告)号：US11687031B2

公开(公告)日：2023-06-27

申请号：US17128092

申请日：2020-12-19

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven

Inventor： Zhenxiang Luo ,  Abdulkadir Yurt ,  Dries Braeken ,  Liesbet Lagae ,  Richard Stahl

IPC: G03H1/04 ,  G03H1/00 ,  H04N13/254 ,  G02B21/06 ,  G02B21/36

CPC classification number: G03H1/0005 ,  G02B21/06 ,  G02B21/367 ,  G03H1/0443 ,  G03H1/0465 ,  H04N13/254 ,  G03H2001/005 ,  G03H2001/0471 ,  G03H2210/30 ,  G03H2210/55 ,  G03H2222/34 ,  G03H2226/02 ,  G03H2226/11

Abstract: A method for three-dimensional imaging of a sample (302) comprises: receiving (102) interference patterns (208) acquired using light-detecting elements (212), wherein each interference pattern (208) is formed by scattered light from the sample (302) and non-scattered light from a light source (206; 306), wherein the interference patterns (208) are acquired using different angles between the sample (302) and the light source (206; 306); performing digital holographic reconstruction applying an iterative algorithm to change a three-dimensional scattering potential of the sample (302) to improve a difference between the received interference patterns (208) and predicted interference patterns based on the three-dimensional scattering potential; wherein the iterative algorithm reduces a sum of a data fidelity term and a non-differentiable regularization term and wherein the iterative algorithm includes a forward-backward splitting method alternating between forward gradient descent (108) on the data fidelity term and backward gradient descent (110) on the regularization term.

公开(公告)号：US11307133B2

公开(公告)日：2022-04-19

申请号：US16957101

申请日：2018-12-19

Applicant: IMEC VZW

Inventor： Chengxun Liu ,  Dries Vercruysse ,  Niels Verellen ,  Abdulkadir Yurt

IPC: G01N21/00 ,  G01N15/14 ,  G01N15/10

Abstract: A device (110) for illuminating a particle comprises: a light waveguide (112; 412a, 412b; 512a, 512b) arranged on a substrate (114); an output coupler (118) configured to output a light beam (150; 450a, 450b; 550a, 550b) forming a sheet-like shape having a cross-section which has an extension in a first direction being larger than a size of a particle; and a fluidic channel (116; 416; 516) arranged on the substrate (114) for guiding a flow of particles along a longitudinal direction of the fluidic channel (116; 416; 516); wherein the sheet-like shape of the light beam (150; 450a, 450b; 550a, 550b) is arranged within the fluidic channel (116; 416; 516) and the first direction of the cross-section of the light beam (150; 450a, 450b; 550a, 550b) forms an angle to the longitudinal direction of the fluidic channel (116; 416; 516). A system (100) for imaging the particle comprises the device, an array (130; 430a, 430b; 530) of light-detecting elements (132; 432a, 432b; 532); and a lens (120) to converge light towards the array (130; 430a, 430b; 530) such that each light-detecting element (132; 432a, 432b; 532) detects light originating from a corresponding position in the fluidic channel (116; 416; 516).

公开(公告)号：US11841298B2

公开(公告)日：2023-12-12

申请号：US17127972

申请日：2020-12-18

Applicant: IMEC VZW

Inventor： Ziduo Lin ,  Abdulkadir Yurt ,  Richard Stahl ,  Geert Vanmeerbeeck ,  Andy Lambrechts

IPC: G01N1/22 ,  G01N15/14 ,  G01N15/06 ,  G01N1/28 ,  G01N15/02

CPC classification number: G01N1/22 ,  G01N15/0612 ,  G01N15/1463 ,  G01N2001/2223 ,  G01N2001/2276 ,  G01N2001/2833 ,  G01N2015/0233

Abstract: The inventive concept relates to a collector for collecting particles in air and a device for detecting particles in air comprising said collector. Said collector comprises a substrate, which is adapted to enable imaging of the particles, an adhesive layer arranged on a collector side of the substrate, said adhesive layer being formed by an adhesive material. The collector further comprises a protection element, which is configured to protect the adhesive layer before collection of particles. The collector is configured to allow release of protection of the adhesive layer by the protection element to expose an adhesive surface of the adhesive layer to ambient air for collecting particles on the adhesive surface. The collector is further configured for presenting a particle sample carrier having a smooth top surface and a smooth bottom surface for preventing light from being diffusely scattered by the particle sample carrier.

公开(公告)号：US11619574B2

公开(公告)日：2023-04-04

申请号：US17127800

申请日：2020-12-18

Applicant: IMEC VZW

Inventor： Geert Vanmeerbeeck ,  Ziduo Lin ,  Abdulkadir Yurt ,  Richard Stahl

IPC: G01N15/06 ,  G01N15/02 ,  G03H1/08

Abstract: The inventive concept relates to a device for detecting particles in air, said device comprising a receiver for receiving a flow of air comprising particles, a sample carrier, and a particle capturing arrangement. The particle capturing arrangement is configured to separate the particles from the flow of air for and to collect a set of particles on a surface of the sample carrier. The device further comprises a light source configured to illuminate the particles on the sample carrier, such that an interference pattern is formed by interference between light being scattered by the particles and non-scattered light from the light source. The device further comprises an image sensor configured to detect the interference pattern. The device further comprises a cleaner configured for cleaning the surface of the sample carrier for enabling re-use of the surface for collection of a subsequent set of particles.

公开(公告)号：US11307533B2

公开(公告)日：2022-04-19

申请号：US16648987

申请日：2018-09-19

Applicant: IMEC VZW

Inventor： Abdulkadir Yurt ,  Richard Stahl ,  Murali Jayapala ,  Geert Vanmeerbeeck

IPC: G02B21/36 ,  G03H1/04

Abstract: Example embodiments relate to imaging devices for in-line holographic imaging of objects. One embodiment includes an imaging device for in-line holographic imaging of an object. The imaging device includes a set of light sources configured to output light in confined illumination cones. The imaging device also includes an image sensor that includes a set of light-detecting elements. The set of light sources are configured to output light such that the confined illumination cones are arranged side-by-side and illuminate a specific part of the object. The image sensor is arranged such that the light-detecting elements detect a plurality of interference patterns. Each interference pattern is formed by diffracted light from the object originating from a single light source and undiffracted light from the same single light source. At least a subset of the set of light-detecting elements is arranged to detect light relating to not more than one interference pattern.