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55 条记录 (耗时 0.04 秒)

    Compounds
    11.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号：US6001362A

    公开(公告)日：1999-12-14

    申请号：US093335

    申请日：1998-06-08

    申请人： Nicola Gail Wallis

    发明人： Nicola Gail Wallis

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/315 ,  C12N15/31 ,  A61K38/16 ,  A61K39/09 ,  C12N15/74

    CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00

    摘要： The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.

    摘要翻译： 本发明提供了响应调节剂多肽和编码响应调节剂多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用响应调节剂多肽筛选抗菌化合物的方法。

    Histidine kinase
    16.
    发明授权
    Histidine kinase 失效
    组氨酸激酶

    公开(公告)号：US06238885B1

    公开(公告)日：2001-05-29

    申请号：US09272414

    申请日：1999-03-19

    申请人： Nicola Gail Wallis

    发明人： Nicola Gail Wallis

    IPC分类号： C12P2106

    CPC分类号： C12N9/1205

    摘要： The invention provides histidine kinase polypeptides and polynucleotides encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.

    摘要翻译： 本发明提供了编码组氨酸激酶多肽的组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸，并通 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。

    Mur A-1 from Streptococcus pneumoniae
    17.
    发明授权
    Mur A-1 from Streptococcus pneumoniae 失效
    Mur A-1来自肺炎链球菌

    公开(公告)号：US06228627B1

    公开(公告)日：2001-05-08

    申请号：US09349851

    申请日：1999-07-08

    申请人： Nicola Gail Wallis

    发明人： Nicola Gail Wallis

    IPC分类号： C12N900

    CPC分类号： C12N9/1085 ,  A61K38/00 ,  A61K39/00

    摘要： Mur A-1 polypeptides and DNA (RNA) encoding such Mur A-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Mur A-1 for the treatment of infection, particularly bacterial infections. Antagonists against such Mur A-1 and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Mur A-1 nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding polypeptides having homology to Mur A-1 and for detecting such polypeptides in a host.

    摘要翻译： 公开了编码这种Mur A-1的MurA-1多肽和DNA（RNA），以及通过重组技术产生这种多肽的方法。 还公开了利用这种MurA-1来治疗感染，特别是细菌感染的方法。 还公开了抗这种Mur A-1的拮抗剂及其作为治疗感染的用途，特别是细菌感染。 还公开了用于检测与宿主中Mur A-1核酸序列和多肽存在相关的疾病的诊断测定法。 还公开了用于检测编码与Mur A-1具有同源性的多肽的多核苷酸和用于在宿主中检测此类多肽的诊断测定。

    Response regulator polynucleotides
    19.
    发明授权
    Response regulator polynucleotides 失效
    响应调节多核苷酸

    公开(公告)号：US5962259A

    公开(公告)日：1999-10-05

    申请号：US771783

    申请日：1996-12-20

    申请人： John Edward Hodgson ,  Nicola Gail Wallis

    发明人： John Edward Hodgson ,  Nicola Gail Wallis

    IPC分类号： G01N33/50 ,  A61K31/00 ,  A61K38/00 ,  A61K39/085 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  C07K14/31 ,  C07K16/12 ,  C12N1/21 ,  C12N15/00 ,  C12N15/31 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/566 ,  C12N5/10

    CPC分类号： C07K14/31 ,  A61K2039/51 ,  C07K2319/00

    摘要： Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.

    摘要翻译： 公开了新型的响应调节剂多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸和多肽治疗感染，特别是细菌感染的方法。 还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染，特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。 还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。