摘要:
The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 and Z2 areas defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要:
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein.
摘要:
A plurality of switching modules (102) are interconnected via an optical link (104) to form a switching system (100). Different wavelengths of the optical link (104) are used to selectively direct communications between the plurality of switching modules. Wavelengths have a fixed or variable allocation to communications between switching modules. Wavelengths may be time multiplexed or further subdivided by fractional wavelengths. Communications between switching modules are accomplished by allocating wavelengths in the optical link to transmitting and selectively receiving the communications on the allocated wavelengths.
摘要:
Apparatus and a method for interfacing between the Internet and the Telephone Network. A time slot interchange is enhanced by the addition of a supplementary memory for storing data for accumulating Internet packets. When a packet has been accumulated, the appropriate header is inserted into the packet under the control of a routing processor, and the packet can then be sent as a group of adjacent PCM samples over a connection to the Internet. In other embodiments, information is sent to the Internet over a direct data pipe for transmitting ATM cells or Ethernet packets. A Vocoder signal processor can be inserted between the TSI memory, and the supplementary memory to convert PCM voice samples into vocoded voice samples for transmission over the Internet. A modem signal processor can be interposed between the TSI memory and the supplementary memory to convert between analog data (representing for example, shift key analog signals) and binary data for transmission within packets over the Internet. Advantageously, existing TSI units can be used to interface with both the telephone plant and the Internet.
摘要:
A large router for routing datagrams. The large router comprises a plurality of router slices, each of which receives switches and transmits datagrams. Each router slice has a routing memory for routing the packets. If a packet is received whose destination address is not known to the receiving packet slice, the packet slice broadcasts a request for routing information for that datagram to the other packet slices of the large router and routes the packet in accordance with the received responses. Groups of slices are interconnected by a time slot interchange (TSI) unit, and groups of TSIs are interconnected by a time multiplexed switch. The router can consist of more than one switch; the switches being interconnected by high speed data links. Advantageously, the router, though composed of small slices, acts as if it were a single large high capacity entity.
摘要:
A remote call redirection system located within a local access network which directs data traffic destined for the Internet to a channel connected directly to the Internet thereby reducing congestion within the local access network due to data traffic destined for the Internet.
摘要:
The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein with at least one carrier, excipient or diluent.
摘要:
The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
摘要:
The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
摘要:
The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficiency virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficiency virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.