-
1.发明授权Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae 失效编码链球菌肺炎链球菌UDP-N-乙酰谷氨酰丙氨酸：D-谷氨酸连接酶（MurD）的多核苷酸的重组表达
公开(公告)号：US5929045A
公开(公告)日：1999-07-27
申请号：US934481
申请日：1997-09-19
IPC分类号： G01N33/50 , A61K31/00 , A61K38/00 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P27/00 , A61P27/16 , A61P31/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N1/21 , C12N9/00 , C12N15/00 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/46 , G01N33/15 , G01N33/566 , C12N5/10 , C12N15/31 , C12N15/63
摘要： The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurD多肽和编码MurD多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用MurD多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06350598B1
公开(公告)日：2002-02-26
申请号：US09290602
申请日：1999-04-13
IPC分类号： C12N900
摘要： The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了MurD多肽和编码MurD多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还提供了利用MurD多肽筛选抗菌化合物的方法。
-
3.发明授权Phospho-N-acetylmuramoyl-pentapeptide transferase of Streptococcus pneumoniae 失效肺炎链球菌的磷酸-N-乙酰基胞壁酰胺 - 五肽转移酶
公开(公告)号：US6156537A
公开(公告)日：2000-12-05
申请号：US61156
申请日：1998-04-16
申请人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
发明人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
IPC分类号： G01N33/15 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/395 , A61K48/00 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N15/09 , C12N15/31 , C12N15/54 , C12P21/02 , C12Q1/68 , C12N15/52 , C12N15/62 , C12N15/63
摘要： The invention provides mraY polypeptides and polynucleotides encoding mraY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mraY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了mraY多肽和编码mraY多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用mraY多肽筛选抗菌化合物的方法。
-
公开(公告)号：US06197300B1
公开(公告)日：2001-03-06
申请号：US09120426
申请日：1998-07-22
IPC分类号： A61K3900
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00
摘要： The invention provides ftsZ polypeptides and polynucleotides encoding ftsZ polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsZ polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ftsZ多肽和编码ftsZ多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ftsZ多肽筛选抗菌化合物的方法。
-
5.发明授权Automatically developing neuropsychiatric treatment plans based on neuroimage data 失效基于神经图像数据自动开发神经精神治疗计划公开(公告)号：US07996242B2
公开(公告)日：2011-08-09
申请号：US12169402
申请日：2008-07-08
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/325 , G06F19/3481 , G06Q50/22 , G16H10/60 , G16H50/20
摘要： A computer implemented method, apparatus, and computer program product for developing neuropsychiatric treatment plans. A treatment plan generator receives a set of diagnoses for a patient. The treatment plan generator automatically analyzes medical information in a set of electronic medical literature sources for potential therapies associated with treatment of each identified condition in the set of diagnoses. The treatment plan generator identifies the potential therapies associated with the treatment of each diagnosed condition. The treatment plan generator selects a set of recommended therapies from the potential therapies based on portions of the medical literature describing each therapy in the potential therapies and a medical history for the patient. The treatment plan generator generates a treatment plan. The treatment plan comprises the set of recommended therapies to treat each diagnosed condition in the set of diagnoses.
摘要翻译： 用于开发神经精神治疗计划的计算机实现的方法，装置和计算机程序产品。 治疗计划生成器接收患者的一组诊断。 治疗计划生成器自动分析一组电子医学文献来源中的医疗信息，用于与该组诊断中的每个识别的病症的治疗相关联的潜在疗法。 治疗计划生成器识别与每个诊断的病症的治疗相关的潜在疗法。 治疗计划生成者根据描述潜在疗法中的每种治疗的医学文献的部分以及患者的病史来选择潜在疗法中的一组推荐疗法。 治疗计划生成器产生治疗计划。 治疗计划包括一套推荐的治疗方法，用于治疗诊断中的每一个诊断病症。
-
6.发明申请公开(公告)号：US20090316969A1
公开(公告)日：2009-12-24
申请号：US12141322
申请日：2008-06-18
CPC分类号： G06F17/30244 , A61B5/055 , A61B5/16 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for determining the efficacy of neuropsychiatric therapy is provided. A neuroimage mapping manager automatically compares a first set of regions of interest in a first set of scans taken at a first time to a second set of regions of interest in a second set of scans generated at a second time and identifies a set of changes in the regions of interest occurring over time. The neuroimage mapping manager searches a set of electronic medical literature sources for medical literature relevant to the set of changes in the regions of interest and identifies portions of the relevant medical literature associated with the set of changes in the regions of interest. The neuroimage mapping manager generates results comprising the set of changes in the regions of interest and a set of links to the portions of the relevant medical literature.
摘要翻译： 提供了一种用于确定神经精神治疗疗效的计算机实现的方法，装置和计算机程序产品。 神经图像映射管理器将在第一时间拍摄的第一组扫描中的感兴趣区域的第一组区域自动地比较在第二时间生成的第二组扫描中的感兴趣区域的第二组，并且识别一组变化 感兴趣的地区随着时间的推移而发生。 神经图像映射管理器搜索一组电子医学文献来源，获取与感兴趣区域中的一组变化相关的医学文献，并且识别与感兴趣区域中的一组变化相关联的相关医学文献的部分。 神经图像映射管理器生成包含感兴趣区域中的一组变化的结果以及到相关医学文献部分的一组链接。
-
公开(公告)号：US20090240523A1
公开(公告)日：2009-09-24
申请号：US12054074
申请日：2008-03-24
IPC分类号： G06Q50/00
摘要： A computer implemented method for generating optimized pharmaceutical treatment plans for an individual. A set of known treatments to be used by the target individual over a future period of time is generated. An actual use of the treatments in the set of known treatments by the target individual during the future period of time is substantially certain. A set of probable treatments of the target individual is received. The actual use of the treatments in the set of probable treatments by the target individual during the future period of time is uncertain. An optimized pharmaceutical treatment plan for the target individual is generated. The optimized pharmaceutical treatment plan comprises medications and durable medical goods that are likely to be used by the target individual over the future period of time optimized over a set of dimensions associated with the set of known treatments and the set of probable treatments.
摘要翻译： 一种用于为个体生成优化的药物治疗计划的计算机实施方法。 产生一组目标个体在未来时间段内使用的已知治疗方法。 目标个体在未来时间段内对一组已知治疗的实际使用情况基本上是确定的。 收到一组目标个人的可能治疗。 目标个人在未来一段时间内在一组可能治疗中的实际使用是不确定的。 产生针对目标个体的优化药物治疗计划。 优化的药物治疗计划包括可能由目标个体在未来时间段内被使用的药物和耐久性医疗用品，其优化于与一组已知治疗和一组可能的治疗相关联的一组尺寸。
-
公开(公告)号：US08388529B2
公开(公告)日：2013-03-05
申请号：US12169339
申请日：2008-07-08
CPC分类号： G06T7/0012 , G06F19/00 , G06T2207/10016 , G06T2207/10072 , G06T2207/20104 , G06T2207/30016 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for generating neuropsychiatric diagnoses. Quantitative information describing diagnostic characteristics associated with a patient is generated based on an analysis of a set of patient scans. The quantitative information comprises a set of indictors associated with regions of interest in the set of scans for the patient. The set of indicators of potential neuropsychiatric conditions is compared with a set of diagnostic signatures. A diagnostic signature comprises a set of indicators of a known neuropsychiatric condition. Matching signatures are identified. A matching signature is a diagnostic signature that corresponds to at least one indicator in the set of indicators to form a set of signatures. A diagnosis associated with each signature in the set of signatures is identified to form a set of potential diagnoses. The set of potential diagnoses is presented with links to relevant portion of the medical literature.
摘要翻译： 一种用于产生神经精神科诊断的计算机实现的方法，装置和计算机程序产品。 基于对一组患者扫描的分析来生成描述与患者相关联的诊断特征的定量信息。 定量信息包括与患者的扫描集合中的感兴趣区域相关联的一组指示符。 将一组潜在神经精神病学指标与一组诊断标记进行比较。 诊断签名包括已知神经精神病状的一组指标。 识别匹配的签名。 匹配的签名是对应于该组指示符中的至少一个指示符以形成一组签名的诊断签名。 识别与该组签名中的每个签名相关联的诊断以形成一组潜在诊断。 该组潜在诊断呈现与医学文献相关部分的链接。
-
9.发明授权公开(公告)号：US08126228B2
公开(公告)日：2012-02-28
申请号：US12141322
申请日：2008-06-18
IPC分类号： G06K9/00
CPC分类号： G06F17/30244 , A61B5/055 , A61B5/16 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for determining the efficacy of neuropsychiatric therapy is provided. A neuroimage mapping manager automatically compares a first set of regions of interest in a first set of scans taken at a first time to a second set of regions of interest in a second set of scans generated at a second time and identifies a set of changes in the regions of interest occurring over time. The neuroimage mapping manager searches a set of electronic medical literature sources for medical literature relevant to the set of changes in the regions of interest and identifies portions of the relevant medical literature associated with the set of changes in the regions of interest. The neuroimage mapping manager generates results comprising the set of changes in the regions of interest and a set of links to the portions of the relevant medical literature.
摘要翻译： 提供了一种用于确定神经精神治疗疗效的计算机实现的方法，装置和计算机程序产品。 神经图像映射管理器将在第一时间拍摄的第一组扫描中的感兴趣区域的第一组区域自动地比较在第二时间生成的第二组扫描中的感兴趣区域的第二组，并且识别一组变化 感兴趣的地区随着时间的推移而发生。 神经图像映射管理器搜索一组电子医学文献来源，获取与感兴趣区域中的一组变化相关的医学文献，并且识别与感兴趣区域中的一组变化相关联的相关医学文献的部分。 神经图像映射管理器生成包含感兴趣区域中的一组变化的结果以及到相关医学文献部分的一组链接。
-
10.发明授权公开(公告)号：US08199982B2
公开(公告)日：2012-06-12
申请号：US12141316
申请日：2008-06-18
IPC分类号： G06K9/00
CPC分类号： G06F19/345 , A61B5/055 , A61B6/037 , A61B6/501 , G06F19/00 , G06F19/321 , G06F19/324 , G06T7/0012 , G06T2207/20104 , G06T2207/30016 , G16H50/20 , G16H50/70
摘要： A computer implemented method, apparatus, and computer program product for analyzing neurological images. A set of brain scans for a patient is compared to a set of baseline control scans to automatically identify regions of interest in the set of patient scans. A region of interest is an area in a scan that shows an indication of a potential abnormality. A set of electronic medical literature sources is searched for medical literature relevant to the regions of interest in the set of patient scans. The relevant medical literature is correlated to the medical literature describing the regions of interest in the set of patient scans to the regions of interest in the set of patient scans. A result is generated. The result comprises the regions of interest and a set of links to the correlated portions of the relevant medical literature are outputted.
摘要翻译： 一种用于分析神经图像的计算机实现的方法，装置和计算机程序产品。 将一组患者的脑扫描与一组基线控制扫描进行比较，以自动识别该组患者扫描中的感兴趣区域。 感兴趣区域是显示潜在异常的指示的扫描区域。 一组电子医学文献来源搜索与该组患者扫描相关的感兴趣区域的医学文献。 相关的医学文献与将病人扫描的病人扫描中的感兴趣区域描述在该组病人扫描中的感兴趣区域的医学文献相关。 产生结果。 输出结果包括感兴趣区域和与相关医学文献的相关部分的一组链接。
-
-
-
-
-
-
-
-
-
搜索结果
20 条记录 (耗时 0.02 秒)