公开(公告)号：US09146235B2

公开(公告)日：2015-09-29

申请号：US14570675

申请日：2014-12-15

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

Inventor： Pol Van Dorpe ,  Sarp Kerman ,  Peter Peumans ,  Willem Van Roy

IPC: G01N21/64 ,  G01N21/77 ,  G01N33/50 ,  G01N33/543

CPC classification number: G01N33/54373 ,  G01N15/1436 ,  G01N15/1456 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7743 ,  G01N2015/1006 ,  G01N2021/6482 ,  G01N2021/7786

Abstract: An integrated fluorescence detector for detecting fluorescent particles is described. An example integrated fluorescence detector comprises a substrate, the substrate comprising an integrated detection element for detecting fluorescence radiation from fluorescent particles upon excitation of the particles with incident excitation radiation. The integrated fluorescence detector also comprises a sensing layer adapted for accommodating fluorescent particles to be sensed. The integrated fluorescence detector further comprises a photonics crystal layer arranged in between the sensing layer and the substrate, the photonics crystal layer comprising an absorption material designed such that the photonics crystal layer is configured for diffracting incident excitation radiation into a lateral direction in which the photonics crystal layer extends for incident excitation radiation having a wavelength within at least 10 nm of the predetermined excitation wavelength.

Abstract translation: 描述了用于检测荧光颗粒的集成荧光检测器。 示例性的集成荧光检测器包括衬底，该衬底包括用于在用入射激发辐射激发颗粒时检测来自荧光颗粒的荧光辐射的集成检测元件。 集成荧光检测器还包括适于容纳要感测的荧光颗粒的感测层。 集成荧光检测器还包括布置在感测层和衬底之间的光子晶体层，光子晶体层包括设计成使得光子晶体层被配置为将入射激发辐射衍射到横向方向的吸收材料，其中光子 晶体层对于具有在预定激发波长的至少10nm内的波长的入射激发辐射延伸。

公开(公告)号：US20220091117A1

公开(公告)日：2022-03-24

申请号：US17540551

申请日：2021-12-02

Applicant: Imec vzw

Inventor： Willem Van Roy ,  Tim Stakenborg ,  Kris Covens

IPC: G01N33/543 ,  C12Q1/00 ,  C12Q1/6825 ,  G01N33/52

Abstract: A device (1) for sensing an analyte, the device (1) comprises at least a sample inlet (10) for receiving a sample, affinity probes (111) selected to have a preferential binding to the analyte, a transducer (11) sensitive to a characteristic of the analyte and/or a label attached to the analyte, the transducer not being a FET transducer, and a desalting unit (13) for desalting the received sample.

公开(公告)号：US10928305B2

公开(公告)日：2021-02-23

申请号：US15736399

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/17 ,  G01N21/64

Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

公开(公告)号：US20180188156A1

公开(公告)日：2018-07-05

申请号：US15736399

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/17 ,  G01N21/64

CPC classification number: G01N21/1717 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/1731

Abstract: A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

公开(公告)号：US20180156788A1

公开(公告)日：2018-06-07

申请号：US15577076

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Willem Van Roy ,  Tim Stakenborg ,  Kris Covens

IPC: G01N33/543 ,  C12Q1/00 ,  C12Q1/6825 ,  G01N33/52

Abstract: A device (1) for sensing an analyte, the device (1) comprises at least a sample inlet (10) for receiving a sample, affinity probes (111) selected to have a preferential binding to the analyte, a transducer (11) sensitive to a characteristic of the analyte and/or a label attached to the analyte, the transducer not being a FET transducer, and a desalting unit (13) for desalting the received sample.