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公开(公告)号：US20060194714A1
公开(公告)日：2006-08-31
申请号：US11414762
申请日：2006-04-28
申请人： John Finn , Michael Morytko , Ian Parr , Michael Jung
发明人： John Finn , Michael Morytko , Ian Parr , Michael Jung
IPC分类号： A61K38/12
摘要： The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
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公开(公告)号：US06333344B1
公开(公告)日：2001-12-25
申请号：US09566112
申请日：2000-05-05
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
IPC分类号： A61K314184
CPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34
摘要： Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.
摘要翻译： 转移核糖核酸（tRNA）合成酶抑制剂，其盐和药学上可接受的组合物，其通式为：其中Ar为芳基和杂芳基; L是-C（O）N（Q）CH 2 - 或-CR 10 R 11 OCR 12 R 13 - ; Q是氢， - （CH 2）m CO 2 H和 - （CH 2）m CO 2 CH 3，m是1,2,3和4; R1，R2，R9，R10，R11，R12和R13是氢或低级烷基; 其中Het是杂环部分，所述抑制剂适合用作抗微生物剂。
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公开(公告)号：US06579894B2
公开(公告)日：2003-06-17
申请号：US10173054
申请日：2002-06-17
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
IPC分类号： A61K314184
CPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34
摘要： Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.
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公开(公告)号：US06417217B1
公开(公告)日：2002-07-09
申请号：US09935033
申请日：2001-08-22
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Siya Ram , Dennis Keith
IPC分类号： A61K314184
CPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34
摘要： Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.
摘要翻译： 转移核糖核酸（tRNA）合成酶抑制剂，其盐和药学上可接受的组合物，其通式为：其中Ar为芳基和杂芳基; L是-C（O）N（Q）CH 2 - 或-CR 10 R 11 OCR 12 R 13 - ; Q是氢， - （CH 2）m CO 2 H和 - （CH 2）m CO 2 CH 3，m是1,2,3和4; R1，R2，R9，R10，R11，R12和R13是氢或低级烷基; 其中Het是杂环部分，所述抑制剂适合用作抗微生物剂。
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15.发明授权Lipopeptide stereoisomers, methods for preparing same, and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US07262268B2
公开(公告)日：2007-08-28
申请号：US10213218
申请日：2002-08-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： A61K38/12
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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16.发明申请Lipopeptide stereoisomers, methods for preparing same and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US20060223983A1
公开(公告)日：2006-10-05
申请号：US11448066
申请日：2006-06-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： C07K7/60
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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17.发明授权Lipopeptide stereoisomers, methods for preparing same and useful intermediates 失效脂肽立体异构体，其制备方法和有用的中间体公开(公告)号：US07335726B2
公开(公告)日：2008-02-26
申请号：US11448066
申请日：2006-06-06
申请人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
发明人： Michael Morytko , Yanzhi Zhang , Michael Jung , John Finn
IPC分类号： C07K7/60
摘要： The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.
摘要翻译： 本发明提供达托霉素立体异构体化合物，制备达托霉素和达托霉素立体异构体化合物的方法和中间体，以及这些化合物的药物组合物和使用这些组合物作为抗菌剂的方法。
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公开(公告)号：US20080076924A1
公开(公告)日：2008-03-27
申请号：US11824441
申请日：2007-06-29
申请人： Patrick Betschmann , William Carroll , Anna Ericsson , Shannon Fix-Stenzel , Michael Friedman , Gavin Hirst , Nathan Josephsohn , Biqin Li , Arturo Perez-Medrano , Michael Morytko , Paul Rafferty , Haipeng Chen
发明人： Patrick Betschmann , William Carroll , Anna Ericsson , Shannon Fix-Stenzel , Michael Friedman , Gavin Hirst , Nathan Josephsohn , Biqin Li , Arturo Perez-Medrano , Michael Morytko , Paul Rafferty , Haipeng Chen
IPC分类号： C07D471/04 , C07D401/00
CPC分类号： C07D241/04 , C07D241/36 , C07D295/215 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其代谢物，其异构体，其对映体或式（I）的前药，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：US20070099925A1
公开(公告)日：2007-05-03
申请号：US11514626
申请日：2006-09-01
申请人： David Calderwood , Kristine Frank , Patrick Betschmann , Gavin Hirst , Eric Brieinlinger , Michael Morytko , Richard Dixon
发明人： David Calderwood , Kristine Frank , Patrick Betschmann , Gavin Hirst , Eric Brieinlinger , Michael Morytko , Richard Dixon
IPC分类号： A61K31/519 , A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译： 本发明涉及式（I）的新型咪唑并吡嗪和咪唑并嘧啶化合物，其中变量如本文所定义。 式（I）化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性病症和病症，例如癌症。
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