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公开(公告)号：US06462254B1
公开(公告)日：2002-10-08
申请号：US09272068
申请日：1999-03-18
申请人： John Vernachio , Jackie Papkoff
发明人： John Vernachio , Jackie Papkoff
IPC分类号： C12P2100
CPC分类号： C07K14/005 , C07K2319/00 , C07K2319/42 , C07K2319/43 , C07K2319/75 , C12N9/6435 , C12N15/62 , C12N2760/16022 , C12Y304/21007
摘要： The present invention provides improved methods for detection of recombinant proteins. The fusion proteins of the invention comprise a capture tag sequence, a detection tag sequence, and polypeptide sequence of interest.
摘要翻译： 本发明提供了用于检测重组蛋白质的改进方法。 本发明的融合蛋白包含捕获标签序列，检测标签序列和感兴趣的多肽序列。
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2.发明授权公开(公告)号：US09351989B2
公开(公告)日：2016-05-31
申请号：US13988354
申请日：2011-12-29
IPC分类号： A61K38/21 , A01N43/04 , A61K31/70 , C07H19/20 , C07H19/052 , A61K31/7076 , C07D473/16 , C07D473/18 , C07D473/24 , A61K31/708 , C07H19/067 , A61K45/06 , C07H17/02 , A61K31/7056
CPC分类号： A61K31/7076 , A61K31/7056 , A61K31/708 , A61K38/21 , A61K45/06 , C07D473/16 , C07D473/18 , C07D473/24 , C07H17/02 , C07H19/067 , A61L2300/00 , A61K2300/00
摘要： This invention is directed to phosphoroamidate and phosphorodiamidate derivatives including the compounds of formula (I) having the structure wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. These compounds and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals infected by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV). The compounds of this invention may be prepared by various methods known in the art of organic chemistry in general and nucleoside and nucleotide analog synthesis in particular.
摘要翻译： 本发明涉及包括其中U，V，W，Z，R 1，X 1，X 2和Y在本文中定义的结构的式（I）化合物的酰亚氨酸酯和二亚磷酸衍生物衍生物。 含有这些化合物的这些化合物和药物组合物可用于治疗由病毒特异性丙型肝炎病毒（HCV）的黄病毒科病毒感染的哺乳动物中的病毒感染。 本发明的化合物可以通过有机化学领域中已知的各种方法制备，特别是核苷和核苷酸类似物的合成。
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3.发明授权Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections 失效用于治疗病毒感染的鸟苷核苷化合物的氨基磷酸衍生物公开(公告)号：US08759318B2
公开(公告)日：2014-06-24
申请号：US13143098
申请日：2010-01-11
申请人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigan , John Vernachio , Mohamed Aljarah , Arnaud Gilles
发明人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigan , John Vernachio , Mohamed Aljarah , Arnaud Gilles
CPC分类号： C07H19/207 , C07H19/167
摘要： Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
摘要翻译： 提供了衍生自具有增强的治疗效力的鸟嘌呤碱基的氨基磷酸酯化合物，并且这些化合物在治疗病毒感染方面尤其具有增强的效力，例如丙型肝炎病毒。 还提供了药物组合物，制备化合物的方法，以及使用该化合物和组合物治疗病毒感染的方法。
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4.发明申请Sdr proteins from staphylococcus capitis and their use in preventing and treating infections 审中-公开来自葡萄球菌属capitis的Sdr蛋白及其在预防和治疗感染中的应用公开(公告)号：US20070026011A1
公开(公告)日：2007-02-01
申请号：US10558479
申请日：2004-06-01
申请人： Yule Liu , John Vernachio , Joseph Patti
发明人： Yule Liu , John Vernachio , Joseph Patti
IPC分类号： A61K39/085 , C07H21/04 , C12N15/74 , C12N1/21 , C07K14/31
CPC分类号： C07K14/31 , A61K39/00 , A61K2039/505
摘要： An isolated and/or purified Sdr surface protein from S. capitis and nucleic acids encoding them are provided which includes the SdrX protein which possesses collagen binding activites and the SdrZL protein which possesses SdrZ-like properties. The Sdr surface proteins from S. capitis can be used in pharmaceutical compositions to treat and prevent S. capitis infectionm and can also be used in vaccines and to raise antibodies which can treat or prevent such infections. Because the SdrX protein has been shown to have collagen binding abilities, antibodies to SdrX will have the ability to inhibit or prevent the ability of S. capitis to bind to collagen.
摘要翻译： 提供了一种分离的和/或纯化的来自头孢菌素的Sdr表面蛋白和编码它们的核酸，其包括具有胶原结合活性的SdrX蛋白和具有SdrZ样特性的SdrZL蛋白。 来自头孢菌素的Sdr表面蛋白质可用于药物组合物中以治疗和预防头孢菌素感染，并且还可用于疫苗和产生可治疗或预防这种感染的抗体。 由于SdrX蛋白已被证明具有胶原结合能力，因此对SdrX的抗体将具有抑制或预防人头颈炎结合胶原蛋白的能力的能力。
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5.发明申请Method of inhibiting Candida-related infections using donor selected or donor stimulated immunoglobulin compositions 审中-公开使用供体选择或供体刺激的免疫球蛋白组合物抑制念珠菌相关感染的方法公开(公告)号：US20050287146A1
公开(公告)日：2005-12-29
申请号：US11016564
申请日：2004-12-20
申请人： Joseph Patti , John Vernachio , Yule Liu , Magnus Hook , Maria Bowden , Jenny Singvall
发明人： Joseph Patti , John Vernachio , Yule Liu , Magnus Hook , Maria Bowden , Jenny Singvall
IPC分类号： A61K39/00 , A61K39/395 , A61K39/40 , C07K16/12 , C07K16/14 , G01N33/569
CPC分类号： C07K16/1271 , A61K2039/505 , C07K16/14 , C07K2317/21 , G01N33/569 , G01N2333/40
摘要： A method for treating or preventing infections from yeast of the Candida species is provided wherein an immunoglobulin composition containing high titers of antibodies to staphylococcal adhesins ClfA and SdrG is administered in an amount effective to inhibit the growth and progression of Candidial infections. The compositions and methods of the present invention are advantageous in that they can be used to treat both staphylococcal and Candidial infections at the same time, and they are particularly effective in treating or preventing late-onset sepsis in neonates.
摘要翻译： 提供了治疗或预防念珠菌种酵母感染的方法，其中以有效抑制候选感染的生长和进展的量施用含有高葡萄球菌粘附素ClfA和SdrG抗体滴度的免疫球蛋白组合物。 本发明的组合物和方法的优点在于它们可用于同时治疗葡萄球菌和候选感染，并且它们在治疗或预防新生儿迟发性败血症方面特别有效。
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6.发明申请SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS 有权用于治疗病毒感染的替代的嘌呤核苷酸，磷酸酰胺和磷酸酰胺衍生物公开(公告)号：US20140140955A1
公开(公告)日：2014-05-22
申请号：US13988354
申请日：2011-12-29
IPC分类号： A61K31/7076 , A61K45/06 , C07H17/02
CPC分类号： A61K31/7076 , A61K31/7056 , A61K31/708 , A61K38/21 , A61K45/06 , C07D473/16 , C07D473/18 , C07D473/24 , C07H17/02 , C07H19/067 , A61L2300/00 , A61K2300/00
摘要： This invention is directed to novel compounds of formula (I) having the structure (I) wherein U, V, W, Z, R1, X1, X2, and Y are defined herein. The compounds of formula (I) and pharmaceutical compositions containing these compounds are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses, in particular hepatitis C virus (HCV).
摘要翻译： 本发明涉及具有结构（I）的式（I）化合物，其中U，V，W，Z，R 1，X 1，X 2和Y如本文所定义。 式（I）化合物和含有这些化合物的药物组合物可用于治疗由至少部分由病毒特异性丙型肝炎病毒（HCV）的黄病毒科病毒介导的哺乳动物的病毒感染。
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7.发明申请Phosphoramidate Derivatives of Guanosine Nucleoside Compunds for Treatment of Viral Infections 失效鸟苷核苷的氨基磷酸衍生物用于治疗病毒感染公开(公告)号：US20120052046A1
公开(公告)日：2012-03-01
申请号：US13143098
申请日：2010-01-11
申请人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigam , John Vernachio , Mohamed Aljarah , Arnaud Gilles
发明人： Stanley Chamberlain , Jeff Hutchins , Karolina Madela , Christopher McGuigam , John Vernachio , Mohamed Aljarah , Arnaud Gilles
IPC分类号： A61K38/21 , A61K31/7076 , C07H19/167 , A61P31/14 , A61K38/16 , A61K31/7105 , C07H1/06 , C07H19/20 , C07H19/16
CPC分类号： C07H19/207 , C07H19/167
摘要： Phosphoramidate compounds derived from guanine bases having enhanced therapeutic potency are provided, and these compounds in particular have enhanced potency with respect to treatment of viral infections, such as hepatitis C virus. Pharmaceutical compositions, methods of preparing the compounds, and methods of using the compounds and compositions to treat viral infections are also provided.
摘要翻译： 提供了衍生自具有增强的治疗效力的鸟嘌呤碱基的氨基磷酸酯化合物，并且这些化合物在治疗病毒感染方面尤其具有增强的效力，例如丙型肝炎病毒。 还提供了药物组合物，制备化合物的方法，以及使用该化合物和组合物治疗病毒感染的方法。
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