公开(公告)号：US20240226893A1

公开(公告)日：2024-07-11

申请号：US18559029

申请日：2022-05-12

Applicant: IMEC VZW ,  Janssen Biotech Inc.

Inventor： Peter Peumans ,  Olivier Henry ,  Willem Van Roy ,  Tim Stakenborg ,  Alexander Graham Irwin Tulloch

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/086 ,  B01L2400/088

Abstract: A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological cells. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.

公开(公告)号：US11776564B2

公开(公告)日：2023-10-03

申请号：US17645663

申请日：2021-12-22

Applicant: IMEC vzw

Inventor： Maarten Rosmeulen ,  Arnaud Furnemont ,  Devin Verreck ,  Antonio Arreghini ,  Willem Van Roy ,  Kherim Willems

IPC: G11B3/00

CPC classification number: G11B3/008

Abstract: A memory device including at least one channel and a fluid including particles is provided. In one aspect, the channel includes a least some of the fluid. The memory device may further include an actuator configured to induce a movement of the particles in the channel; and a writing element configured to arrange the particles in a sequence, thereby yielding a sequence of particles in the channel. The particles may include first particles and second particles. The particles may be in a first state or a second state in the channel. In certain aspects, the channel is configured to preserve the sequence of the particles. The memory device may further include a reading element for detecting the sequence of the particles in the channel.

公开(公告)号：US10359363B2

公开(公告)日：2019-07-23

申请号：US15736414

申请日：2016-06-22

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01J3/30 ,  G01N21/64

Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.

公开(公告)号：US20180188176A1

公开(公告)日：2018-07-05

申请号：US15737747

申请日：2016-06-29

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/64 ,  G01N21/17

CPC classification number: G01N21/6452 ,  G01N21/1717 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/1731 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439

Abstract: A sensor device for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector for obtaining an at least one dimensional pattern of measured signals, wherein the detector is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.

公开(公告)号：US20150168392A1

公开(公告)日：2015-06-18

申请号：US14570675

申请日：2014-12-15

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

Inventor： Pol Van Dorpe ,  Sarp Kerman ,  Peter Peumans ,  Willem Van Roy

IPC: G01N33/543 ,  G01N21/64

CPC classification number: G01N33/54373 ,  G01N15/1436 ,  G01N15/1456 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7743 ,  G01N2015/1006 ,  G01N2021/6482 ,  G01N2021/7786

Abstract: An integrated fluorescence detector for detecting fluorescent particles is described. An example integrated fluorescence detector comprises a substrate, the substrate comprising an integrated detection element for detecting fluorescence radiation from fluorescent particles upon excitation of the particles with incident excitation radiation. The integrated fluorescence detector also comprises a sensing layer adapted for accommodating fluorescent particles to be sensed. The integrated fluorescence detector further comprises a photonics crystal layer arranged in between the sensing layer and the substrate, the photonics crystal layer comprising an absorption material designed such that the photonics crystal layer is configured for diffracting incident excitation radiation into a lateral direction in which the photonics crystal layer extends for incident excitation radiation having a wavelength within at least 10 nm of the predetermined excitation wavelength.

Abstract translation: 描述了用于检测荧光颗粒的集成荧光检测器。 示例性的集成荧光检测器包括衬底，该衬底包括用于在用入射激发辐射激发颗粒时检测来自荧光颗粒的荧光辐射的集成检测元件。 集成荧光检测器还包括适于容纳要感测的荧光颗粒的感测层。 集成荧光检测器还包括布置在感测层和衬底之间的光子晶体层，光子晶体层包括设计成使得光子晶体层被配置为将入射激发辐射衍射到横向方向的吸收材料，其中光子 晶体层对于具有在预定激发波长的至少10nm内的波长的入射激发辐射延伸。

公开(公告)号：US11992597B2

公开(公告)日：2024-05-28

申请号：US17728637

申请日：2022-04-25

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Fokko Wieringa ,  Willem Van Roy ,  Patrick van Deursen ,  Lucas Lindeboom

IPC: A61M1/36

CPC classification number: A61M1/3672 ,  A61M2205/70

Abstract: According to an aspect there is provided a method for automatic maintenance of a dialysis system. The dialysis system includes a plurality of filter sections where each filter section includes a blood flow channel, a dialysate flow channel, and a membrane separating the blood flow channel from the dialysate flow channel and having a plurality of pores through which substances are exchanged between a blood flow in the blood flow channel and a dialysate flow in the dialysate flow channel. The method includes determining, for each filter section of the plurality of filter sections, whether a maintenance criterion is fulfilled. The method also includes triggering a maintenance event for a filter section of the plurality of filter sections for which the maintenance criterion is fulfilled. The method also includes executing the maintenance event and optionally administering a thrombolytic agent to the blood flow channel of the filter section.

公开(公告)号：US20230204540A1

公开(公告)日：2023-06-29

申请号：US18068763

申请日：2022-12-20

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

Inventor： Willem Van Roy ,  Chengxun Liu ,  Tinne De Moor

IPC: G01N27/447 ,  B01L3/00

CPC classification number: G01N27/44791 ,  B01L3/502761 ,  G01N27/44713 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0838 ,  B01L2400/0406 ,  B01L2400/0421

Abstract: An electric field gradient focusing device is provided that includes: (i) a fluidic channel having an inlet and an outlet for a fluid, (ii) a first actuator configured to induce a fluid flow in the fluidic channel from the inlet to the outlet via AC electroosmosis, and (iii) a second actuator configured to generate a DC electric field gradient along at least part of the fluidic channel.

公开(公告)号：US20220355013A1

公开(公告)日：2022-11-10

申请号：US17728637

申请日：2022-04-25

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Fokko Wieringa ,  Willem Van Roy ,  Patrick van Deursen ,  Lucas Lindeboom

IPC: A61M1/36

Abstract: According to an aspect there is provided a method for automatic maintenance of a dialysis system. The dialysis system includes a plurality of filter sections where each filter section includes a blood flow channel, a dialysate flow channel, and a membrane separating the blood flow channel from the dialysate flow channel and having a plurality of pores through which substances are exchanged between a blood flow in the blood flow channel and a dialysate flow in the dialysate flow channel. The method includes determining, for each filter section of the plurality of filter sections, whether a maintenance criterion is fulfilled. The method also includes triggering a maintenance event for a filter section of the plurality of filter sections for which the maintenance criterion is fulfilled. The method also includes executing the maintenance event and optionally administering a thrombolytic agent to the blood flow channel of the filter section.

公开(公告)号：US20180172588A1

公开(公告)日：2018-06-21

申请号：US15736457

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/648 ,  G01N2021/6413 ,  G01N2021/6439

Abstract: Sensor devices for quantifying luminescent targets are described herein. An example device comprises a light source for exciting the targets, thus generating luminescence signals and a detector for detecting these signals, resulting in a detected signal which comprises a desired signal originating from the targets and a background signal. It moreover comprises a bleaching device for bleaching of at least part of the sources generating the background signal and a processor configured to trigger the bleaching device to start bleaching, and to trigger the light source for exciting the remaining luminescent targets which are not bleached, and to trigger the detector for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

公开(公告)号：US20180172587A1

公开(公告)日：2018-06-21

申请号：US15736414

申请日：2016-06-22

Applicant: IMEC VZW

Inventor： Peter Peumans ,  Liesbet Lagae ,  Willem Van Roy ,  Tim Stakenborg ,  Pol Van Dorpe

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N21/6456 ,  G01N21/648

Abstract: A sensor device for quantifying luminescent targets. The device comprises a light source for exciting the targets, thus generating luminescence signals, and a detector for detecting these signals of the targets in a cell, resulting in a detected signal comprising a desired signal and a background signal. The detector has a spatial cell resolution and/or a time resolution that is so high that only a limited number of targets will be present in the cell when measuring at low concentration and/or that only a limited number of targets add to the cell in between two measurements. A change in the number of targets in the cell can be observed in the detected signal. The device comprises a processor configured to distinguish the desired and the background signal, and to combine the detected signals of the different cells and/or moments in time, to quantify the targets.