公开(公告)号：US08354508B2

公开(公告)日：2013-01-15

申请号：US12374292

申请日：2007-07-20

申请人： Gundo Diedrich ,  Paul Levi Miller ,  Jackie Papkoff ,  Astrid Strelow

发明人： Gundo Diedrich ,  Paul Levi Miller ,  Jackie Papkoff ,  Astrid Strelow

IPC分类号： C07K16/00 ,  C12P21/08 ,  C12N5/07 ,  C12N5/16

CPC分类号： C07K16/30 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438

摘要： The invention provides isolated anti-Pro115 antibodies that bind to Pro115. The invention also encompasses compositions comprising an anti-Pro115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro115 antibodies. The invention encompasses a method of producing the anti-Pro115 antibodies. Other aspects of the invention are a method of killing an Pro115-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro115 antibody and a method of alleviating or treating an Pro115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro115 antibody to the mammal.

摘要翻译： 本发明提供了与Pro115结合的分离的抗Pro115抗体。 本发明还包括包含抗Pro115抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro115抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro115抗体的细胞。 本发明包括产生抗Pro115抗体的方法。 本发明的其它方面是杀死表达Pro115的癌细胞的方法，包括使癌细胞与抗Pro115抗体接触，以及减轻或治疗哺乳动物中Pro115表达癌症的方法，包括给予治疗有效量 的抗Pro115抗体。

公开(公告)号：US20100143348A1

公开(公告)日：2010-06-10

申请号：US12527918

申请日：2008-02-20

申请人： Jackie Papkoff

发明人： Jackie Papkoff

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/303 ,  C07K2317/73

摘要： The invention encompasses a method of inhibiting growth of tumor cells in vivo, comprising contacting the cells with an anti-Ovr1 15 antibody, or antigen binding fragment thereof. This invention also encompasses a method of alleviating an Ovr1 15-expressing cancer in a mammal, comprising administering a therapeutically effective amount of an anti-Ovr1 15 antibody, or antigen binding fragment thereof, to the mammal.

摘要翻译： 本发明包括抑制体内肿瘤细胞生长的方法，包括使细胞与抗Ovr15抗体或其抗原结合片段接触。 本发明还包括减轻哺乳动物中表达Ovr115的癌症的方法，包括向哺乳动物施用治疗有效量的抗Ovr115抗体或其抗原结合片段。

公开(公告)号：US07964195B2

公开(公告)日：2011-06-21

申请号：US11813528

申请日：2006-01-09

申请人： Jackie Papkoff ,  Kenneth R. Shroyer

发明人： Jackie Papkoff ,  Kenneth R. Shroyer

IPC分类号： A61K39/00 ,  C07K16/00 ,  C12P21/08

CPC分类号： G01N33/574 ,  A61K47/6851 ,  A61K51/1045 ,  A61K2039/505 ,  C07K16/30

摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗头颈部，卵巢，胰腺，肺，子宫内膜或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是通过使癌细胞与抗Ovr110抗体接触来杀死表达Ovr110的癌细胞的方法和通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr110的癌症的方法 抗Ovr110抗体。

公开(公告)号：US20100150907A1

公开(公告)日：2010-06-17

申请号：US12374292

申请日：2007-07-20

申请人： Gundo Diedrich ,  Paul Levi Miller ,  Jackie Papkoff ,  Astrid Strelow

发明人： Gundo Diedrich ,  Paul Levi Miller ,  Jackie Papkoff ,  Astrid Strelow

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/16 ,  A61P35/00

CPC分类号： C07K16/30 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57434 ,  G01N33/57438

摘要： The invention provides isolated anti-Pro115 antibodies that bind to Pro115. The invention also encompasses compositions comprising an anti-Pro115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro115 antibodies. The invention encompasses a method of producing the anti-Pro115 antibodies. Other aspects of the invention are a method of killing an Pro115-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro115 antibody and a method of alleviating or treating an Pro115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro115 antibody to the mammal.

摘要翻译： 本发明提供了与Pro115结合的分离的抗Pro115抗体。 本发明还包括包含抗Pro115抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro115抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro115抗体的细胞。 本发明包括产生抗Pro115抗体的方法。 本发明的其它方面是杀死表达Pro115的癌细胞的方法，包括使癌细胞与抗Pro115抗体接触，以及减轻或治疗哺乳动物中Pro115表达癌症的方法，包括给予治疗有效量 的抗Pro115抗体。

公开(公告)号：US08444971B2

公开(公告)日：2013-05-21

申请号：US12516397

申请日：2007-11-27

申请人： Jackie Papkoff ,  Gundo Diedrich ,  Shu-Hui Liu ,  Agnes Nowakowski

发明人： Jackie Papkoff ,  Gundo Diedrich ,  Shu-Hui Liu ,  Agnes Nowakowski

IPC分类号： A61K39/395

CPC分类号： C07K16/2827 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6823 ,  A61K47/6849 ,  A61K47/6855 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C12N9/96 ,  G01N33/57492 ,  A61K2300/00

摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovr110-expressing cancer cells and alleviating or treating an Ovr110-expressing cancer in a mammal. The anti-Ovr110 antibodies modulate Ovr110 function or internalize upon binding to Ovr110 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovr110 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovr110 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.

摘要翻译： 提供了针对由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达的Ovr110的分离的抗体及其抗原结合片段。 还提供了用于其生产的细胞和方法及其用于杀死表达Ovr110的癌细胞并减轻或治疗哺乳动物中表达Ovr110的癌症的方法。 抗Ovr110抗体在体外和体内与哺乳动物细胞表达的Ovr110结合时调节Ovr110功能或内在化。 还提供了包含抗Ovr110抗体和载体及其制品或试剂盒的组合物。 此外，提供编码抗Ovr110抗体的分离的核酸，含有分离的核酸的表达载体和含有载体的宿主细胞。

公开(公告)号：US08287867B2

公开(公告)日：2012-10-16

申请号：US12527918

申请日：2008-02-20

申请人： Jackie Papkoff

发明人： Jackie Papkoff

IPC分类号： A61K39/395

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K16/303 ,  C07K2317/73

摘要： The invention encompasses a method of inhibiting growth of tumor cells in vivo, comprising contacting the cells with an anti-Ovr115 antibody, or antigen binding fragment thereof. This invention also encompasses a method of alleviating an Ovr115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of an anti-Ovr115 antibody, or antigen binding fragment thereof, to the mammal.

摘要翻译： 本发明包括抑制体内肿瘤细胞生长的方法，包括使细胞与抗Ovr115抗体或其抗原结合片段接触。 本发明还包括减轻哺乳动物中表达Ovr115的癌症的方法，包括向哺乳动物施用治疗有效量的抗Ovr115抗体或其抗原结合片段。

公开(公告)号：US20080199461A1

公开(公告)日：2008-08-21

申请号：US11813528

申请日：2006-01-09

申请人： Jackie Papkoff ,  Kenneth R. Shroyer

发明人： Jackie Papkoff ,  Kenneth R. Shroyer

IPC分类号： A61K39/395 ,  C12N5/02 ,  A61K39/44 ,  G01N33/574

CPC分类号： G01N33/574 ,  A61K47/6851 ,  A61K51/1045 ,  A61K2039/505 ,  C07K16/30

摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗头颈部，卵巢，胰腺，肺，子宫内膜或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制造品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是通过使癌细胞与抗Ovr110抗体接触来杀死表达Ovr110的癌细胞的方法和通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr110的癌症的方法 抗Ovr110抗体。

公开(公告)号：US06475784B1

公开(公告)日：2002-11-05

申请号：US09192012

申请日：1998-11-13

申请人： Jackie Papkoff

发明人： Jackie Papkoff

IPC分类号： C12N510

CPC分类号： C12N9/6435 ,  C07K2319/02 ,  C12Y304/21007

摘要： This invention provides polypeptides having anti-angiogenic activity and nucleic acids that encode these polypeptides. The anti-angiogenic polypeptides include at least kringles 1-3 of plasminogen. The invention also provides methods of using the polypeptides and nucleic acids for inhibiting angiogenesis and other conditions characterized by undesirable endothelial cell proliferation.

摘要翻译： 本发明提供具有抗血管生成活性的多肽和编码这些多肽的核酸。 抗血管生成多肽至少包括纤溶酶原的三环1-3。 本发明还提供了使用多肽和核酸来抑制血管发生和以不良内皮细胞增殖为特征的其它病症的方法。

公开(公告)号：US06462254B1

公开(公告)日：2002-10-08

申请号：US09272068

申请日：1999-03-18

申请人： John Vernachio ,  Jackie Papkoff

发明人： John Vernachio ,  Jackie Papkoff

IPC分类号： C12P2100

CPC分类号： C07K14/005 ,  C07K2319/00 ,  C07K2319/42 ,  C07K2319/43 ,  C07K2319/75 ,  C12N9/6435 ,  C12N15/62 ,  C12N2760/16022 ,  C12Y304/21007

摘要： The present invention provides improved methods for detection of recombinant proteins. The fusion proteins of the invention comprise a capture tag sequence, a detection tag sequence, and polypeptide sequence of interest.

摘要翻译： 本发明提供了用于检测重组蛋白质的改进方法。 本发明的融合蛋白包含捕获标签序列，检测标签序列和感兴趣的多肽序列。