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公开(公告)号：US07589059B2
公开(公告)日：2009-09-15
申请号：US10628792
申请日：2003-07-28
申请人： Jon A. Wolff , Vladimir G. Budker , Hans Herweijer , James E. Hagstrom , Sean D. Monahan , Julia Hegge , Vladimir Subbotin
发明人： Jon A. Wolff , Vladimir G. Budker , Hans Herweijer , James E. Hagstrom , Sean D. Monahan , Julia Hegge , Vladimir Subbotin
CPC分类号： A61K9/0019 , A61K38/00 , A61K48/0075 , C12N15/87 , C12N2799/022
摘要： Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate transiently increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the molecule to the cell.
摘要翻译： 公开了一种使用血管内施用途径向血管外哺乳动物细胞体内递送分子或复合物的系统。 将分子或复合物插入哺乳动物脉管系统的注射溶液中。 以适当的速率插入注射溶液瞬时增加组织中血管外流体的体积，从而便于将分子递送至细胞。
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公开(公告)号：US07144869B2
公开(公告)日：2006-12-05
申请号：US10310398
申请日：2002-12-05
CPC分类号： A61K48/0075
摘要： Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.
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公开(公告)号：US20060115462A1
公开(公告)日：2006-06-01
申请号：US11286719
申请日：2005-11-23
申请人： Vladimir Subbotin , Julia Hegge
发明人： Vladimir Subbotin , Julia Hegge
IPC分类号： A61K48/00
CPC分类号： A61K48/0083 , A61K38/1875 , A61K48/0075
摘要： An method is described that enables in vivo delivery of polynucleotides to cells of a mammalian bone limb. The method involves the injection of polynucleotides in a large volume into the lumen of the bone.
摘要翻译： 描述了能够将多核苷酸体内递送到哺乳动物骨肢的细胞的方法。 该方法包括将大量体内的多核苷酸注射到骨的内腔中。
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14.发明授权Devices and processes for distribution of genetic material to mammalian limb 失效将遗传物质分配给哺乳动物肢体的装置和方法公开(公告)号：US07214369B2
公开(公告)日：2007-05-08
申请号：US10429478
申请日：2003-05-05
CPC分类号： A61K48/0075 , A61K38/1825 , A61K38/1866
摘要： A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution is enhanced by combining injection of a solution containing the polynucleotide with the use of an externally applied cuff.
摘要翻译： 描述了将治疗性多核苷酸递送至患有或可能患有缺血的肢体肌肉组织的方法。 将多核苷酸插入哺乳动物肢体血管如动脉。 通过将含有多核苷酸的溶液的注入与使用外部应用的袖带组合来提高递送效率和分布。
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公开(公告)号：US07435723B2
公开(公告)日：2008-10-14
申请号：US10680742
申请日：2003-10-06
申请人： James E. Hagstrom , Mark Noble , Julia Hegge , Vladimir G. Budker
发明人： James E. Hagstrom , Mark Noble , Julia Hegge , Vladimir G. Budker
CPC分类号： C07H21/00 , A61K47/62 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.
摘要翻译： 公开了一种使用血管内施用途径向哺乳动物前列腺细胞体内递送多核苷酸的系统。 将多核苷酸插入到哺乳动物脉管系统的注射溶液中。 以适当的速率插入注射溶液会增加组织中血管外液体的体积，从而便于将多核苷酸递送至细胞。
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