Imaging apparatus and method for imaging an object

    公开(公告)号:US10883939B2

    公开(公告)日:2021-01-05

    申请号:US16442484

    申请日:2019-06-15

    Applicant: IMEC VZW

    Abstract: An imaging apparatus comprises: (i) an illumination waveguide configured to propagate light by total internal reflection, wherein an evanescent field illuminates an object in close relation to the illumination waveguide; (ii) an array of light-sensitive areas arranged on a common substrate with the illumination waveguide for detecting light from the object; and (iii) a controller configured to control forming of an interference pattern in the illumination waveguide, wherein the interference pattern comprises at least one element of constructive interference for selectively illuminating a portion of the object, the at least one element having a dimension with a size in a range of 100 nm-10 μm; wherein the controller is configured to sequentially change the interference pattern in relation to the object such that different portions are illuminated and light from different portions is sequentially detected.

    Method and device for generating (quasi-) periodic interference patterns

    公开(公告)号:US11555745B2

    公开(公告)日:2023-01-17

    申请号:US17224466

    申请日:2021-04-07

    Abstract: Example embodiments relate to methods and devices for generating (quasi-) periodic interference patterns. One embodiment includes a method for generating an interference pattern using multi-beam interference of electromagnetic radiation. The method includes computing a set of grid points in a complex plane representing a grid with a desired symmetry. The method also includes selecting a radius of a virtual circle. Additionally, the method includes selecting a set of grid points in the complex plane that lies on the virtual circle centered around a virtual center point. Further, the method includes associating an argument of each grid point of the selected set of grid points in the complex plane with a propagation direction of plane waves or quasi plane waves or parallel wave fronts. In addition, the method includes obtaining the interference pattern that is a superposition of the plane waves or quasi plane waves or parallel wave fronts.

    Light excitation and collection device and a method for light excitation and collection

    公开(公告)号:US12066372B2

    公开(公告)日:2024-08-20

    申请号:US17544300

    申请日:2021-12-07

    Applicant: IMEC VZW

    CPC classification number: G01N15/1434 G01N2015/1006

    Abstract: According to an aspect of the present inventive concept there is provided a light excitation and collection device for a micro-fluidic system, comprising:



    a light source configured to generate excitation light;
    a plurality of excitation waveguides, each associated with a flow channel of the micro-fluidic system;
    wherein each excitation waveguide is configured to receive and redirect the excitation light towards the flow channel, such that the excitation light is elastically scattered by a sample in the flow channel forming forward and side scattered light; and
    wherein the light excitation and collection device further comprises:
    at least one forward scattered light collection point; and
    at least one side scattered light collection point; and
    wherein the forward scattered light collected for all excitation waveguides is detected by a first plurality of light sensitive areas and the side scattered light collected for all excitation waveguides is detected by a second plurality of light sensitive areas, the first and the second pluralities of light sensitive areas form different groups of light sensitive areas.

    Multicolor sensor for flow cytometry

    公开(公告)号:US11262239B2

    公开(公告)日:2022-03-01

    申请号:US16715351

    申请日:2019-12-16

    Applicant: IMEC VZW

    Abstract: The present disclosure relates to a spectral sensor for detection of individual light-emitting particles. The sensor is comprising an array of photo-sensitive detectors for detecting light emitted by said individual light-emitting particles and a filter array comprising a plurality of different band-stop filters. The filter array is configured to transmit wavelengths in a detectable wavelength region to the array of photo-sensitive detectors, and wherein each band-stop filter is associated with one or more particular photo-sensitive detectors, and the plurality of different band-stop filters are configured to reflect different wavelength intervals within said detectable wavelength region so that each photo-sensitive detector of the array is configured to detect the wavelengths of the detectable wavelength region other than the reflected wavelength interval of the band-stop filter being associated with the photo-sensitive detector. The sensor is further comprising a processing unit in communication with said array of photo-sensitive detectors and configured for determining a spectral characteristic of an individual light-emitting particle based on the response from said array of photo-sensitive detectors.

    Imaging Apparatus and Method for Imaging an Object

    公开(公告)号:US20190383743A1

    公开(公告)日:2019-12-19

    申请号:US16442484

    申请日:2019-06-15

    Applicant: IMEC VZW

    Abstract: An imaging apparatus comprises: (i) an illumination waveguide configured to propagate light by total internal reflection, wherein an evanescent field illuminates an object in close relation to the illumination waveguide; an array of light-sensitive areas arranged on a common substrate with the illumination waveguide for detecting light from the object; and (iii) a controller configured to control forming of an interference pattern in the illumination waveguide, wherein the interference pattern comprises at least one element of constructive interference for selectively illuminating a portion of the object, the at least one element having a dimension with a size in a range of 100 nm-10 μm; wherein the controller is configured to sequentially change the interference pattern in relation to the object such that different portions are illuminated and light from different portions is sequentially detected.

    Device for illuminating a particle, and a system and a method for particle imaging

    公开(公告)号:US11307133B2

    公开(公告)日:2022-04-19

    申请号:US16957101

    申请日:2018-12-19

    Applicant: IMEC VZW

    Abstract: A device (110) for illuminating a particle comprises: a light waveguide (112; 412a, 412b; 512a, 512b) arranged on a substrate (114); an output coupler (118) configured to output a light beam (150; 450a, 450b; 550a, 550b) forming a sheet-like shape having a cross-section which has an extension in a first direction being larger than a size of a particle; and a fluidic channel (116; 416; 516) arranged on the substrate (114) for guiding a flow of particles along a longitudinal direction of the fluidic channel (116; 416; 516); wherein the sheet-like shape of the light beam (150; 450a, 450b; 550a, 550b) is arranged within the fluidic channel (116; 416; 516) and the first direction of the cross-section of the light beam (150; 450a, 450b; 550a, 550b) forms an angle to the longitudinal direction of the fluidic channel (116; 416; 516). A system (100) for imaging the particle comprises the device, an array (130; 430a, 430b; 530) of light-detecting elements (132; 432a, 432b; 532); and a lens (120) to converge light towards the array (130; 430a, 430b; 530) such that each light-detecting element (132; 432a, 432b; 532) detects light originating from a corresponding position in the fluidic channel (116; 416; 516).

    Method and Device for Generating (Quasi-) Periodic Interference Patterns

    公开(公告)号:US20210325254A1

    公开(公告)日:2021-10-21

    申请号:US17224466

    申请日:2021-04-07

    Abstract: Example embodiments relate to methods and devices for generating (quasi-) periodic interference patterns. One embodiment includes a method for generating an interference pattern using multi-beam interference of electromagnetic radiation. The method includes computing a set of grid points in a complex plane representing a grid with a desired symmetry. The method also includes selecting a radius of a virtual circle. Additionally, the method includes selecting a set of grid points in the complex plane that lies on the virtual circle centered around a virtual center point. Further, the method includes associating an argument of each grid point of the selected set of grid points in the complex plane with a propagation direction of plane waves or quasi plane waves or parallel wave fronts. In addition, the method includes obtaining the interference pattern that is a superposition of the plane waves or quasi plane waves or parallel wave fronts.

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