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11.发明授权公开(公告)号：US07682788B2
公开(公告)日：2010-03-23
申请号：US10884536
申请日：2004-07-02
申请人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
发明人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
IPC分类号： C12Q1/68
CPC分类号： G01N33/54346 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/54366 , G01N33/5438 , G01N33/552 , G01N33/553 , G01N33/582 , G01N33/587 , G01N2458/30 , C12Q2563/149 , C12Q2563/113 , C12Q2537/125
摘要： A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.
摘要翻译： 提出了一种用于进行电化学发光测定的方法和装置。 在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。 在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及 （c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。
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公开(公告)号：US6066448A
公开(公告)日：2000-05-23
申请号：US611804
申请日：1996-03-06
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon LeLand
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Liang-Hong Guo , Alan Fischer , Jon LeLand
IPC分类号： C12M1/00 , C12Q1/68 , G01N21/66 , G01N21/76 , G01N21/78 , G01N33/543 , G01N33/548 , G01N33/566 , G01N33/58 , G01N37/00
CPC分类号： G01N21/66 , G01N21/76 , G01N33/5438 , G01N33/582 , B82Y30/00 , Y10S436/806 , Y10S977/957
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces which are electronically excited for use in electrochemiluminescence based tests. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use in flat panel displays and multiply specific testing procedures.
摘要翻译： 提供材料和方法用于产生电子激发用于基于电化学发光的测试的图案化多阵列多特异性表面。 提供材料和方法用于化学和/或物理控制导电域和试剂沉积，用于平板显示器和多种特定测试程序。
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公开(公告)号：US06413783B1
公开(公告)日：2002-07-02
申请号：US08932985
申请日：1997-09-18
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
IPC分类号： G01N33543
CPC分类号： G01N33/5438 , G01N21/76 , G01N33/5302 , Y10S435/808 , Y10S436/805
摘要： An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
摘要翻译： 测定装置包括具有工作电极的单元和在该单元结构上耦合以超声处理单元的内容的超声处理设备。
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公开(公告)号：US07008796B2
公开(公告)日：2006-03-07
申请号：US10152234
申请日：2002-05-21
申请人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
发明人： Jacob N. Wohlstadter , James Wilbur , George Sigal , Mark Martin , Alan Fischer , Larry R. Helms , Ramin Darvari
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , G01N21/76 , G01N33/5302 , Y10S435/808 , Y10S436/805
摘要： An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
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公开(公告)号：US20120190591A1
公开(公告)日：2012-07-26
申请号：US13439309
申请日：2012-04-04
申请人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
IPC分类号： C40B60/12
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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公开(公告)号：US06517777B2
公开(公告)日：2003-02-11
申请号：US09761528
申请日：2001-01-16
IPC分类号： G01N2164
摘要： Apparatus for the conduct of electrochemiluminescence measurements includes an ECL chamber having a transparent window defining one wall of the chamber and a photodetector mounted closely adjacent thereto. An assay fluid is subject to a magnetic field and is electrically energized. Electrochemiluminescence induced in the fluid is measured by the photodetector.
摘要翻译： 用于进行电化学发光测量的装置包括ECL室，其具有限定室的一个壁的透明窗口和与其紧邻地安装的光电检测器。 测定流体经受磁场并且被电通电。 通过光电检测器测量在流体中诱导的电化学发光。
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公开(公告)号：US06200531B1
公开(公告)日：2001-03-13
申请号：US09076325
申请日：1998-05-11
IPC分类号： G01N2164
摘要： Apparatus for the conduct of electrochemiluminescence measurements includes an ECL chamber having a transparent window defining one wall of the chamber and a photodetector mounted closely adjacent thereto. An assay fluid is subject to a magnetic field and is electrically energized. Electrochemiluminescence induced in the fluid is measured by the photodetector.
摘要翻译： 用于进行电化学发光测量的装置包括ECL室，其具有限定室的一个壁的透明窗口和与其紧邻地安装的光电检测器。 测定流体经受磁场并且被电通电。 通过光电检测器测量在流体中诱导的电化学发光。
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公开(公告)号：US09664613B2
公开(公告)日：2017-05-30
申请号：US12944218
申请日：2010-11-11
申请人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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19.发明授权公开(公告)号：US08790578B2
公开(公告)日：2014-07-29
申请号：US13439309
申请日：2012-04-04
申请人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
IPC分类号： G01N27/00
CPC分类号： G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有集成电极的测定模块进行发光测试测量，所述测量模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：USD516221S1
公开(公告)日：2006-02-28
申请号：US29167119
申请日：2002-09-09
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