Compounds
    1.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号:US06498234B1

    公开(公告)日:2002-12-24

    申请号:US09524643

    申请日:2000-03-14

    IPC分类号: C07C100

    摘要: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。

    MurF
    3.
    发明授权
    MurF 失效
    Murf

    公开(公告)号:US06287807B1

    公开(公告)日:2001-09-11

    申请号:US09144918

    申请日:1998-09-01

    IPC分类号: C12P2106

    CPC分类号: C12N9/93

    摘要: The invention provides MurF polypeptides and polynucleotides encoding MurF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurF polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供了MurF多肽和编码MurF多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用MurF多肽筛选抗菌化合物的方法。

    Compounds
    4.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号:US06268172B1

    公开(公告)日:2001-07-31

    申请号:US08879941

    申请日:1997-06-20

    IPC分类号: C12P2106

    摘要: The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。

    Compounds
    6.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号:US06224869B1

    公开(公告)日:2001-05-01

    申请号:US09321276

    申请日:1999-05-27

    IPC分类号: A61K3902

    CPC分类号: C07K14/3156 A61K39/00

    摘要: The invention provides response regulator polypeptides and DNA (RNA) encoding response regulator polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing response regulator polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供了响应调节多肽和编码响应调节多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用响应调节剂多肽筛选抗菌化合物的方法。

    DNA encoding tests polypeptides
    7.
    发明授权
    DNA encoding tests polypeptides 失效
    DNA编码测试多肽

    公开(公告)号:US6001600A

    公开(公告)日:1999-12-14

    申请号:US771098

    申请日:1996-12-20

    CPC分类号: C07K14/31 A61K38/00

    摘要: Novel response regulator polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides and polypeptides for the treatment of infection, particularly bacterial infections. Antagonists against such the polypeptides of the invention and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence the nucleic acid sequences and the polypeptides of the invention in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding response regulators and for detecting the polypeptide in a host.

    摘要翻译: 公开了新型的响应调节剂多肽和编码这种多肽的DNA(RNA)以及通过重组技术产生此类多肽的方法。 还公开了利用这种多核苷酸和多肽治疗感染,特别是细菌感染的方法。 还公开了抗这些本发明多肽的拮抗剂及其作为治疗感染,特别是细菌感染的治疗剂的用途。 还公开了用于检测与宿主中本发明的核酸序列和多肽相关的疾病的诊断测定法。 还公开了用于检测编码响应调节剂的多核苷酸和用于在宿主中检测多肽的诊断测定。

    Compounds
    8.
    发明授权
    Compounds 失效
    化合物

    公开(公告)号:US6001362A

    公开(公告)日:1999-12-14

    申请号:US093335

    申请日:1998-06-08

    摘要: The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.

    摘要翻译: 本发明提供了响应调节剂多肽和编码响应调节剂多肽的DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用响应调节剂多肽筛选抗菌化合物的方法。