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公开(公告)号：US20080076924A1
公开(公告)日：2008-03-27
申请号：US11824441
申请日：2007-06-29
申请人： Patrick Betschmann , William Carroll , Anna Ericsson , Shannon Fix-Stenzel , Michael Friedman , Gavin Hirst , Nathan Josephsohn , Biqin Li , Arturo Perez-Medrano , Michael Morytko , Paul Rafferty , Haipeng Chen
发明人： Patrick Betschmann , William Carroll , Anna Ericsson , Shannon Fix-Stenzel , Michael Friedman , Gavin Hirst , Nathan Josephsohn , Biqin Li , Arturo Perez-Medrano , Michael Morytko , Paul Rafferty , Haipeng Chen
IPC分类号： C07D471/04 , C07D401/00
CPC分类号： C07D241/04 , C07D241/36 , C07D295/215 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译： 式（I）的新型化合物或其药学上可接受的盐，其代谢物，其异构体，其对映体或式（I）的前药，其中取代基如本文所定义，其可用作治疗剂。
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公开(公告)号：US20060052374A1
公开(公告)日：2006-03-09
申请号：US11221333
申请日：2005-09-07
申请人： William Carroll , Arturo Perez-Medrano , Alan Florjancic , Derek Nelson , Sridhar Peddi , Tongmei Li , Eric Bunnelle , Gavin Hirst , Biquin Li
发明人： William Carroll , Arturo Perez-Medrano , Alan Florjancic , Derek Nelson , Sridhar Peddi , Tongmei Li , Eric Bunnelle , Gavin Hirst , Biquin Li
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/415 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 具有式（I）或式（II）的化合物
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公开(公告)号：US20070049584A1
公开(公告)日：2007-03-01
申请号：US11120718
申请日：2005-04-29
申请人： William Carroll , Arturo Perez-Medrano , Alan Florjancic , Derek Nelson , Sridhar Peddi , Tongmei Li , Eric Bunnelle , Gavin Hirst , Biquin Li
发明人： William Carroll , Arturo Perez-Medrano , Alan Florjancic , Derek Nelson , Sridhar Peddi , Tongmei Li , Eric Bunnelle , Gavin Hirst , Biquin Li
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/41 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X 7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1， R 2，R 3，R 4，R 4和R 5如本文所定义。 描述。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US20120329772A1
公开(公告)日：2012-12-27
申请号：US13544387
申请日：2012-07-09
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： C07D257/06 , C07D413/12 , A61K31/5377 , C07D401/12 , A61K31/4439 , A61K31/4709 , C07D409/12 , C07D403/12 , A61K31/497 , A61K31/4155 , A61K31/435 , C07D405/12 , A61K31/496 , C07D491/048 , A61K31/4355 , C07D417/12 , A61K31/427 , A61K31/506 , C07D401/14 , A61K31/444 , C07D413/14 , A61K31/551 , A61K31/55 , A61K31/553 , C07D487/04 , A61P29/00 , A61P25/28 , A61P25/24 , A61P25/00 , A61K31/41
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US20080171733A1
公开(公告)日：2008-07-17
申请号：US12051565
申请日：2008-03-19
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/397 , A61K31/41 , A61K31/5377 , A61K31/4427 , A61K31/47 , A61K31/497 , A61P29/00 , A61P25/00 , A61K31/5513 , A61K31/496 , A61K31/445 , A61K31/426 , A61K31/506
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X 7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1， R 2，R 3，R 4，R 4和R 5如本文所定义。 描述。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US08546374B2
公开(公告)日：2013-10-01
申请号：US13544387
申请日：2012-07-09
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biquin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biquin C. Li
IPC分类号： C07D257/06 , C07D413/12 , C07D401/12 , C07D409/12 , C07D403/12 , C07D405/12 , C07D491/048 , C07D417/12 , C07D401/14 , C07D413/14 , C07D487/04 , A61K31/41 , A61K31/5377 , A61K31/4439 , A61K31/4709 , A61K31/497 , A61K31/435 , A61K31/4155 , A61K31/496 , A61K31/4355 , A61K31/427 , A61K31/506 , A61K31/444 , A61K31/551 , A61K31/55 , A61K31/553 , A61P29/00 , A61P25/28 , A61P25/24 , A61P25/00
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US07704997B1
公开(公告)日：2010-04-27
申请号：US11221333
申请日：2005-09-07
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/551 , A61K31/496 , A61K31/5377 , A61K31/4545 , A61K31/444 , A61K31/4439 , A61K31/4709 , C07D243/08 , C07D413/14 , C07D401/14 , C07D215/12 , C07D213/02 , C07D401/12
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US08217067B2
公开(公告)日：2012-07-10
申请号：US11120718
申请日：2005-04-29
申请人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
发明人： William A. Carroll , Arturo Perez-Medrano , Alan S. Florjancic , Derek W. Nelson , Sridhar Peddi , Tongmei Li , Eric M. Bunnelle , Gavin Hirst , Biqin C. Li
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D487/04 , C07D257/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , C07D491/04 , C07D491/048 , C07D491/08
摘要： A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.
摘要翻译： 公开了具有式（I）或式（II）的化合物作为P2X7拮抗剂，其中A，B，C，Y，Y，Z，m，v，R 1，R 2，R 3，R 4和R 5如 在说明中。 还公开了用于治疗由P2X7调节的疾病或病症的方法和组合物。
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公开(公告)号：US20070232686A1
公开(公告)日：2007-10-04
申请号：US11750633
申请日：2007-05-18
IPC分类号： A61K31/16 , A61K31/155 , A61K31/17 , A61K31/275 , C07C255/00 , C07C261/04 , C07C277/02 , C07C279/28 , C07D309/00
CPC分类号： C07D295/135 , C07C261/04 , C07D213/58 , C07D215/12 , C07D317/60 , C07D319/18
摘要： Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.
摘要翻译： 式（I）和（II）的新型氰酰脒化合物及其衍生物，其中R 1 -R 12如本说明书中所定义，作为P2X的拮抗剂， 7受体。 这些化合物特别可用于治疗疼痛，炎症和神经变性状态。
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10.发明申请公开(公告)号：US20080064699A1
公开(公告)日：2008-03-13
申请号：US11755884
申请日：2007-05-31
申请人： Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
发明人： Alan Florjancic , Michael Dart , Keith Ryther , Arturo Perez-Medrano , William Carroll , Meena Patel , Karin Tietje , Tongmei Li , Teodozyj Kolasa , Megan Gallagher , Sridhar Peddi , Jennifer Frost , Derek Nelson
IPC分类号： C07D277/38 , A61K31/426 , A61K31/428 , A61K31/4427 , C07D417/02 , C07D277/62 , A61K31/5377 , A61P25/00
CPC分类号： C07D277/46 , A61K31/429 , C07D277/48 , C07D277/82 , C07D417/04 , C07D417/06 , C07D417/12 , C07D493/08 , C07D513/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L2, are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，前体药物，前药盐或其组合，其中R 1，R 2，R 2， 在本说明书中定义了含有这些化合物的组合物，以及使用这些化合物治疗病症和病症的方法，其中，R 3，R 4，R 2和L 2 和组合物。
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