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公开(公告)号:US5968092A
公开(公告)日:1999-10-19
申请号:US083341
申请日:1998-05-22
CPC分类号: A61F2/82 , A61F2/88 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901
摘要: A method for making a biodegradable stent for insertion into a lumen, the method involves the casting of a film including a matrix of collagen IV and laminin, drying the film, casting a film containing polylactic acid onto the first dried film to form stent material, drying the material formed and forming the biodegradable material into a stent.
摘要翻译: 一种生物可降解支架用于插入内腔的方法,该方法包括将包含胶原IV和层粘连蛋白基质的膜流延,干燥该膜,将含有聚乳酸的膜浇铸到第一干燥膜上以形成支架材料, 将形成的材料干燥并将可生物降解材料形成支架。
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公开(公告)号:US07806925B2
公开(公告)日:2010-10-05
申请号:US11041027
申请日:2005-01-21
IPC分类号: A61F2/06
CPC分类号: A61F2/82 , A61F2/88 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901 , C08L67/04
摘要: A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
摘要翻译: 支架包括用于插入活体血管内腔的大体管状形状的主体。 管状主体包括基本上可生物降解的基质,其具有包围基质内的空隙的胶原IV和层粘连蛋白。 管状主体还包括与基质接触以增强基质的可生物降解的强化材料。 管状主体基本上被药物饱和。
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公开(公告)号:US06270515B1
公开(公告)日:2001-08-07
申请号:US08805633
申请日:1997-02-26
IPC分类号: A61B1708
CPC分类号: A61L31/16 , A61B17/0057 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/00615 , A61L31/04 , A61L31/044 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , A61L2300/412 , A61L2300/414 , C08L85/02 , C08L67/04 , C08L75/04
摘要: A device for closing off a septal defect including a polymeric self-hardening material in a specific conformation which is delivered by a catheter means to the area of defect either directly on the cardiac tissue or into a balloon which spans both surfaces of the defect, and hardened in-situ by change in pH or ionic concentration, organic solvents, by permeation of a secondary material capable of precipitation, or by exposure to heat, light or laser energy. In blood, the device may be hardened through photopolymerization or a cooperative effect of coagulation, precipitation or ionization. The device can be made of biodegradable material impregnated with growth factors, mitogenic factors or other determinants which can improve tissue growth such that tissue ingrowth can occur over a period of time. The catheter itself may be an ultrasonic imaging catheter.
摘要翻译: 一种用于闭合中隔缺损的装置,其包括特定构象中的聚合物自硬化材料,其通过导管装置直接在心脏组织或跨越缺损的两个表面的气囊中传递到缺陷区域;以及 通过pH或离子浓度的变化,有机溶剂,能够沉淀的二次材料的渗透,或通过暴露于热,光或激光能量而原位硬化。 在血液中,可以通过光聚合或凝结,沉淀或离子化的协同作用使装置硬化。 该装置可以由浸有生长因子,促有丝分裂因子或其他决定因素的可生物降解材料制成,其可以改善组织生长,使得组织向内生长可以在一段时间内发生。 导管本身可以是超声成像导管。
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公开(公告)号:US07499757B2
公开(公告)日:2009-03-03
申请号:US10971577
申请日:2004-10-22
申请人: M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
发明人: M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
IPC分类号: A61N1/05
CPC分类号: A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要: A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.
摘要翻译: 用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。 该系统包括引线体,由生物可吸收或可生物降解的聚合物形成的锚固机构,用于接合患者心脏的表面,以及形成在引线体的一部分上的表面特征,用于促进在引线体的所述部分周围形成瘢痕组织 。
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公开(公告)号:US5634936A
公开(公告)日:1997-06-03
申请号:US383824
申请日:1995-02-06
CPC分类号: A61L31/16 , A61B17/0057 , A61L31/04 , A61L31/044 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00601 , A61B2017/00606 , A61B2017/00615 , A61L2300/412 , A61L2300/414
摘要: A device for closing off a septal defect including a polymeric self-hardening material in a specific conformation which is delivered by a catheter device to the area of defect either directly on the cardiac tissue or into a balloon which spans both surfaces of the defect, and hardened in-situ by change in pH or ionic concentration, organic solvents, by permeation of a secondary material capable of precipitation, or by exposure to heat, light or laser energy. In blood, the device may be hardened through photopolymerization or a cooperative effect of coagulation, precipitation or ionization. The device can be made of biodegradable material impregnated with growth factors, mitogenic factors or other determinants which can improve tissue growth such that tissue ingrowth can occur over a period of time. The catheter itself may be an ultrasonic imaging catheter.
摘要翻译: 一种用于闭合中隔缺损的装置,其包括特定构象的聚合物自硬化材料,其通过导管装置直接在心脏组织或横跨缺损的两个表面的气球中传送到缺陷区域;以及 通过pH或离子浓度的变化,有机溶剂,能够沉淀的二次材料的渗透,或通过暴露于热,光或激光能量而原位硬化。 在血液中,可以通过光聚合或凝结,沉淀或离子化的协同作用使装置硬化。 该装置可以由浸有生长因子,促有丝分裂因子或其他决定因素的可生物降解材料制成,其可以改善组织生长,使得组织向内生长可以在一段时间内发生。 导管本身可以是超声成像导管。
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公开(公告)号:US5769883A
公开(公告)日:1998-06-23
申请号:US561374
申请日:1995-11-21
CPC分类号: A61F2/82 , A61F2/88 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901
摘要: A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
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公开(公告)号:US5500013A
公开(公告)日:1996-03-19
申请号:US372822
申请日:1995-01-13
CPC分类号: A61F2/82 , A61F2/88 , A61L31/041 , A61L31/044 , A61L31/047 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61F2250/0068 , A61L2300/42 , A61L2300/604 , A61L2300/606 , A61L2300/622 , Y10S623/901
摘要: A stent includes a main body of a generally tubular shape for insertion into a lumen of a vessel of a living being. The tubular main body includes a substantially biodegradable matrix having collagen IV and laminin that enclose voids within the matrix. The tubular main body also includes a biodegradable strengthening material in contact with the matrix to strengthen the matrix. The tubular main body is essentially saturated with drugs.
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公开(公告)号:US5464450A
公开(公告)日:1995-11-07
申请号:US215206
申请日:1994-03-21
IPC分类号: A61F2/00 , A61F2/02 , A61F2/82 , A61F2/88 , A61L31/14 , A61L31/16 , A61F2/06 , A61F2/04 , A61M29/02
CPC分类号: A61F2/82 , A61F2/88 , A61L31/148 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2210/0023 , A61F2250/0067 , A61L2300/604
摘要: A stent made of biodegradable material includes a drug that is released at a rate controlled by the rate of degradation of the biodegradable material. The stent includes a main body of a generally tubular shape. The main body may further include a plurality of apertures extending therethrough and a slot defined by opposing edges which permits insertion and positioning of the stent.
摘要翻译: 由可生物降解材料制成的支架包括以可生物降解材料的降解速率控制的速率释放的药物。 支架包括大体管状的主体。 主体还可以包括延伸穿过其中的多个孔和由允许插入和定位支架的相对边缘限定的狭槽。
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公开(公告)号:US07499759B2
公开(公告)日:2009-03-03
申请号:US10972298
申请日:2004-10-22
申请人: M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
发明人: M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
IPC分类号: A61N1/05
CPC分类号: A61N1/0587 , A61N2001/0578
摘要: The present invention is a myocardial lead attachment system for securing a lead within the myocardium. The attachment system includes an anchor configured to engage the heart, a tether coupled to the anchor and a lead body. The lead body has a proximal end, a distal end, a lumen for accepting the tether and a lock housing in the lumen. A lock structure is on the tether and mates with the lock housing and restrains motion of the lead with respect to the tether in either of a proximal or a distal direction.
摘要翻译: 本发明是用于将铅固定在心肌内的心肌引导附着系统。 附接系统包括构造成接合心脏的锚,连接到锚固体的系绳和引导体。 引线体具有近端,远端,用于接纳系绳的内腔和在内腔中的锁定壳体。 锁定结构位于系绳上并且与锁定壳体配合并且在近端或远端方向中抑制引线相对于系绳的运动。
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公开(公告)号:US07418298B2
公开(公告)日:2008-08-26
申请号:US10971549
申请日:2004-10-22
申请人: Jason Alan Shiroff , Ronald W. Heil, Jr. , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme, II , David B. Yingling
发明人: Jason Alan Shiroff , Ronald W. Heil, Jr. , Peter T. Kelley , M. Sean Coe , Randy W. Westlund , Donald F. Palme, II , David B. Yingling
IPC分类号: A61N1/05
CPC分类号: A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要: The present invention is a myocardial lead attachment system and method for securing a distal end of a lead within the myocardium of a patient's heart. The system includes an anchor, a tether coupled at a distal end to the anchor and a lead body. The lead body has a proximal end, a distal end, and a lumen extending therethrough for receiving the tether. A fixation mechanism is at the distal end of the lead body, and is adapted to collapse to a first configuration during implantation and deploy to a second configuration after implantation.
摘要翻译: 本发明是用于将铅的远端固定在患者心脏的心肌内的心肌引导附着系统和方法。 该系统包括锚固件,在远端连接到锚固件的系绳和引线主体。 引线本体具有近端,远端和延伸穿过其中的内腔,用于接收系绳。 固定机构位于引线主体的远端,并且适于在植入期间折叠成第一构型并且在植入之后部署到第二构造。
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