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公开(公告)号：US07964195B2
公开(公告)日：2011-06-21
申请号：US11813528
申请日：2006-01-09
申请人： Jackie Papkoff , Kenneth R. Shroyer
发明人： Jackie Papkoff , Kenneth R. Shroyer
CPC分类号： G01N33/574 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30
摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗头颈部，卵巢，胰腺，肺，子宫内膜或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是通过使癌细胞与抗Ovr110抗体接触来杀死表达Ovr110的癌细胞的方法和通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr110的癌症的方法 抗Ovr110抗体。
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公开(公告)号：US20080199461A1
公开(公告)日：2008-08-21
申请号：US11813528
申请日：2006-01-09
申请人： Jackie Papkoff , Kenneth R. Shroyer
发明人： Jackie Papkoff , Kenneth R. Shroyer
IPC分类号： A61K39/395 , C12N5/02 , A61K39/44 , G01N33/574
CPC分类号： G01N33/574 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K16/30
摘要： The invention provides isolated anti-head and neck, ovarian, pancreatic, lung, endometrial or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell by contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal by administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗头颈部，卵巢，胰腺，肺，子宫内膜或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制造品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是通过使癌细胞与抗Ovr110抗体接触来杀死表达Ovr110的癌细胞的方法和通过施用治疗有效量的哺乳动物缓解或治疗表达Ovr110的癌症的方法 抗Ovr110抗体。
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公开(公告)号：US20100136009A1
公开(公告)日：2010-06-03
申请号：US12516397
申请日：2007-11-27
申请人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
发明人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12N15/13 , C12N15/63 , C12N5/00 , A01K67/027 , G01N33/53 , G01N33/68
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
摘要翻译： 提供了针对由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达的Ovr1010的分离的抗体及其抗原结合片段。 还提供了用于其生产的细胞和方法及其用于杀死表达Ovr10的癌细胞并减轻或治疗哺乳动物中表达Ovr10的癌症的方法。 抗Ovr10抗体调节Ovr10功能或在体外和体内与哺乳动物细胞表达的Ovr1010结合时内化。 还提供了包含抗Ovr10抗体和载体的组合物及其制品或试剂盒。 此外，提供编码抗Ovr10抗体的分离的核酸，含有分离的核酸的表达载体和含有载体的宿主细胞。
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公开(公告)号：US08354508B2
公开(公告)日：2013-01-15
申请号：US12374292
申请日：2007-07-20
CPC分类号： C07K16/30 , C07K16/40 , C07K2317/34 , C07K2317/76 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438
摘要： The invention provides isolated anti-Pro115 antibodies that bind to Pro115. The invention also encompasses compositions comprising an anti-Pro115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro115 antibodies. The invention encompasses a method of producing the anti-Pro115 antibodies. Other aspects of the invention are a method of killing an Pro115-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro115 antibody and a method of alleviating or treating an Pro115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro115 antibody to the mammal.
摘要翻译： 本发明提供了与Pro115结合的分离的抗Pro115抗体。 本发明还包括包含抗Pro115抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro115抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro115抗体的细胞。 本发明包括产生抗Pro115抗体的方法。 本发明的其它方面是杀死表达Pro115的癌细胞的方法，包括使癌细胞与抗Pro115抗体接触，以及减轻或治疗哺乳动物中Pro115表达癌症的方法，包括给予治疗有效量 的抗Pro115抗体。
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公开(公告)号：US20100209438A1
公开(公告)日：2010-08-19
申请号：US12576313
申请日：2009-10-09
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： A61K39/395 , C07K16/30 , A61P35/00 , G01N33/53
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量 的抗Ovr110抗体。
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公开(公告)号：US20100143348A1
公开(公告)日：2010-06-10
申请号：US12527918
申请日：2008-02-20
申请人： Jackie Papkoff
发明人： Jackie Papkoff
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/303 , C07K2317/73
摘要： The invention encompasses a method of inhibiting growth of tumor cells in vivo, comprising contacting the cells with an anti-Ovr1 15 antibody, or antigen binding fragment thereof. This invention also encompasses a method of alleviating an Ovr1 15-expressing cancer in a mammal, comprising administering a therapeutically effective amount of an anti-Ovr1 15 antibody, or antigen binding fragment thereof, to the mammal.
摘要翻译： 本发明包括抑制体内肿瘤细胞生长的方法，包括使细胞与抗Ovr15抗体或其抗原结合片段接触。 本发明还包括减轻哺乳动物中表达Ovr115的癌症的方法，包括向哺乳动物施用治疗有效量的抗Ovr115抗体或其抗原结合片段。
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公开(公告)号：US20090220424A1
公开(公告)日：2009-09-03
申请号：US12354047
申请日：2009-01-15
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Weniu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： A61K49/00 , C07K16/00 , C12N5/00 , C12N5/02 , G01N33/567 , A61K39/395 , C07H21/02
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中表达Pro104的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US08080650B2
公开(公告)日：2011-12-20
申请号：US12354047
申请日：2009-01-15
申请人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
发明人： Jackie Papkoff , Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Muriel Kmet , Jianwen Tang
IPC分类号： C07H21/04
CPC分类号： G01N33/57415 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6869 , A61K49/0032 , A61K49/0058 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/77 , G01N33/57449 , G01N2500/00
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Pro104) antibodies that bind to Pro104 on a mammalian cell in vivo. The invention also encompasses compositions comprising an anti-Pro104 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro104 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro104 antibodies. The invention encompasses a method of producing the anti-Pro104 antibodies. Other aspects of the invention are a method of killing a Pro104-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro104 antibody and a method of alleviating or treating a Pro104-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro104 antibody to the mammal.
摘要翻译： 本发明提供在体内在哺乳动物细胞上结合Pro104的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Pro104）抗体。 本发明还包括包含抗Pro104抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro104抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro104抗体的细胞。 本发明包括产生抗Pro104抗体的方法。 本发明的其它方面是杀死表达Pro104的癌细胞的方法，包括使癌细胞与抗Pro104抗体接触，以及减轻或治疗哺乳动物中表达Pro104的癌症的方法，包括给予治疗有效量 的抗Pro104抗体。
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公开(公告)号：US20100150907A1
公开(公告)日：2010-06-17
申请号：US12374292
申请日：2007-07-20
IPC分类号： A61K39/395 , C07K16/18 , C12N5/16 , A61P35/00
CPC分类号： C07K16/30 , C07K16/40 , C07K2317/34 , C07K2317/76 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N33/57438
摘要： The invention provides isolated anti-Pro115 antibodies that bind to Pro115. The invention also encompasses compositions comprising an anti-Pro115 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Pro115 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Pro115 antibodies. The invention encompasses a method of producing the anti-Pro115 antibodies. Other aspects of the invention are a method of killing an Pro115-expressing cancer cell, comprising contacting the cancer cell with an anti-Pro115 antibody and a method of alleviating or treating an Pro115-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Pro115 antibody to the mammal.
摘要翻译： 本发明提供了与Pro115结合的分离的抗Pro115抗体。 本发明还包括包含抗Pro115抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Pro115抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Pro115抗体的细胞。 本发明包括产生抗Pro115抗体的方法。 本发明的其它方面是杀死表达Pro115的癌细胞的方法，包括使癌细胞与抗Pro115抗体接触，以及减轻或治疗哺乳动物中Pro115表达癌症的方法，包括给予治疗有效量 的抗Pro115抗体。
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公开(公告)号：US20070178101A1
公开(公告)日：2007-08-02
申请号：US10557331
申请日：2004-05-10
申请人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
发明人： Glenn Pilkington , Gilbert-Andre Keller , Wenlu Li , Laura Corral , Iris Simon , Jackie Papkoff
IPC分类号： A61K39/395 , C12N5/06 , C12N1/21 , C07K16/30 , C07K16/46
CPC分类号： C07K16/3069 , A61K47/6855 , A61K47/6869 , C07K16/3015 , C07K2317/73 , C07K2317/77 , C07K2317/92
摘要： The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
摘要翻译： 本发明提供了在哺乳动物体内与Ovr110结合时内化的分离的抗卵巢，胰腺，肺或乳腺癌抗原（Ovr110）抗体。 本发明还包括包含抗Ovr110抗体和载体的组合物。 这些组合物可以在制品或试剂盒中提供。 本发明的另一方面是编码抗Ovr110抗体的分离的核酸，以及包含分离的核酸的表达载体。 还提供产生抗Ovr110抗体的细胞。 本发明包括产生抗Ovr110抗体的方法。 本发明的其它方面是杀死表达Ovr110的癌细胞的方法，包括使癌细胞与抗Ovr110抗体接触，以及减轻或治疗哺乳动物中表达Ovr110的癌症的方法，包括给予治疗有效量 的抗Ovr110抗体。
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